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Kcna6 potassium voltage-gated channel, shaker-related, subfamily, member 6 [ Mus musculus (house mouse) ]

Gene ID: 16494, updated on 18-Sep-2024

Summary

Official Symbol
Kcna6provided by MGI
Official Full Name
potassium voltage-gated channel, shaker-related, subfamily, member 6provided by MGI
Primary source
MGI:MGI:96663
See related
Ensembl:ENSMUSG00000038077 AllianceGenome:MGI:96663
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kv1.6; MK1.6
Summary
Predicted to enable delayed rectifier potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within ion transport and regulation of ion transmembrane transport. Located in axon terminus. Is expressed in several structures, including central nervous system; embryo mesenchyme; hindlimb muscle; neural retina; and trigeminal nerve. Orthologous to human KCNA6 (potassium voltage-gated channel subfamily A member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 9.9), cortex adult (RPKM 8.5) and 7 other tissues See more
Orthologs
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Genomic context

See Kcna6 in Genome Data Viewer
Location:
6 F3; 6 61.72 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (126685292..126717610, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (126708328..126740834, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33496 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 1 Neighboring gene predicted gene, 33581 Neighboring gene predicted gene, 20190 Neighboring gene STARR-seq mESC enhancer starr_17397 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables delayed rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily A member 6
Names
voltage-gated potassium channel subunit Kv1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410072.1NP_001397001.1  potassium voltage-gated channel subfamily A member 6

    Status: VALIDATED

    Source sequence(s)
    AC079438, AC124756
    UniProtKB/Swiss-Prot
    Q61923
  2. NM_001410074.1NP_001397003.1  potassium voltage-gated channel subfamily A member 6

    Status: VALIDATED

    Source sequence(s)
    AC079438, AC124756
    UniProtKB/Swiss-Prot
    Q61923
    Related
    ENSMUSP00000107861.2, ENSMUST00000112242.2
  3. NM_001410075.1NP_001397004.1  potassium voltage-gated channel subfamily A member 6

    Status: VALIDATED

    Source sequence(s)
    AC079438, AC124756
    UniProtKB/Swiss-Prot
    Q61923
  4. NM_013568.7NP_038596.1  potassium voltage-gated channel subfamily A member 6

    See identical proteins and their annotated locations for NP_038596.1

    Status: VALIDATED

    Source sequence(s)
    AC079438, AC124756
    Consensus CDS
    CCDS20556.1
    UniProtKB/Swiss-Prot
    Q61923
    Related
    ENSMUSP00000036872.6, ENSMUST00000040751.6
    Conserved Domains (2) summary
    cd18407
    Location:41170
    BTB_POZ_KCNA6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 6 (KCNA6)
    pfam00520
    Location:258468
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    126685292..126717610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)