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Itih1 inter-alpha trypsin inhibitor, heavy chain 1 [ Mus musculus (house mouse) ]

Gene ID: 16424, updated on 12-May-2024

Summary

Official Symbol
Itih1provided by MGI
Official Full Name
inter-alpha trypsin inhibitor, heavy chain 1provided by MGI
Primary source
MGI:MGI:96618
See related
Ensembl:ENSMUSG00000006529 AllianceGenome:MGI:96618
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Intin1; Itih-1; ITI-HC1
Summary
This gene encodes a heavy chain of inter-alpha trypsin inhibitor (IaI) family of plasma serine protease inhibitors. IaI proteins are protein-glycosaminoglycan-protein complexes comprised of two heavy chains and a light chain. The encoded protein covalently associates with the light chain via a chondroitin sulfate moiety. Intravenous administration of the encoded protein improved survival of mice after infection with Escherichia coli. This gene is located adjacent to two other IaI heavy chain genes. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature protein. [provided by RefSeq, Oct 2015]
Expression
Biased expression in liver adult (RPKM 180.0), liver E18 (RPKM 77.5) and 2 other tissues See more
Orthologs
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Genomic context

See Itih1 in Genome Data Viewer
Location:
14 B; 14 19.09 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30651137..30665246, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (30929180..30943289, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene inter alpha-trypsin inhibitor, heavy chain 4 Neighboring gene inter-alpha trypsin inhibitor, heavy chain 3 Neighboring gene STARR-positive B cell enhancer ABC_E3106 Neighboring gene predicted gene, 41121 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
inter-alpha-trypsin inhibitor heavy chain H1
Names
inter-alpha (globulin) inhibitor, H1 polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306078.1NP_001293007.1  inter-alpha-trypsin inhibitor heavy chain H1 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This variant encodes isoform 2, which is longer than isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1.
    Source sequence(s)
    AK149500, CT025528
    Consensus CDS
    CCDS79287.1
    UniProtKB/TrEMBL
    F8WJ05, Q8K159
    Related
    ENSMUSP00000006704.8, ENSMUST00000006704.17
    Conserved Domains (5) summary
    smart00609
    Location:34167
    VIT; Vault protein Inter-alpha-Trypsin domain
    cd01461
    Location:290471
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    TIGR03788
    Location:59610
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam06668
    Location:706891
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
    cl19107
    Location:526620
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
  2. NM_008406.3NP_032432.2  inter-alpha-trypsin inhibitor heavy chain H1 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_032432.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AK149500
    Consensus CDS
    CCDS49435.1
    UniProtKB/Swiss-Prot
    Q3UEI9, Q61702
    UniProtKB/TrEMBL
    Q8K159
    Related
    ENSMUSP00000126449.2, ENSMUST00000163118.2
    Conserved Domains (5) summary
    smart00609
    Location:34163
    VIT; Vault protein Inter-alpha-Trypsin domain
    cd01461
    Location:286467
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    TIGR03788
    Location:55606
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam06668
    Location:702887
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
    cl19107
    Location:522616
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    30651137..30665246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518584.3XP_006518647.1  inter-alpha-trypsin inhibitor heavy chain H1 isoform X1

    UniProtKB/TrEMBL
    Q91WU7
    Conserved Domains (3) summary
    cd01461
    Location:147328
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    pfam06668
    Location:562748
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
    cl02699
    Location:124
    VIT; Vault protein inter-alpha-trypsin domain