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Kcnc1 potassium voltage gated channel, Shaw-related subfamily, member 1 [ Mus musculus (house mouse) ]

Gene ID: 16502, updated on 14-May-2024

Summary

Official Symbol
Kcnc1provided by MGI
Official Full Name
potassium voltage gated channel, Shaw-related subfamily, member 1provided by MGI
Primary source
MGI:MGI:96667
See related
Ensembl:ENSMUSG00000058975 AllianceGenome:MGI:96667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KV4; NGK2; Shaw; Kv3.1; Kcr2-1; KShIIIB; C230009H10Rik
Summary
Enables kinesin binding activity and transmembrane transporter binding activity. Predicted to be involved in positive regulation of voltage-gated potassium channel activity; potassium ion transmembrane transport; and protein tetramerization. Predicted to act upstream of or within potassium ion transport. Located in axolemma; dendrite membrane; and neuronal cell body membrane. Is expressed in brain and hindlimb muscle. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 7. Orthologous to human KCNC1 (potassium voltage-gated channel subfamily C member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 44.0), frontal lobe adult (RPKM 12.4) and 4 other tissues See more
Orthologs
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Genomic context

See Kcnc1 in Genome Data Viewer
Location:
7 B3; 7 30.1 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46045643..46088130)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46396219..46438706)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9691 Neighboring gene predicted gene, 45923 Neighboring gene myogenic differentiation 1 Neighboring gene STARR-positive B cell enhancer ABC_E4927 Neighboring gene secretion regulating guanine nucleotide exchange factor Neighboring gene predicted gene, 22969 Neighboring gene STARR-seq mESC enhancer starr_18863 Neighboring gene STARR-seq mESC enhancer starr_18865 Neighboring gene STARR-seq mESC enhancer starr_18866 Neighboring gene STARR-seq mESC enhancer starr_18867 Neighboring gene tryptophan hydroxylase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • C230009H10Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables kinesin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of monoatomic ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein tetramerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of monoatomic ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axolemma IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in calyx of Held ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal cell body membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily C member 1
Names
voltage-gated potassium channel subunit Kv3.1
voltage-gated potassium channel subunit Kv4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112739.2NP_001106210.1  potassium voltage-gated channel subfamily C member 1 isoform 1

    See identical proteins and their annotated locations for NP_001106210.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC020786, AC090652, AK162964, BB750064, CJ130517
    Consensus CDS
    CCDS52252.1
    UniProtKB/TrEMBL
    Q3TR92
    Related
    ENSMUSP00000124938.2, ENSMUST00000160433.3
    Conserved Domains (2) summary
    cd18414
    Location:6122
    BTB_KCNC1_3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3
    pfam00520
    Location:189447
    Ion_trans; Ion transport protein
  2. NM_008421.3NP_032447.1  potassium voltage-gated channel subfamily C member 1 isoform 2

    See identical proteins and their annotated locations for NP_032447.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two exons and its 3' exon extends past a splice site used in variant 1, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC020786, AC090652
    Consensus CDS
    CCDS21278.1
    UniProtKB/Swiss-Prot
    E9PVV3, P15388
    UniProtKB/TrEMBL
    Q3UHB6
    Related
    ENSMUSP00000025202.7, ENSMUST00000025202.8
    Conserved Domains (2) summary
    cd18414
    Location:6122
    BTB_KCNC1_3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3
    pfam00520
    Location:189447
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    46045643..46088130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540646.2XP_006540709.1  potassium voltage-gated channel subfamily C member 1 isoform X1

    Conserved Domains (2) summary
    cd18414
    Location:6122
    BTB_KCNC1_3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3
    pfam00520
    Location:189447
    Ion_trans; Ion transport protein
  2. XM_006540647.2XP_006540710.1  potassium voltage-gated channel subfamily C member 1 isoform X2

    See identical proteins and their annotated locations for XP_006540710.1

    UniProtKB/TrEMBL
    Q3TR92
    Conserved Domains (2) summary
    cd18414
    Location:6122
    BTB_KCNC1_3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3
    pfam00520
    Location:189447
    Ion_trans; Ion transport protein
  3. XM_006540648.2XP_006540711.1  potassium voltage-gated channel subfamily C member 1 isoform X3

    Conserved Domains (2) summary
    cd18414
    Location:6122
    BTB_KCNC1_3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3
    pfam00520
    Location:189447
    Ion_trans; Ion transport protein