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Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 [ Mus musculus (house mouse) ]

Gene ID: 16490, updated on 8-Dec-2022

Summary

Official Symbol
Kcna2provided by MGI
Official Full Name
potassium voltage-gated channel, shaker-related subfamily, member 2provided by MGI
Primary source
MGI:MGI:96659
See related
Ensembl:ENSMUSG00000040724 AllianceGenome:MGI:96659
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mk-2; Kv1.2; Akr6a4; Kca1-2; Gm10672
Summary
Enables voltage-gated potassium channel activity. Involved in potassium ion transmembrane transport; regulation of circadian sleep/wake cycle, non-REM sleep; and regulation of dopamine secretion. Acts upstream of or within optic nerve structural organization. Located in several cellular components, including axon; neuronal cell body membrane; and perikaryon. Is integral component of plasma membrane. Part of voltage-gated potassium channel complex. Is expressed in brain; heart ventricle; hindlimb muscle; and thalamus mantle layer. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 32. Orthologous to human KCNA2 (potassium voltage-gated channel subfamily A member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 17.1), cortex adult (RPKM 9.8) and 5 other tissues See more
Orthologs
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Genomic context

See Kcna2 in Genome Data Viewer
Location:
3 F2.3; 3 46.61 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (106998203..107022321)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (107090883..107115005)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene expressed sequence AI504432 Neighboring gene predicted gene, 38712 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 3 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 10 Neighboring gene chymosin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in neuronal action potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within optic nerve structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of circadian sleep/wake cycle, non-REM sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in axon initial segment IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axon terminus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in calyx of Held ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in juxtaparanode region of axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in juxtaparanode region of axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in juxtaparanode region of axon ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
part_of potassium channel complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
potassium voltage-gated channel subfamily A member 2
Names
MK2
voltage-gated potassium channel subunit Kv1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008417.5NP_032443.3  potassium voltage-gated channel subfamily A member 2

    See identical proteins and their annotated locations for NP_032443.3

    Status: VALIDATED

    Source sequence(s)
    AC121825, AI607461, AK044342
    Consensus CDS
    CCDS17733.1
    UniProtKB/Swiss-Prot
    P63141, Q8C8W4
    UniProtKB/TrEMBL
    A0A6P7R0B7, A0A8C6N684
    Related
    ENSMUSP00000041702.2, ENSMUST00000038695.6
    Conserved Domains (2) summary
    cl38908
    Location:33159
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:162420
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    106998203..107022321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501055.5XP_006501118.1  potassium voltage-gated channel subfamily A member 2 isoform X1

    See identical proteins and their annotated locations for XP_006501118.1

    UniProtKB/Swiss-Prot
    P63141, Q8C8W4
    UniProtKB/TrEMBL
    A0A6P7R0B7, A0A8C6N684
    Conserved Domains (2) summary
    cl38908
    Location:33159
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:162420
    Ion_trans; Ion transport protein
  2. XM_036162906.1XP_036018799.1  potassium voltage-gated channel subfamily A member 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8C8W4
    UniProtKB/TrEMBL
    A0A6P7R0B7, A0A8C6N684
    Conserved Domains (2) summary
    cl38908
    Location:33159
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:162420
    Ion_trans; Ion transport protein
  3. XM_006501049.5XP_006501112.1  potassium voltage-gated channel subfamily A member 2 isoform X1

    See identical proteins and their annotated locations for XP_006501112.1

    UniProtKB/Swiss-Prot
    P63141, Q8C8W4
    UniProtKB/TrEMBL
    A0A6P7R0B7, A0A8C6N684
    Related
    ENSMUSP00000143798.2, ENSMUST00000197470.5
    Conserved Domains (2) summary
    cl38908
    Location:33159
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:162420
    Ion_trans; Ion transport protein
  4. XM_006501052.5XP_006501115.1  potassium voltage-gated channel subfamily A member 2 isoform X1

    See identical proteins and their annotated locations for XP_006501115.1

    UniProtKB/Swiss-Prot
    P63141, Q8C8W4
    UniProtKB/TrEMBL
    A0A6P7R0B7, A0A8C6N684
    Conserved Domains (2) summary
    cl38908
    Location:33159
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:162420
    Ion_trans; Ion transport protein
  5. XM_006501051.5XP_006501114.1  potassium voltage-gated channel subfamily A member 2 isoform X1

    See identical proteins and their annotated locations for XP_006501114.1

    UniProtKB/Swiss-Prot
    P63141, Q8C8W4
    UniProtKB/TrEMBL
    A0A6P7R0B7, A0A8C6N684
    Conserved Domains (2) summary
    cl38908
    Location:33159
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:162420
    Ion_trans; Ion transport protein
  6. XM_006501053.5XP_006501116.1  potassium voltage-gated channel subfamily A member 2 isoform X1

    See identical proteins and their annotated locations for XP_006501116.1

    UniProtKB/Swiss-Prot
    P63141, Q8C8W4
    UniProtKB/TrEMBL
    A0A6P7R0B7, A0A8C6N684
    Conserved Domains (2) summary
    cl38908
    Location:33159
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:162420
    Ion_trans; Ion transport protein
  7. XM_006501050.4XP_006501113.1  potassium voltage-gated channel subfamily A member 2 isoform X1

    See identical proteins and their annotated locations for XP_006501113.1

    UniProtKB/Swiss-Prot
    P63141, Q8C8W4
    UniProtKB/TrEMBL
    A0A6P7R0B7, A0A8C6N684
    Related
    ENSMUSP00000142873.2, ENSMUST00000196403.2
    Conserved Domains (2) summary
    cl38908
    Location:33159
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:162420
    Ion_trans; Ion transport protein