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Cd47 CD47 antigen (Rh-related antigen, integrin-associated signal transducer) [ Mus musculus (house mouse) ]

Gene ID: 16423, updated on 26-Jun-2024

Summary

Official Symbol
Cd47provided by MGI
Official Full Name
CD47 antigen (Rh-related antigen, integrin-associated signal transducer)provided by MGI
Primary source
MGI:MGI:96617
See related
Ensembl:ENSMUSG00000055447 AllianceGenome:MGI:96617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IAP; Itgp; 9130415E20Rik; B430305P08Rik
Summary
Predicted to enable protein binding activity involved in heterotypic cell-cell adhesion and thrombospondin receptor activity. Involved in regulation of nitric oxide biosynthetic process. Acts upstream of or within several processes, including monocyte aggregation; opsonization; and positive regulation of phagocytosis. Located in extracellular exosome. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human CD47 (CD47 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 39.9), liver E14.5 (RPKM 35.9) and 28 other tissues See more
Orthologs
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Genomic context

See Cd47 in Genome Data Viewer
Location:
16 B5; 16 31.23 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (49671691..49732799)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (49851328..49912503)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 57 Neighboring gene STARR-positive B cell enhancer ABC_E10908 Neighboring gene predicted gene 15518 Neighboring gene STARR-positive B cell enhancer ABC_E9165 Neighboring gene STARR-seq mESC enhancer starr_40971 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:49818780-49819076 Neighboring gene predicted gene, 16619 Neighboring gene predicted gene 4633 Neighboring gene STARR-seq mESC enhancer starr_40972 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:49856157-49856266 Neighboring gene STARR-positive B cell enhancer mm9_chr16:49907578-49907878 Neighboring gene STARR-seq mESC enhancer starr_40973 Neighboring gene predicted gene 5486 Neighboring gene STARR-positive B cell enhancer ABC_E7456 Neighboring gene STARR-positive B cell enhancer mm9_chr16:49970625-49970926 Neighboring gene STARR-positive B cell enhancer mm9_chr16:49971104-49971405 Neighboring gene predicted gene, 19723 Neighboring gene STARR-positive B cell enhancer mm9_chr16:49982479-49982780 Neighboring gene predicted gene 6936

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell-cell adhesion mediator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding involved in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
enables thrombospondin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thrombospondin receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within ATP export ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interleukin-12 ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within monocyte aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within opsonization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of monocyte extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of Fc receptor mediated stimulatory signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synapse pruning IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synapse pruning IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of synapse pruning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular exosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
leukocyte surface antigen CD47
Names
Rh-related antigen
integrin-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368415.1NP_001355344.1  leukocyte surface antigen CD47 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC107830, AK151922, BP757719
    UniProtKB/Swiss-Prot
    Q61735, Q921Z2
    UniProtKB/TrEMBL
    E5Q371, Q3U967
    Related
    ENSMUSP00000155684.2, ENSMUST00000230836.2
    Conserved Domains (2) summary
    pfam04549
    Location:142290
    CD47; CD47 transmembrane region
    cd16090
    Location:26131
    IgV_CD47; Immunoglobulin variable domain (IgV) in CD47
  2. NM_001368416.1NP_001355345.1  leukocyte surface antigen CD47 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC107830, AC158166
    Consensus CDS
    CCDS88938.1
    UniProtKB/TrEMBL
    A0A2R8W6P0, E5Q371
    Related
    ENSMUSP00000155178.2, ENSMUST00000230641.2
    Conserved Domains (2) summary
    pfam04549
    Location:163311
    CD47; CD47 transmembrane region
    cd16090
    Location:26131
    IgV_CD47; Immunoglobulin variable domain (IgV) in CD47
  3. NM_001368417.1NP_001355346.1  leukocyte surface antigen CD47 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC107830, AC158166
    UniProtKB/TrEMBL
    E5Q371
    Related
    ENSMUSP00000155856.2, ENSMUST00000229101.2
    Conserved Domains (2) summary
    pfam04549
    Location:163311
    CD47; CD47 transmembrane region
    cd16090
    Location:26131
    IgV_CD47; Immunoglobulin variable domain (IgV) in CD47
  4. NM_001368418.1NP_001355347.1  leukocyte surface antigen CD47 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC107830, AC158166
    Consensus CDS
    CCDS88939.1
    UniProtKB/TrEMBL
    A0A2R8VK70, E5Q371
    Related
    ENSMUSP00000155289.2, ENSMUST00000229206.2
    Conserved Domains (2) summary
    pfam04549
    Location:142290
    CD47; CD47 transmembrane region
    cd16090
    Location:26131
    IgV_CD47; Immunoglobulin variable domain (IgV) in CD47
  5. NM_010581.3NP_034711.1  leukocyte surface antigen CD47 isoform 4 precursor

    See identical proteins and their annotated locations for NP_034711.1

    Status: VALIDATED

    Source sequence(s)
    Z25524
    Consensus CDS
    CCDS28212.1
    UniProtKB/TrEMBL
    E5Q371
    Related
    ENSMUSP00000099853.5, ENSMUST00000084838.14
    Conserved Domains (2) summary
    pfam04549
    Location:163311
    CD47; CD47 transmembrane region
    pfam08204
    Location:20128
    V-set_CD47; CD47 immunoglobulin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    49671691..49732799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521809.5XP_006521872.1  leukocyte surface antigen CD47 isoform X1

    UniProtKB/TrEMBL
    E5Q371
    Conserved Domains (2) summary
    cd16090
    Location:26131
    IgV_CD47; Immunoglobulin variable domain (IgV) in CD47
    pfam04549
    Location:163311
    CD47; CD47 transmembrane region
  2. XM_006521810.5XP_006521873.1  leukocyte surface antigen CD47 isoform X2

    UniProtKB/TrEMBL
    E5Q371
    Conserved Domains (2) summary
    cd16090
    Location:26131
    IgV_CD47; Immunoglobulin variable domain (IgV) in CD47
    pfam04549
    Location:163311
    CD47; CD47 transmembrane region
  3. XM_030248985.2XP_030104845.1  leukocyte surface antigen CD47 isoform X4

    UniProtKB/TrEMBL
    E5Q371
    Conserved Domains (2) summary
    cd16090
    Location:26131
    IgV_CD47; Immunoglobulin variable domain (IgV) in CD47
    pfam04549
    Location:142290
    CD47; CD47 transmembrane region
  4. XM_030248984.2XP_030104844.1  leukocyte surface antigen CD47 isoform X3

    UniProtKB/TrEMBL
    E5Q371
    Related
    ENSMUSP00000154914.2, ENSMUST00000230281.2
    Conserved Domains (2) summary
    cd16090
    Location:26131
    IgV_CD47; Immunoglobulin variable domain (IgV) in CD47
    pfam04549
    Location:142290
    CD47; CD47 transmembrane region
  5. XM_030248986.2XP_030104846.1  leukocyte surface antigen CD47 isoform X5

    UniProtKB/TrEMBL
    E5Q371
    Conserved Domains (2) summary
    cd16090
    Location:26131
    IgV_CD47; Immunoglobulin variable domain (IgV) in CD47
    pfam04549
    Location:142290
    CD47; CD47 transmembrane region

RNA

  1. XR_003951763.2 RNA Sequence

  2. XR_003951762.2 RNA Sequence

  3. XR_384529.5 RNA Sequence

  4. XR_004939163.1 RNA Sequence