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Itgb7 integrin beta 7 [ Mus musculus (house mouse) ]

Gene ID: 16421, updated on 31-Jan-2019

Summary

Official Symbol
Itgb7provided by MGI
Official Full Name
integrin beta 7provided by MGI
Primary source
MGI:MGI:96616
See related
Ensembl:ENSMUSG00000001281
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly69
Expression
Biased expression in spleen adult (RPKM 26.7), mammary gland adult (RPKM 11.9) and 7 other tissues See more
Orthologs

Genomic context

See Itgb7 in Genome Data Viewer
Location:
15 F3; 15 57.39 cM
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (102215994..102233405, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (102046426..102062366, complement)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene sterol O-acyltransferase 2 Neighboring gene cysteine sulfinic acid decarboxylase Neighboring gene zinc finger protein 740 Neighboring gene retinoic acid receptor, gamma Neighboring gene predicted gene 9918

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
T cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
cell-matrix adhesion involved in ameboidal cell migration ISO
Inferred from Sequence Orthology
more info
 
heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
leukocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
 
receptor clustering ISO
Inferred from Sequence Orthology
more info
 
substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integrin alpha4-beta7 complex ISO
Inferred from Sequence Orthology
more info
 
integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
integrin beta-7
Names
M290 IEL antigen
integrin beta-P

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013566.2NP_038594.2  integrin beta-7 precursor

    See identical proteins and their annotated locations for NP_038594.2

    Status: VALIDATED

    Source sequence(s)
    AI322899, AK078871, AK155594
    Consensus CDS
    CCDS49740.1
    UniProtKB/Swiss-Prot
    P26011
    Related
    ENSMUSP00000001327.3, ENSMUST00000001327.10
    Conserved Domains (4) summary
    smart00187
    Location:50476
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:645716
    Integrin_B_tail; Integrin beta tail domain
    pfam07974
    Location:607635
    EGF_2; EGF-like domain
    pfam08725
    Location:749790
    Integrin_b_cyt; Integrin beta cytoplasmic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

    Range
    102215994..102233405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520482.2XP_006520545.1  integrin beta-7 isoform X1

    Conserved Domains (3) summary
    smart00187
    Location:50476
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:645716
    Integrin_B_tail; Integrin beta tail domain
    pfam07974
    Location:607635
    EGF_2; EGF-like domain
  2. XM_017316440.1XP_017171929.1  integrin beta-7 isoform X2

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