U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kcnab3 potassium voltage-gated channel, shaker-related subfamily, beta member 3 [ Mus musculus (house mouse) ]

Gene ID: 16499, updated on 18-Sep-2024

Summary

Official Symbol
Kcnab3provided by MGI
Official Full Name
potassium voltage-gated channel, shaker-related subfamily, beta member 3provided by MGI
Primary source
MGI:MGI:1336208
See related
Ensembl:ENSMUSG00000018470 AllianceGenome:MGI:1336208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kcnab4; mKv(beta)4; C330022D06Rik
Summary
Predicted to enable aldo-keto reductase (NADP) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Predicted to be involved in regulation of potassium ion transmembrane transport. Predicted to act upstream of or within ion transport and regulation of ion transmembrane transport. Predicted to be located in cytoplasm. Predicted to be integral component of membrane. Predicted to be part of voltage-gated potassium channel complex. Is expressed in central nervous system; eye; heart; intestine; and male reproductive gland or organ. Orthologous to human KCNAB3 (potassium voltage-gated channel subfamily A regulatory beta subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 22.4), frontal lobe adult (RPKM 21.7) and 8 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Kcnab3 in Genome Data Viewer
Location:
11 B3; 11 42.51 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69217084..69223867)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69326258..69333041)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene centrobin, centrosomal BRCA2 interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E1829 Neighboring gene trafficking protein particle complex 1 Neighboring gene ring finger protein 227 Neighboring gene chromodomain helicase DNA binding protein 3 Neighboring gene predicted gene, 22442

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aldo-keto reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
voltage-gated potassium channel subunit beta-3
Names
K(+) channel subunit beta-3
kv-beta-3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010599.4NP_034729.3  voltage-gated potassium channel subunit beta-3

    See identical proteins and their annotated locations for NP_034729.3

    Status: VALIDATED

    Source sequence(s)
    AK049316, AK083134
    Consensus CDS
    CCDS24890.1
    UniProtKB/TrEMBL
    Q8BQX9, Q8C439, Q8C7S9, Q8VD73
    Related
    ENSMUSP00000018614.3, ENSMUST00000018614.3
    Conserved Domains (2) summary
    cd06660
    Location:80395
    Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...
    TIGR01293
    Location:80396
    Kv_beta; voltage-dependent potassium channel beta subunit, animal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    69217084..69223867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)