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Itgav integrin alpha V [ Mus musculus (house mouse) ]

Gene ID: 16410, updated on 8-Feb-2024

Summary

Official Symbol
Itgavprovided by MGI
Official Full Name
integrin alpha Vprovided by MGI
Primary source
MGI:MGI:96608
See related
Ensembl:ENSMUSG00000027087 AllianceGenome:MGI:96608
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD51; 1110004F14Rik; 2610028E01Rik; D430040G12Rik
Summary
This gene encodes a protein that is a member of the integrin superfamily. Integrins are transmembrane receptors involved cell adhesion and signaling, and they are subdivided based on the heterodimer formation of alpha and beta chains. This protein has been shown to heterodimerize with beta 1, beta 3, beta 6 and beta 8. The heterodimer of alpha v and beta 3 forms the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. In mouse, deficiency of this gene is associated with defects in vascular morphogenesis in the brain and early post-natal death. [provided by RefSeq, May 2013]
Expression
Ubiquitous expression in placenta adult (RPKM 13.0), ovary adult (RPKM 12.9) and 27 other tissues See more
Orthologs
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Genomic context

See Itgav in Genome Data Viewer
Location:
2 D; 2 49.33 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (83554796..83637261)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (83722303..83806917)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 54, member A pseudogene Neighboring gene STARR-seq mESC enhancer starr_04984 Neighboring gene STARR-seq mESC enhancer starr_04985 Neighboring gene STARR-positive B cell enhancer ABC_E11141 Neighboring gene STARR-positive B cell enhancer ABC_E11142 Neighboring gene STARR-positive B cell enhancer ABC_E7831 Neighboring gene STARR-positive B cell enhancer mm9_chr2:83505584-83505885 Neighboring gene zinc finger CCCH-type containing 15 Neighboring gene STARR-seq mESC enhancer starr_04989 Neighboring gene DNA methyltransferase 3-like, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E2039 Neighboring gene STARR-positive B cell enhancer ABC_E7832 Neighboring gene family with sequence similarity 171, member B Neighboring gene STARR-positive B cell enhancer ABC_E11143 Neighboring gene zinc finger SWIM-type containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to C-X3-C chemokine binding ISO
Inferred from Sequence Orthology
more info
 
enables extracellular matrix binding ISO
Inferred from Sequence Orthology
more info
 
enables extracellular matrix protein binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to insulin-like growth factor I binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to neuregulin binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to opsonin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to protein kinase C binding IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in T cell activation TAS
Traceable Author Statement
more info
PubMed 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in apolipoprotein A-I-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in apoptotic cell clearance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in apoptotic cell clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic cell clearance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-matrix adhesion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cell-matrix adhesion TAS
Traceable Author Statement
more info
PubMed 
involved_in cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of molecule of bacterial origin TAS
Traceable Author Statement
more info
PubMed 
involved_in endodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in endothelial cell migration TAS
Traceable Author Statement
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fertilization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in focal adhesion assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in gonad morphogenesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of entry of bacterium into host cell ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipid transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipoprotein metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of low-density lipoprotein receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of small GTPase mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of bone resorption TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of phagocytosis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of transforming growth factor beta activation ISO
Inferred from Sequence Orthology
more info
 
involved_in release of sequestered calcium ion into cytosol TAS
Traceable Author Statement
more info
PubMed 
involved_in response to nitric oxide TAS
Traceable Author Statement
more info
PubMed 
involved_in substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in symbiont entry into host cell ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in trophoblast giant cell differentiation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of alphav-beta3 integrin-HMGB1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of alphav-beta3 integrin-IGF-1-IGF1R complex ISO
Inferred from Sequence Orthology
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in filopodium membrane ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of integrin alphav-beta1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin alphav-beta3 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin alphav-beta3 complex TAS
Traceable Author Statement
more info
PubMed 
part_of integrin alphav-beta5 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of integrin alphav-beta5 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin alphav-beta6 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of integrin alphav-beta6 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin alphav-beta8 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of integrin complex ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in microvillus membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
integrin alpha-V
Names
alpha v integrin
vitronectin receptor alpha polypeptide (VNRA)
vitronectin receptor subunit alpha

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398691.1NP_001385620.1  integrin alpha-V isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL772301
    UniProtKB/TrEMBL
    A0A0F7IQ06
    Conserved Domains (4) summary
    smart00191
    Location:366420
    Int_alpha; Integrin alpha (beta-propellor repeats)
    sd00039
    Location:125182
    7WD40; WD40 repeat [structural motif]
    pfam08441
    Location:466909
    Integrin_alpha2; Integrin alpha
    pfam13517
    Location:220270
    VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella
  2. NM_008402.4NP_032428.2  integrin alpha-V isoform 1 precursor

    See identical proteins and their annotated locations for NP_032428.2

    Status: REVIEWED

    Source sequence(s)
    AL772301
    Consensus CDS
    CCDS16181.1
    UniProtKB/Swiss-Prot
    A2AKI6, P43406
    UniProtKB/TrEMBL
    A0A0F7IQ06
    Related
    ENSMUSP00000028499.5, ENSMUST00000028499.11
    Conserved Domains (3) summary
    smart00191
    Location:367421
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:467910
    Integrin_alpha2; Integrin alpha
    sd00039
    Location:126183
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    83554796..83637261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)