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LONRF2 LON peptidase N-terminal domain and ring finger 2 [ Homo sapiens (human) ]

Gene ID: 164832, updated on 4-Dec-2022

Summary

Official Symbol
LONRF2provided by HGNC
Official Full Name
LON peptidase N-terminal domain and ring finger 2provided by HGNC
Primary source
HGNC:HGNC:24788
See related
Ensembl:ENSG00000170500 AllianceGenome:HGNC:24788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF192
Summary
Predicted to enable metal ion binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in adrenal (RPKM 18.3), brain (RPKM 16.1) and 10 other tissues See more
Orthologs
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Genomic context

See LONRF2 in Genome Data Viewer
Location:
2q11.2
Exon count:
14
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (100271875..100322501, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (100730785..100781377, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (100888337..100938963, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ALF transcription elongation factor 3 Neighboring gene fragile site, folic acid type, rare, fra(2)(q11.2) Neighboring gene long intergenic non-protein coding RNA 1104 Neighboring gene CYCS pseudogene 7 Neighboring gene carbohydrate sulfotransferase 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of LON peptidase N-terminal domain and ring finger 2 (LONRF2) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45273, MGC126711, MGC126713

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
LON peptidase N-terminal domain and RING finger protein 2
Names
RING finger protein 192
neuroblastoma apoptosis-related protease

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371783.1NP_001358712.1  LON peptidase N-terminal domain and RING finger protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC012493, AC104782
    Consensus CDS
    CCDS92818.1
    Conserved Domains (4) summary
    COG5574
    Location:137246
    PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:2151
    TPR; TPR repeat [structural motif]
    cd16514
    Location:203244
    RING2-HC_LONFs; RING finger 2, HC subclass, found in the LON peptidase N-terminal domain and RING finger proteins family
    pfam02190
    Location:295495
    LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
  2. NM_198461.4NP_940863.3  LON peptidase N-terminal domain and RING finger protein 2 isoform 1

    See identical proteins and their annotated locations for NP_940863.3

    Status: VALIDATED

    Source sequence(s)
    AC012493, AC104782
    Consensus CDS
    CCDS2046.2
    UniProtKB/Swiss-Prot
    Q1L5Z9, Q6ZSR4
    Related
    ENSP00000377086.3, ENST00000393437.8
    Conserved Domains (6) summary
    COG5574
    Location:380489
    PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:200225
    TPR; TPR repeat [structural motif]
    cd16513
    Location:143174
    RING1-HC_LONFs; RING finger 1, HC subclass, found in the LON peptidase N-terminal domain and RING finger proteins family
    cd16514
    Location:446487
    RING2-HC_LONFs; RING finger 2, HC subclass, found in the LON peptidase N-terminal domain and RING finger proteins family
    pfam02190
    Location:538738
    LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
    pfam13432
    Location:2792
    TPR_16; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    100271875..100322501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443537.1XP_047299493.1  LON peptidase N-terminal domain and RING finger protein 2 isoform X1

    Related
    ENSP00000386823.1, ENST00000409647.1
  2. XM_047443538.1XP_047299494.1  LON peptidase N-terminal domain and RING finger protein 2 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    100730785..100781377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)