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ADGRF3 adhesion G protein-coupled receptor F3 [ Homo sapiens (human) ]

Gene ID: 165082, updated on 26-Oct-2022

Summary

Official Symbol
ADGRF3provided by HGNC
Official Full Name
adhesion G protein-coupled receptor F3provided by HGNC
Primary source
HGNC:HGNC:18989
See related
Ensembl:ENSG00000173567 AllianceGenome:HGNC:18989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR23; GPR113
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ADGRF3 in Genome Data Viewer
Location:
2p23.3
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (26308173..26346789, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (26343551..26385469, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (26531041..26569657, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene GRB2 associated regulator of MAPK1 subtype 2 Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha Neighboring gene hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta Neighboring gene uncharacterized LOC105374334 Neighboring gene selenoprotein I Neighboring gene dynein regulatory complex subunit 1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:26685720-26686919 Neighboring gene otoferlin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16767

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adhesion G-protein coupled receptor F3
Names
G protein-coupled receptor 113
G protein-coupled receptor PGR23
probable G-protein coupled receptor 113
seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145168.1NP_001138640.1  adhesion G-protein coupled receptor F3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001138640.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC010896, AY140955
    Consensus CDS
    CCDS46239.1
    UniProtKB/Swiss-Prot
    Q8IZF5, Q8TDT3
    Related
    ENSP00000307831.1, ENST00000311519.5
    Conserved Domains (3) summary
    pfam01825
    Location:713758
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:431477
    HRM; Hormone receptor domain
    cl21561
    Location:7701016
    7tm_4; Olfactory receptor
  2. NM_001145169.1NP_001138641.1  adhesion G-protein coupled receptor F3 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has alternate 5' and 3' sequences, as compared to variant 1. The resulting isoform (2) lacks an internal segment in the N-terminal region and has a shorter and different C-terminus, as compared to isoform 1.
    Source sequence(s)
    AA459569, AK293887, AY140955, BC043211
    Consensus CDS
    CCDS46238.1
    UniProtKB/Swiss-Prot
    Q8IZF5
    Related
    ENSP00000388537.2, ENST00000421160.6
    Conserved Domains (3) summary
    cd15253
    Location:698968
    7tmB2_GPR113; orphan adhesion receptor GPR113, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:362408
    HRM; Hormone receptor domain
    pfam01825
    Location:644689
    GPS; GPCR proteolysis site, GPS, motif
  3. NM_001321971.2NP_001308900.1  adhesion G-protein coupled receptor F3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC010896, AK293887, AY358172, BC043211
    Consensus CDS
    CCDS92721.1
    UniProtKB/Swiss-Prot
    Q8IZF5
    UniProtKB/TrEMBL
    A0A494C083
    Related
    ENSP00000498434.1, ENST00000651242.2
    Conserved Domains (3) summary
    pfam01825
    Location:645690
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:363409
    HRM; Hormone receptor domain
    cl21561
    Location:702948
    7tm_4; Olfactory receptor
  4. NM_001321975.2NP_001308904.1  adhesion G-protein coupled receptor F3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC010896, AY140955, BC043211, HY209981
    UniProtKB/Swiss-Prot
    Q8IZF5
    Related
    ENST00000459892.5
    Conserved Domains (3) summary
    cd15253
    Location:370640
    7tmB2_GPR113; orphan adhesion receptor GPR113, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:316361
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:3480
    HRM; Hormone receptor domain
  5. NM_001393343.1NP_001380272.1  adhesion G-protein coupled receptor F3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC010896
    Conserved Domains (3) summary
    cd15253
    Location:370640
    7tmB2_GPR113; orphan adhesion receptor GPR113, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam01825
    Location:316361
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:3480
    HRM; Hormone receptor domain
  6. NM_153835.4NP_722577.2  adhesion G-protein coupled receptor F3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has alternate 5' and 3' sequences and lacks two internal in-frame coding exons, as compared to variant 1. The resulting isoform (3) has shorter and different N- and C-termini and lack an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC010896, AY358172, BC043211
    Consensus CDS
    CCDS33159.2
    UniProtKB/Swiss-Prot
    Q8IZF5
    Related
    ENSP00000327396.6, ENST00000333478.10
    Conserved Domains (3) summary
    pfam01825
    Location:514559
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:232278
    HRM; Hormone receptor domain
    cl21561
    Location:571817
    7tm_4; Olfactory receptor

RNA

  1. NR_135916.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AY140955, AY358172, BC043211
    Related
    ENST00000435303.1
  2. NR_171656.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010896
  3. NR_171657.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010896

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    26308173..26346789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443563.1XP_047299519.1  adhesion G-protein coupled receptor F3 isoform X2

  2. XM_011532621.4XP_011530923.1  adhesion G-protein coupled receptor F3 isoform X1

    Conserved Domains (3) summary
    pfam01825
    Location:654699
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:372418
    HRM; Hormone receptor domain
    cl21561
    Location:711957
    7tm_4; Olfactory receptor
  3. XM_047443565.1XP_047299521.1  adhesion G-protein coupled receptor F3 isoform X5

  4. XM_011532622.3XP_011530924.1  adhesion G-protein coupled receptor F3 isoform X3

    Conserved Domains (3) summary
    pfam01825
    Location:644689
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:362408
    HRM; Hormone receptor domain
    cl21561
    Location:701947
    7tm_4; Olfactory receptor
  5. XM_047443564.1XP_047299520.1  adhesion G-protein coupled receptor F3 isoform X4

  6. XM_011532623.3XP_011530925.1  adhesion G-protein coupled receptor F3 isoform X4

    See identical proteins and their annotated locations for XP_011530925.1

    Conserved Domains (3) summary
    pfam01825
    Location:638683
    GPS; GPCR proteolysis site, GPS, motif
    pfam02793
    Location:356402
    HRM; Hormone receptor domain
    cl21561
    Location:695941
    7tm_4; Olfactory receptor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    26343551..26385469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)