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Jup junction plakoglobin [ Mus musculus (house mouse) ]

Gene ID: 16480, updated on 11-Apr-2024

Summary

Official Symbol
Jupprovided by MGI
Official Full Name
junction plakoglobinprovided by MGI
Primary source
MGI:MGI:96650
See related
Ensembl:ENSMUSG00000001552 AllianceGenome:MGI:96650
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PG; Ctnng; D930025P04Rik
Summary
Enables alpha-catenin binding activity. Acts upstream of or within cell-cell adhesion; desmosome assembly; and skin development. Located in several cellular components, including Z disc; adherens junction; and intermediate filament. Part of catenin complex. Is expressed in several structures, including alimentary system; musculature; nervous system; reproductive system; and sensory organ. Used to study arrhythmogenic right ventricular dysplasia 12 and epidermolytic hyperkeratosis. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); palmoplantar keratosis (multiple); renal cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human JUP (junction plakoglobin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 160.5), stomach adult (RPKM 151.6) and 23 other tissues See more
Orthologs
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Genomic context

See Jup in Genome Data Viewer
Location:
11 D; 11 63.47 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100259682..100288639, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100368856..100397839, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene huntingtin-associated protein 1 Neighboring gene predicted pseudogene 10039 Neighboring gene STARR-seq mESC enhancer starr_30729 Neighboring gene STARR-seq mESC enhancer starr_30732 Neighboring gene STARR-positive B cell enhancer ABC_E3999 Neighboring gene predicted gene 12348 Neighboring gene prolyl 3-hydroxylase family member 4 (non-enzymatic)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (10)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables alpha-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables alpha-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
 
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal protein-membrane anchor activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in bundle of His cell-Purkinje myocyte adhesion involved in cell communication ISO
Inferred from Sequence Orthology
more info
 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to indole-3-methanol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within desmosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in desmosome assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ventricular cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in apicolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of catenin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of catenin complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in cornified envelope IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in desmosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in desmosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in desmosome ISO
Inferred from Sequence Orthology
more info
 
located_in fascia adherens ISO
Inferred from Sequence Orthology
more info
 
part_of gamma-catenin-TCF7L2 complex ISO
Inferred from Sequence Orthology
more info
 
located_in intercalated disc ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
junction plakoglobin
Names
desmoplakin III
desmoplakin-3
gamma-catenin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010593.2NP_034723.1  junction plakoglobin

    See identical proteins and their annotated locations for NP_034723.1

    Status: VALIDATED

    Source sequence(s)
    AK145895, AL590968, CD555608
    Consensus CDS
    CCDS25420.1
    UniProtKB/Swiss-Prot
    Q02257, Q8CGD3
    Related
    ENSMUSP00000001592.9, ENSMUST00000001592.15
    Conserved Domains (4) summary
    smart00185
    Location:341381
    ARM; Armadillo/beta-catenin-like repeats
    PLN03200
    Location:328658
    PLN03200; cellulose synthase-interactive protein; Provisional
    sd00043
    Location:393418
    ARM; armadillo repeat [structural motif]
    pfam01602
    Location:120289
    Adaptin_N; Adaptin N terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100259682..100288639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245605.2XP_030101465.1  junction plakoglobin isoform X1

    UniProtKB/Swiss-Prot
    Q02257, Q8CGD3
    Conserved Domains (4) summary
    smart00185
    Location:341381
    ARM; Armadillo/beta-catenin-like repeats
    PLN03200
    Location:328658
    PLN03200; cellulose synthase-interactive protein; Provisional
    sd00043
    Location:393418
    ARM; armadillo repeat [structural motif]
    pfam01602
    Location:120289
    Adaptin_N; Adaptin N terminal region
  2. XM_006532315.5XP_006532378.1  junction plakoglobin isoform X1

    See identical proteins and their annotated locations for XP_006532378.1

    UniProtKB/Swiss-Prot
    Q02257, Q8CGD3
    Related
    ENSMUSP00000103026.2, ENSMUST00000107403.2
    Conserved Domains (4) summary
    smart00185
    Location:341381
    ARM; Armadillo/beta-catenin-like repeats
    PLN03200
    Location:328658
    PLN03200; cellulose synthase-interactive protein; Provisional
    sd00043
    Location:393418
    ARM; armadillo repeat [structural motif]
    pfam01602
    Location:120289
    Adaptin_N; Adaptin N terminal region
  3. XM_006532316.1XP_006532379.1  junction plakoglobin isoform X1

    See identical proteins and their annotated locations for XP_006532379.1

    UniProtKB/Swiss-Prot
    Q02257, Q8CGD3
    Conserved Domains (4) summary
    smart00185
    Location:341381
    ARM; Armadillo/beta-catenin-like repeats
    PLN03200
    Location:328658
    PLN03200; cellulose synthase-interactive protein; Provisional
    sd00043
    Location:393418
    ARM; armadillo repeat [structural motif]
    pfam01602
    Location:120289
    Adaptin_N; Adaptin N terminal region