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Itln1 intelectin 1 (galactofuranose binding) [ Mus musculus (house mouse) ]

Gene ID: 16429, updated on 12-Feb-2024

Summary

Official Symbol
Itln1provided by MGI
Official Full Name
intelectin 1 (galactofuranose binding)provided by MGI
Primary source
MGI:MGI:1333831
See related
Ensembl:ENSMUSG00000038209 AllianceGenome:MGI:1333831
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lfr; IntL; Itln; Itln2; Itln3; Itln5; Itlna
Summary
Enables oligosaccharide binding activity. Involved in response to nematode. Located in brush border membrane and membrane raft. Is expressed in several structures, including brain; eye; genitourinary system; gut; and immune system. Orthologous to several human genes including ITLN1 (intelectin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 1139.6), small intestine adult (RPKM 561.6) and 1 other tissue See more
Orthologs
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Genomic context

See Itln1 in Genome Data Viewer
Location:
1 H3; 1 79.49 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171345691..171362893, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171518123..171535325, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E996 Neighboring gene predicted gene, 24871 Neighboring gene Aly/REF export factor 2 Neighboring gene predicted gene, 37450 Neighboring gene STARR-positive B cell enhancer ABC_E9497 Neighboring gene predicted gene, 35200 Neighboring gene STARR-seq mESC enhancer starr_03041 Neighboring gene CD244 molecule A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC183671, MGC183706

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables carbohydrate binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oligosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables oligosaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables oligosaccharide binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotrimerization ISO
Inferred from Sequence Orthology
more info
 
involved_in response to nematode IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in brush border membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
intelectin-1a
Names
calcium-dependent galactosyl-specific lectin
galactofuranose-binding lectin
intelectin 2
intelectin 5
intelectin a
intestinal lactoferrin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010584.3NP_034714.1  intelectin-1a precursor

    See identical proteins and their annotated locations for NP_034714.1

    Status: VALIDATED

    Source sequence(s)
    AK007447, AY157364
    Consensus CDS
    CCDS35777.1
    UniProtKB/Swiss-Prot
    O88310, Q5IWS3
    UniProtKB/TrEMBL
    B9EK97, D9J349
    Related
    ENSMUSP00000043837.7, ENSMUST00000043094.13
    Conserved Domains (1) summary
    cl00085
    Location:3782
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    171345691..171362893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496676.1XP_006496739.1  intelectin-1a isoform X1

    UniProtKB/TrEMBL
    B9EK97
    Conserved Domains (1) summary
    cl00085
    Location:3782
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...