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Itgb3 integrin beta 3 [ Mus musculus (house mouse) ]

Gene ID: 16416, updated on 29-Jan-2023

Summary

Official Symbol
Itgb3provided by MGI
Official Full Name
integrin beta 3provided by MGI
Primary source
MGI:MGI:96612
See related
Ensembl:ENSMUSG00000020689 AllianceGenome:MGI:96612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD61; GP3A; INGRB3
Summary
Enables integrin binding activity and protein kinase C binding activity. Involved in several processes, including positive regulation of T cell migration; positive regulation of osteoblast proliferation; and regulation of serotonin uptake. Acts upstream of or within several processes, including cellular response to platelet-derived growth factor stimulus; positive regulation of cell-substrate adhesion; and positive regulation of fibroblast migration. Located in several cellular components, including external side of plasma membrane; focal adhesion; and glutamatergic synapse. Part of alpha9-beta1 integrin-ADAM8 complex and alphav-beta3 integrin-PKCalpha complex. Is integral component of synaptic membrane. Is expressed in several structures, including bladder; dorsal aorta; gut; liver; and lung. Used to study Glanzmann's thrombasthenia and platelet-type bleeding disorder 16. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; blood platelet disease (multiple); end stage renal disease; and non-arteritic anterior ischemic optic neuropathy. Orthologous to human ITGB3 (integrin subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 21.3), ovary adult (RPKM 17.5) and 18 other tissues See more
Orthologs
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Genomic context

See Itgb3 in Genome Data Viewer
Location:
11 E1; 11 67.84 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (104498826..104561302)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (104608000..104670476)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene myosin, light polypeptide 4 Neighboring gene lin-52 DREAM MuvB core complex component, pseudogene Neighboring gene non-histone chromosomal protein HMG-14 pseudogene Neighboring gene ribosomal protein L3 pseudogene Neighboring gene EF-hand calcium binding domain 13

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC159221, MGC159223

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to C-X3-C chemokine binding ISO
Inferred from Sequence Orthology
more info
 
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables extracellular matrix binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to fibrinogen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to fibrinogen binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables fibronectin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to insulin-like growth factor I binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to neuregulin binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein disulfide isomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase C binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables vascular endothelial growth factor receptor 2 binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in apolipoprotein A-I-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic cell clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in apoptotic cell clearance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood coagulation, fibrin clot formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell projection morphogenesis IC
Inferred by Curator
more info
PubMed 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell-matrix adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell-substrate junction assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to platelet-derived growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in maintenance of postsynaptic specialization structure ISO
Inferred from Sequence Orthology
more info
 
involved_in negative chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of low-density lipoprotein receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in platelet activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone resorption IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glomerular mesangial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of osteoclast differentiation IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of serotonin uptake IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of trophoblast cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of alpha9-beta1 integrin-ADAM8 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of alphav-beta3 integrin-HMGB1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of alphav-beta3 integrin-IGF-1-IGF1R complex ISO
Inferred from Sequence Orthology
more info
 
part_of alphav-beta3 integrin-PKCalpha complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of alphav-beta3 integrin-PKCalpha complex ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in filopodium membrane ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in glycinergic synapse ISO
Inferred from Sequence Orthology
more info
 
part_of integrin alpha9-beta1 complex TAS
Traceable Author Statement
more info
PubMed 
part_of integrin alphav-beta3 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of integrin complex ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium membrane ISO
Inferred from Sequence Orthology
more info
 
located_in melanosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic membrane IEP
Inferred from Expression Pattern
more info
PubMed 

General protein information

Preferred Names
integrin beta-3
Names
GPIIIa
platelet glycoprotein IIIa (GP3A)
platelet gpIIIa
platelet membrane glycoprotein IIIa

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016780.2NP_058060.2  integrin beta-3 precursor

    See identical proteins and their annotated locations for NP_058060.2

    Status: VALIDATED

    Source sequence(s)
    BC125520, BQ033439, BX000996
    Consensus CDS
    CCDS25536.1
    UniProtKB/Swiss-Prot
    O54890, Q3TZC6
    Related
    ENSMUSP00000021028.5, ENSMUST00000021028.5
    Conserved Domains (3) summary
    pfam00362
    Location:37460
    Integrin_beta; Integrin, beta chain
    pfam07965
    Location:633716
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:743785
    Integrin_b_cyt; Integrin beta cytoplasmic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    104498826..104561302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532312.4XP_006532375.1  integrin beta-3 isoform X1

    Conserved Domains (4) summary
    smart00187
    Location:18441
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07965
    Location:614697
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:724766
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:443472
    I-EGF_1; Integrin beta epidermal growth factor like domain 1