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WBP2NL WBP2 N-terminal like [ Homo sapiens (human) ]

Gene ID: 164684, updated on 5-Aug-2022

Summary

Official Symbol
WBP2NLprovided by HGNC
Official Full Name
WBP2 N-terminal likeprovided by HGNC
Primary source
HGNC:HGNC:28389
See related
Ensembl:ENSG00000183066 MIM:610981; AllianceGenome:HGNC:28389
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAWP; GRAMD7
Summary
WBP2NL is a sperm-specific WW domain-binding protein that promotes meiotic resumption and pronuclear development during oocyte fertilization (Wu et al., 2007 [PubMed 17289678]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in testis (RPKM 7.0) and thyroid (RPKM 0.3) See more
Orthologs
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Genomic context

See WBP2NL in Genome Data Viewer
Location:
22q13.2
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (41998788..42058371)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (42478395..42508069)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (42394792..42424479)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene centromere protein M Neighboring gene small integral membrane protein 45 Neighboring gene septin 3 Neighboring gene solute carrier family 25 member 5 pseudogene 1 Neighboring gene CYP2D6 downstream enhancer Neighboring gene uncharacterized LOC107985551 Neighboring gene alpha-N-acetylgalactosaminidase Neighboring gene small nucleolar RNA, C/D box 13 pseudogene 1 Neighboring gene PH domain containing endocytic trafficking adaptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26145, MGC26816

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables WW domain binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in egg activation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in female pronucleus assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in male pronucleus assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT involved_in regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear theca ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm head IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
postacrosomal sheath WW domain-binding protein
Names
WW domain-binding protein 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152613.3NP_689826.2  postacrosomal sheath WW domain-binding protein

    See identical proteins and their annotated locations for NP_689826.2

    Status: VALIDATED

    Source sequence(s)
    AK128138, BC022546, Z99716
    Consensus CDS
    CCDS14029.1
    UniProtKB/Swiss-Prot
    Q6ICG8, Q8TBF3
    Related
    ENSP00000332983.9, ENST00000328823.13
    Conserved Domains (2) summary
    cd13214
    Location:39134
    PH-GRAM_WBP2; WW binding protein 2 (WB2) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam10349
    Location:103263
    WWbp; WW-domain ligand protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    41998788..42058371
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441173.1XP_047297129.1  postacrosomal sheath WW domain-binding protein isoform X1

  2. XM_047441175.1XP_047297131.1  postacrosomal sheath WW domain-binding protein isoform X2

    UniProtKB/Swiss-Prot
    Q8TBF3
    Related
    ENSP00000401002.1, ENST00000436265.5
  3. XM_047441172.1XP_047297128.1  postacrosomal sheath WW domain-binding protein isoform X1

  4. XM_047441174.1XP_047297130.1  postacrosomal sheath WW domain-binding protein isoform X2

    UniProtKB/Swiss-Prot
    Q8TBF3
    Related
    ENSP00000328800.5, ENST00000329620.9
  5. XM_047441178.1XP_047297134.1  postacrosomal sheath WW domain-binding protein isoform X3

  6. XM_047441177.1XP_047297133.1  postacrosomal sheath WW domain-binding protein isoform X3

    Related
    ENSP00000442447.1, ENST00000543212.5
  7. XM_047441176.1XP_047297132.1  postacrosomal sheath WW domain-binding protein isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    42478395..42508069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)