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Ajuba ajuba LIM protein [ Mus musculus (house mouse) ]

Gene ID: 16475, updated on 24-Jan-2023

Summary

Official Symbol
Ajubaprovided by MGI
Official Full Name
ajuba LIM proteinprovided by MGI
Primary source
MGI:MGI:1341886
See related
Ensembl:ENSMUSG00000022178 AllianceGenome:MGI:1341886
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Jub
Summary
Enables several functions, including actin filament binding activity; alpha-catenin binding activity; and transcription corepressor activity. Acts upstream of or within several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; positive regulation of intracellular signal transduction; and regulation of cellular biosynthetic process. Located in several cellular components, including cytosol; focal adhesion; and lamellipodium. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; sensory organ; and tooth. Orthologous to human AJUBA (ajuba LIM protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 26.2), ovary adult (RPKM 18.9) and 24 other tissues See more
Orthologs
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Genomic context

See Ajuba in Genome Data Viewer
Location:
14; 14 C2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54804926..54815118, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54567469..54577661, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53858 Neighboring gene HAUS augmin-like complex, subunit 4 Neighboring gene RIKEN cDNA 4931414P19 gene Neighboring gene U6 small nuclear RNA, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables alpha-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables alpha-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within RNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glycerophospholipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within miRNA-mediated gene silencing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cellular biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of miRNA-mediated gene silencing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of miRNA-mediated gene silencing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within wound healing, spreading of epidermal cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in P-body ISO
Inferred from Sequence Orthology
more info
 
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
LIM domain-containing protein ajuba
Names
protein ajuba

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010590.5NP_034720.2  LIM domain-containing protein ajuba

    See identical proteins and their annotated locations for NP_034720.2

    Status: VALIDATED

    Source sequence(s)
    AC164433
    Consensus CDS
    CCDS27093.1
    UniProtKB/Swiss-Prot
    P97472, Q91XC0
    Related
    ENSMUSP00000056977.9, ENSMUST00000054487.10
    Conserved Domains (3) summary
    cd09352
    Location:347400
    LIM1_Ajuba_like; The first LIM domain of Ajuba-like proteins
    cd09355
    Location:412464
    LIM2_Ajuba_like; The second LIM domain of Ajuba-like proteins
    cd09438
    Location:472533
    LIM3_Ajuba_like; The third LIM domain of Ajuba-like proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    54804926..54815118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)