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Itgb7 integrin beta 7 [ Mus musculus (house mouse) ]

Gene ID: 16421, updated on 12-May-2024

Summary

Official Symbol
Itgb7provided by MGI
Official Full Name
integrin beta 7provided by MGI
Primary source
MGI:MGI:96616
See related
Ensembl:ENSMUSG00000001281 AllianceGenome:MGI:96616
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly69
Summary
Predicted to enable integrin binding activity. Acts upstream of or within T cell migration. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of integrin alpha4-beta7 complex. Predicted to be active in cell surface and focal adhesion. Is expressed in genitourinary system and thymus primordium. Orthologous to human ITGB7 (integrin subunit beta 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 26.7), mammary gland adult (RPKM 11.9) and 7 other tissues See more
Orthologs
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Genomic context

See Itgb7 in Genome Data Viewer
Location:
15 F2; 15 57.39 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (102124429..102141840, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102215994..102233405, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene sterol O-acyltransferase 2 Neighboring gene cysteine sulfinic acid decarboxylase Neighboring gene STARR-positive B cell enhancer ABC_E5519 Neighboring gene STARR-seq mESC enhancer starr_39822 Neighboring gene zinc finger protein 740 Neighboring gene STARR-positive B cell enhancer mm9_chr15:102055434-102055734 Neighboring gene STARR-positive B cell enhancer mm9_chr15:102055789-102056089 Neighboring gene STARR-seq mESC enhancer starr_39826 Neighboring gene STARR-seq mESC enhancer starr_39827 Neighboring gene retinoic acid receptor, gamma Neighboring gene STARR-seq mESC enhancer starr_39828 Neighboring gene predicted gene 9918

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-matrix adhesion involved in ameboidal cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte migration IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within leukocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of integrin alpha4-beta7 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
integrin beta-7
Names
M290 IEL antigen
integrin beta-P

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013566.2NP_038594.2  integrin beta-7 precursor

    See identical proteins and their annotated locations for NP_038594.2

    Status: VALIDATED

    Source sequence(s)
    AI322899, AK078871, AK155594
    Consensus CDS
    CCDS49740.1
    UniProtKB/Swiss-Prot
    P26011, Q3U2M1, Q64656
    Related
    ENSMUSP00000001327.4, ENSMUST00000001327.11
    Conserved Domains (4) summary
    smart00187
    Location:50476
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:645716
    Integrin_B_tail; Integrin beta tail domain
    pfam07974
    Location:607635
    EGF_2; EGF-like domain
    pfam08725
    Location:749790
    Integrin_b_cyt; Integrin beta cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    102124429..102141840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520482.2XP_006520545.1  integrin beta-7 isoform X1

    Conserved Domains (4) summary
    smart00187
    Location:50476
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07974
    Location:607635
    EGF_2; EGF-like domain
    pfam07965
    Location:645716
    Integrin_B_tail; Integrin beta tail domain
    pfam18372
    Location:480506
    I-EGF_1; Integrin beta epidermal growth factor like domain 1
  2. XM_017316440.1XP_017171929.1  integrin beta-7 isoform X2