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Jarid2 jumonji and AT-rich interaction domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 16468, updated on 21-Apr-2024

Summary

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Official Symbol
Jarid2provided by MGI
Official Full Name
jumonji and AT-rich interaction domain containing 2provided by MGI
Primary source
MGI:MGI:104813
See related
Ensembl:ENSMUSG00000038518 AllianceGenome:MGI:104813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Jmj; jumonji
Summary
Enables several functions, including chromatin binding activity; ubiquitin binding activity; and ubiquitin modification-dependent histone binding activity. Involved in negative regulation of transcription by RNA polymerase II; regulation of histone methylation; and stem cell differentiation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; hematopoietic or lymphoid organ development; and regulation of gene expression. Located in nucleus. Part of ESC/E(Z) complex. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human JARID2 (jumonji and AT-rich interaction domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 13.8), CNS E14 (RPKM 9.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A5; 13 21.66 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (44881817..45075119)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (44730774..44921643)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:44630976-44631169 Neighboring gene STARR-seq mESC enhancer starr_34362 Neighboring gene STARR-seq mESC enhancer starr_34363 Neighboring gene predicted gene, 34276 Neighboring gene predicted gene, 40931 Neighboring gene STARR-seq mESC enhancer starr_34369 Neighboring gene STARR-seq mESC enhancer starr_34371 Neighboring gene STARR-positive B cell enhancer ABC_E10792 Neighboring gene STARR-seq mESC enhancer starr_34375 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:44825976-44826085 Neighboring gene STARR-positive B cell enhancer ABC_E9399 Neighboring gene STARR-positive B cell enhancer ABC_E5391 Neighboring gene STARR-seq mESC enhancer starr_34376 Neighboring gene STARR-seq mESC enhancer starr_34381 Neighboring gene STARR-seq mESC enhancer starr_34384 Neighboring gene dystrobrevin binding protein 1 Neighboring gene predicted gene, 23104

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. JARID2 and the PRC2 complex regulate skeletal muscle differentiation through regulation of canonical Wnt signaling. Adhikari A, et al. Epigenetics Chromatin, 2018 Aug 17. PMID 30119689, Free PMC Article
  2. Jarid2 Coordinates Nanog Expression and PCP/Wnt Signaling Required for Efficient ESC Differentiation and Early Embryo Development. Landeira D, et al. Cell Rep, 2015 Jul 28. PMID 26190104, Free PMC Article
  3. Polycomb repressive complex 2 in embryonic stem cells: an overview. Jones A, et al. Protein Cell, 2010 Dec. PMID 21213100, Free PMC Article
  4. Nitric oxide induces gene expression of Jumonji and retinoblastoma 2 protein while reducing expression of atrial natriuretic peptide precursor type B in cardiomyocytes. Klassen SS, et al. Folia Biol (Praha), 2008. PMID 18498724
  5. Generation of a conditional null allele of jumonji. Mysliwiec MR, et al. Genesis, 2006 Sep. PMID 16900512, Free PMC Article

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-155 promotes compensatory lung growth by inhibiting JARID2 activation of CD34+ endothelial progenitor cells.
    Title: MiR-155 promotes compensatory lung growth by inhibiting JARID2 activation of CD34+ endothelial progenitor cells.
  2. Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1.
    Title: Jarid2 promotes temporal progression of retinal progenitors via repression of Foxp1.
  3. Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation.
    Title: Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation.
  4. Polycomb regulation is coupled to cell cycle transition in pluripotent stem cells.
    Title: Polycomb regulation is coupled to cell cycle transition in pluripotent stem cells.
  5. JARID2 and the PRC2 complex regulate skeletal muscle proliferation in a precise manner that involves the repression of cyclin D1, thus restraining proliferation and repressing RB1, which is required for mitotic exit and terminal differentiation
    Title: JARID2 and the PRC2 complex regulate the cell cycle in skeletal muscle.
  6. This study demonstrates that ablation of Jarid2 in cardiomyocytes results in dilated cardiomyopathy and suggest that Jarid2 plays important roles in cardiomyocyte maturation during neonatal stages.
    Title: Myocardial-specific ablation of Jumonji and AT-rich interaction domain-containing 2 (Jarid2) leads to dilated cardiomyopathy in mice.
  7. In this study, genetic mouse models and patient-derived xenografts demonstrated that JARID2 acts as a tumor suppressor in chronic myeloid disorders.
    Title: JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells.
  8. The deletion of Jarid2 by Nkx2.5-Cre mice (Jarid2(Nkx)) caused cardiac malformations including ventricular septal defects, thin myocardium, hypertrabeculation, and neonatal lethality. Jarid2(Nkx) mice exhibited elevated expression of neural genes, cardiac jelly, and other key factors including Isl1 and Bmp10 in the developing heart.
    Title: Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development.
  9. JARID2 regulates muscle differentiation by modulating Wnt signaling through direct repression of SFRP1.
    Title: JARID2 and the PRC2 complex regulate skeletal muscle differentiation through regulation of canonical Wnt signaling.
  10. These findings ascribe a critical function to Jarid2 and define a key mechanism that links PRC1 and PRC2 in the establishment of Polycomb domains.
    Title: Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT contributes_to histone H3K27 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to histone H3K27 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables histone demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables histone demethylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ubiquitin-modified histone reader activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in facultative heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within protein localization to pericentric heterochromatin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within random inactivation of X chromosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spleen development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within thymus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of histone methyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein Jumonji
Names
jumonji, AT rich interactive domain 2
jumonji/ARID domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205043.2 → NP_001191972.1  protein Jumonji isoform 1

    See identical proteins and their annotated locations for NP_001191972.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC166074, AC170597
    Consensus CDS
    CCDS36646.1
    UniProtKB/Swiss-Prot
    Q3TPU4, Q3UHS7, Q62315, Q99LD1
    UniProtKB/TrEMBL
    G3UZT8
    Related
    ENSMUSP00000134205.2, ENSMUST00000173246.8
    Conserved Domains (4) summary
    smart00545
    Location:554 → 595
    JmjN; Small domain found in the jumonji family of transcription factors
    cd16870
    Location:618 → 729
    ARID_JARD2; ARID/BRIGHT DNA binding domain of Jumonji/ARID domain-containing protein 2 (JARID2) and similar proteins
    pfam02373
    Location:914 → 1029
    JmjC; JmjC domain, hydroxylase
    pfam02928
    Location:1137 → 1190
    zf-C5HC2; C5HC2 zinc finger

  2. NM_001205044.1 → NP_001191973.1  protein Jumonji isoform 1

    See identical proteins and their annotated locations for NP_001191973.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC166074, AC170597
    Consensus CDS
    CCDS36646.1
    UniProtKB/Swiss-Prot
    Q3TPU4, Q3UHS7, Q62315, Q99LD1
    UniProtKB/TrEMBL
    G3UZT8
    Related
    ENSMUSP00000134675.2, ENSMUST00000173704.8
    Conserved Domains (4) summary
    smart00545
    Location:554 → 595
    JmjN; Small domain found in the jumonji family of transcription factors
    cd16870
    Location:618 → 729
    ARID_JARD2; ARID/BRIGHT DNA binding domain of Jumonji/ARID domain-containing protein 2 (JARID2) and similar proteins
    pfam02373
    Location:914 → 1029
    JmjC; JmjC domain, hydroxylase
    pfam02928
    Location:1137 → 1190
    zf-C5HC2; C5HC2 zinc finger

  3. NM_001360281.1 → NP_001347210.1  protein Jumonji isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166074, AC170597
    UniProtKB/TrEMBL
    Q1LZL9
    Conserved Domains (5) summary
    smart00545
    Location:382 → 423
    JmjN; Small domain found in the jumonji family of transcription factors
    pfam02373
    Location:742 → 857
    JmjC; JmjC domain, hydroxylase
    cd16870
    Location:446 → 557
    ARID_JARD2; ARID/BRIGHT DNA binding domain of Jumonji/ARID domain-containing protein 2 (JARID2) and similar proteins
    pfam02928
    Location:965 → 1018
    zf-C5HC2; C5HC2 zinc finger
    pfam09422
    Location:218 → 390
    WTX; WTX protein

  4. NM_021878.3 → NP_068678.1  protein Jumonji isoform 1

    See identical proteins and their annotated locations for NP_068678.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC166074, AC170597, BC052444
    Consensus CDS
    CCDS36646.1
    UniProtKB/Swiss-Prot
    Q3TPU4, Q3UHS7, Q62315, Q99LD1
    UniProtKB/TrEMBL
    G3UZT8
    Related
    ENSMUSP00000037774.8, ENSMUST00000044608.14
    Conserved Domains (4) summary
    smart00545
    Location:554 → 595
    JmjN; Small domain found in the jumonji family of transcription factors
    cd16870
    Location:618 → 729
    ARID_JARD2; ARID/BRIGHT DNA binding domain of Jumonji/ARID domain-containing protein 2 (JARID2) and similar proteins
    pfam02373
    Location:914 → 1029
    JmjC; JmjC domain, hydroxylase
    pfam02928
    Location:1137 → 1190
    zf-C5HC2; C5HC2 zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    44881817..45075119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157864.1 → XP_036013757.1  protein Jumonji isoform X1

    UniProtKB/Swiss-Prot
    Q3TPU4, Q3UHS7, Q62315, Q99LD1
    UniProtKB/TrEMBL
    G3UZT8
    Conserved Domains (4) summary
    smart00545
    Location:554 → 595
    JmjN; Small domain found in the jumonji family of transcription factors
    cd16870
    Location:618 → 729
    ARID_JARD2; ARID/BRIGHT DNA binding domain of Jumonji/ARID domain-containing protein 2 (JARID2) and similar proteins
    pfam02373
    Location:914 → 1029
    JmjC; JmjC domain, hydroxylase
    pfam02928
    Location:1137 → 1190
    zf-C5HC2; C5HC2 zinc finger

  2. XM_036157863.1 → XP_036013756.1  protein Jumonji isoform X1

    UniProtKB/Swiss-Prot
    Q3TPU4, Q3UHS7, Q62315, Q99LD1
    UniProtKB/TrEMBL
    G3UZT8
    Related
    ENSMUSP00000134630.2, ENSMUST00000173906.3
    Conserved Domains (4) summary
    smart00545
    Location:554 → 595
    JmjN; Small domain found in the jumonji family of transcription factors
    cd16870
    Location:618 → 729
    ARID_JARD2; ARID/BRIGHT DNA binding domain of Jumonji/ARID domain-containing protein 2 (JARID2) and similar proteins
    pfam02373
    Location:914 → 1029
    JmjC; JmjC domain, hydroxylase
    pfam02928
    Location:1137 → 1190
    zf-C5HC2; C5HC2 zinc finger

  3. XM_006516859.4 → XP_006516922.1  protein Jumonji isoform X3

    See identical proteins and their annotated locations for XP_006516922.1

    UniProtKB/TrEMBL
    Q1LZL9
    Conserved Domains (5) summary
    smart00545
    Location:382 → 423
    JmjN; Small domain found in the jumonji family of transcription factors
    pfam02373
    Location:742 → 857
    JmjC; JmjC domain, hydroxylase
    cd16870
    Location:446 → 557
    ARID_JARD2; ARID/BRIGHT DNA binding domain of Jumonji/ARID domain-containing protein 2 (JARID2) and similar proteins
    pfam02928
    Location:965 → 1018
    zf-C5HC2; C5HC2 zinc finger
    pfam09422
    Location:218 → 390
    WTX; WTX protein

  4. XM_006516858.5 → XP_006516921.1  protein Jumonji isoform X2

    See identical proteins and their annotated locations for XP_006516921.1

    UniProtKB/TrEMBL
    G3UZT8
    Conserved Domains (5) summary
    smart00545
    Location:516 → 557
    JmjN; Small domain found in the jumonji family of transcription factors
    pfam02373
    Location:876 → 991
    JmjC; JmjC domain, hydroxylase
    cd16870
    Location:580 → 691
    ARID_JARD2; ARID/BRIGHT DNA binding domain of Jumonji/ARID domain-containing protein 2 (JARID2) and similar proteins
    pfam02928
    Location:1099 → 1152
    zf-C5HC2; C5HC2 zinc finger
    pfam09422
    Location:352 → 524
    WTX; WTX protein

  5. XM_006516860.4 → XP_006516923.1  protein Jumonji isoform X3

    See identical proteins and their annotated locations for XP_006516923.1

    UniProtKB/TrEMBL
    Q1LZL9
    Conserved Domains (5) summary
    smart00545
    Location:382 → 423
    JmjN; Small domain found in the jumonji family of transcription factors
    pfam02373
    Location:742 → 857
    JmjC; JmjC domain, hydroxylase
    cd16870
    Location:446 → 557
    ARID_JARD2; ARID/BRIGHT DNA binding domain of Jumonji/ARID domain-containing protein 2 (JARID2) and similar proteins
    pfam02928
    Location:965 → 1018
    zf-C5HC2; C5HC2 zinc finger
    pfam09422
    Location:218 → 390
    WTX; WTX protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62315.1 GenPept UniProtKB/Swiss-Prot:Q62315

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