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DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit [ Homo sapiens (human) ]

Gene ID: 1650, updated on 5-Jul-2020

Summary

Official Symbol
DDOSTprovided by HGNC
Official Full Name
dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunitprovided by HGNC
Primary source
HGNC:HGNC:2728
See related
Ensembl:ENSG00000244038 MIM:602202
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OST; WBP1; AGER1; CDG1R; GATD6; OST48; OKSWcl45
Summary
This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 112.6), placenta (RPKM 100.3) and 25 other tissues See more
Orthologs

Genomic context

See DDOST in Genome Data Viewer
Location:
1p36.12
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (20651777..20661369, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20978260..20988037, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cytidine deaminase Neighboring gene microRNA 6084 Neighboring gene PTEN induced kinase 1 Neighboring gene PINK1 antisense RNA Neighboring gene kinesin family member 17 Neighboring gene SH2 domain containing 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of dolichyl-diphosphooligosaccharide--protein glycosyltransferase (DDOST; OST48) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify dolichyl-diphosphooligosaccharide--protein glycosyltransferase, HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify dolichyl-diphosphooligosaccharide--protein glycosyltransferase, HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify dolichyl-diphosphooligosaccharide--protein glycosyltransferase, HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify dolichyl-diphosphooligosaccharide--protein glycosyltransferase, HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2191, KIAA0115

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell activation IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
protein N-linked glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein N-linked glycosylation via asparagine IC
Inferred by Curator
more info
PubMed 
protein N-linked glycosylation via asparagine TAS
Traceable Author Statement
more info
 
protein glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cytokine IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
azurophil granule membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oligosaccharyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
oligosaccharyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit
Names
advanced glycation end-product receptor 1
advanced glycation endproduct receptor 1
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
dolichyl-diphosphooligosaccharide-protein glycotransferase
oligosaccharyl transferase 48 kDa subunit
oligosaccharyltransferase 48 kDa subunit
oligosaccharyltransferase subunit 48
NP_005207.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032064.1 RefSeqGene

    Range
    5001..14778
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005216.5NP_005207.3  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor

    Status: REVIEWED

    Source sequence(s)
    AB062391, AL391357, BC002594
    Consensus CDS
    CCDS212.1
    Related
    ENSP00000473655.1, ENST00000602624.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    20651777..20661369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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