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Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 [ Mus musculus (house mouse) ]

Gene ID: 16491, updated on 9-Mar-2023

Summary

Official Symbol
Kcna3provided by MGI
Official Full Name
potassium voltage-gated channel, shaker-related subfamily, member 3provided by MGI
Primary source
MGI:MGI:96660
See related
Ensembl:ENSMUSG00000047959 AllianceGenome:MGI:96660
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mk-3; Kv1.3; Kca1-3
Summary
Predicted to enable delayed rectifier potassium channel activity and outward rectifier potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within potassium ion transport and regulation of ion transmembrane transport. Located in axon. Is expressed in brain; heart; olfactory cortex mantle layer; and telencephalon. Orthologous to human KCNA3 (potassium voltage-gated channel subfamily A member 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Kcna3 in Genome Data Viewer
Location:
3 F2.3; 3 46.59 cM
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (106943478..106945445)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107036162..107038129)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 18162 Neighboring gene predicted gene, 27008 Neighboring gene expressed sequence AI504432 Neighboring gene predicted gene, 38712 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables outward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in calyx of Held ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
potassium voltage-gated channel subfamily A member 3
Names
MK3
Voltage-gated potassium channel protein Kv1.3 (RGK5) (RCK3) (KV3)
voltage-gated potassium channel subunit Kv1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008418.3NP_032444.2  potassium voltage-gated channel subfamily A member 3

    See identical proteins and their annotated locations for NP_032444.2

    Status: VALIDATED

    Source sequence(s)
    AC121825
    Consensus CDS
    CCDS17730.1
    UniProtKB/Swiss-Prot
    A3KMM2, P16390
    UniProtKB/TrEMBL
    A0A8C6IPC6
    Related
    ENSMUSP00000050680.4, ENSMUST00000052718.5
    Conserved Domains (4) summary
    smart00225
    Location:59153
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:243443
    Ion_trans; Ion transport protein
    pfam02214
    Location:59150
    BTB_2; BTB/POZ domain
    pfam07885
    Location:357434
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    106943478..106945445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)