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TTLL8 tubulin tyrosine ligase like 8 [ Homo sapiens (human) ]

Gene ID: 164714, updated on 26-Oct-2022

Summary

Official Symbol
TTLL8provided by HGNC
Official Full Name
tubulin tyrosine ligase like 8provided by HGNC
Primary source
HGNC:HGNC:34000
See related
Ensembl:ENSG00000138892 MIM:619193; AllianceGenome:HGNC:34000
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable protein-glycine ligase activity, initiating. Predicted to be involved in protein polyglycylation. Predicted to act upstream of or within cilium assembly. Predicted to be located in axoneme and microtubule cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 2.3) See more
Orthologs
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Genomic context

See TTLL8 in Genome Data Viewer
Location:
22q13.33
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (50018575..50058227, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (50523480..50564897, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50457004..50496656, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene microRNA 6821 Neighboring gene Pim-3 proto-oncogene, serine/threonine kinase Neighboring gene interleukin 17 receptor E like Neighboring gene modulator of VRAC current 1 Neighboring gene Mov10 like RISC complex RNA helicase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-glycine ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-glycine ligase activity TAS
Traceable Author Statement
more info
 
enables protein-glycine ligase activity, initiating IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-glycine ligase activity, initiating ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein polyglycylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein polyglycylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein polyglycylation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in axoneme ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microtubule cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein monoglycylase TTLL8
Names
tubulin tyrosine ligase-like family, member 8
tubulin--tyrosine ligase-like protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001350317.3NP_001337246.1  protein monoglycylase TTLL8

    Status: VALIDATED

    Source sequence(s)
    AL022327
    Consensus CDS
    CCDS93183.1
    Related
    ENSP00000392252.2, ENST00000433387.2
    Conserved Domains (1) summary
    pfam03133
    Location:348574
    TTL; Tubulin-tyrosine ligase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    50018575..50058227 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452173.1XP_024307941.1  protein monoglycylase TTLL8 isoform X2

    Conserved Domains (1) summary
    pfam03133
    Location:347573
    TTL; Tubulin-tyrosine ligase family
  2. XM_024452172.1XP_024307940.1  protein monoglycylase TTLL8 isoform X1

    Conserved Domains (1) summary
    pfam03133
    Location:348574
    TTL; Tubulin-tyrosine ligase family
  3. XM_024452174.1XP_024307942.1  protein monoglycylase TTLL8 isoform X3

    Conserved Domains (1) summary
    pfam03133
    Location:217443
    TTL; Tubulin-tyrosine ligase family
  4. XM_024452177.1XP_024307945.1  protein monoglycylase TTLL8 isoform X4

    Conserved Domains (1) summary
    pfam03133
    Location:137363
    TTL; Tubulin-tyrosine ligase family
  5. XM_024452175.1XP_024307943.1  protein monoglycylase TTLL8 isoform X4

    Conserved Domains (1) summary
    pfam03133
    Location:137363
    TTL; Tubulin-tyrosine ligase family
  6. XM_024452176.1XP_024307944.1  protein monoglycylase TTLL8 isoform X4

    Conserved Domains (1) summary
    pfam03133
    Location:137363
    TTL; Tubulin-tyrosine ligase family
  7. XM_047441179.1XP_047297135.1  protein monoglycylase TTLL8 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    50523480..50564897 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080447.1: Suppressed sequence

    Description
    NM_001080447.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.