Format

Send to:

Choose Destination

DAW1 dynein assembly factor with WD repeats 1 [ Homo sapiens (human) ]

Gene ID: 164781, updated on 23-Nov-2021

Summary

Official Symbol
DAW1provided by HGNC
Official Full Name
dynein assembly factor with WD repeats 1provided by HGNC
Primary source
HGNC:HGNC:26383
See related
Ensembl:ENSG00000123977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ODA16; WDR69
Expression
Restricted expression toward testis (RPKM 20.0) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See DAW1 in Genome Data Viewer
Location:
2q36.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (227871631..227924347)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (228736347..228789060)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 20 Neighboring gene teratocarcinoma-derived growth factor 1 pseudogene 2 Neighboring gene uncharacterized LOC105373918 Neighboring gene SPHK1 interactor, AKAP domain containing Neighboring gene uncharacterized LOC107985993

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25955

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in cerebrospinal fluid circulation IEA
Inferred from Electronic Annotation
more info
 
involved_in determination of left/right symmetry IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of localization in cell IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in outer dynein arm assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dynein assembly factor with WDR repeat domains 1
Names
WD repeat domain 69
WD repeat-containing protein 69
outer row dynein assembly 16 homolog
outer row dynein assembly protein 16 homolog
testis tissue sperm-binding protein Li 93mP

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330004.2NP_001316933.1  dynein assembly factor with WDR repeat domains 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' end compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC073065, AK097409, AK301861, BM981084
    UniProtKB/Swiss-Prot
    Q8N136
    UniProtKB/TrEMBL
    B4DX89, G5EA46
    Conserved Domains (4) summary
    smart00320
    Location:66105
    WD40; WD40 repeats
    COG2319
    Location:23399
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:111400
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:122160
    7WD40; WD40 repeat [structural motif]
  2. NM_178821.3NP_849143.1  dynein assembly factor with WDR repeat domains 1 isoform 1

    See identical proteins and their annotated locations for NP_849143.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK097409, BM981084
    Consensus CDS
    CCDS2470.1
    UniProtKB/Swiss-Prot
    Q8N136
    UniProtKB/TrEMBL
    A0A140VKH6
    Related
    ENSP00000311899.2, ENST00000309931.3
    Conserved Domains (4) summary
    smart00320
    Location:81120
    WD40; WD40 repeats
    COG1503
    Location:2290
    eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]
    cd00200
    Location:126415
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:137175
    7WD40; WD40 repeat [structural motif]

RNA

  1. NR_138459.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC073065, AK127882, BM981084

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    227871631..227924347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003490.1XP_016858979.1  dynein assembly factor with WDR repeat domains 1 isoform X1

Support Center