PAQR7 progestin and adipoQ receptor family member 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PAQR7provided by HGNC
Official Full Name: progestin and adipoQ receptor family member 7provided by HGNC
Primary source: HGNC:HGNC:23146
See related: Ensembl:ENSG00000182749 MIM:607779
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: mSR; MPRA; PGLP
Expression: Broad expression in kidney (RPKM 22.0), testis (RPKM 21.9) and 22 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 1p36.11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
109.20200522	current	GRCh38.p13 (GCF_000001405.39)	1	NC_000001.11 (25861484..25876707, complement)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (26187975..26202461, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results suggest that progesterone induces vascular smooth muscle cell relaxation by reducing cellular calcium levels through mPRalpha-induced alterations in multiple signaling pathways.
Title: Role of mPRα (PAQR7) in progesterone-induced Ca2+ decrease in human vascular smooth muscle cells.
Utilizing both genetic and pharmacologic approaches, the authors establish that sex steroid effects on human melanin synthesis are mediated by the membrane-bound, steroid hormone receptors G protein-coupled estrogen receptor (GPER), and progestin and adipoQ receptor 7 (PAQR7).
Title: Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors.
The effects of progesterone treatment on the expression levels of progesterone receptor membrane component 1 (PGRMC1), plasminogen activator inhibitor 1 RNA-binding protein (PAIRBP1), and progestin and adipoQ receptor 7 (PAQR7) on both mRNA and protein levels were investigated in spheroids derived from human glioma cell lines U-87 MG and LN-229.
Title: Expression of Progesterone Receptor Membrane Component 1 (PGRMC1), Progestin and AdipoQ Receptor 7 (PAQPR7), and Plasminogen Activator Inhibitor 1 RNA-Binding Protein (PAIRBP1) in Glioma Spheroids In Vitro.
Data show abundant mPRalpha (PAQR7), mPRbeta (PAQR8), and mPRgamma (PAQR5), but not classical nuclear PR (A or B isoforms) mRNA expression and mPRalpha protein expression in a panel of commonly used ovarian cancer cell lines.
Title: Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events.
mPRalpha is an intermediary in progestin stimulation of sperm motility in humans by a mechanism involving G-protein activation
Title: Progestin functions in vertebrate gametes mediated by membrane progestin receptors (mPRs): Identification of mPRalpha on human sperm and its association with sperm motility.
Heterologous expression of MPRA in yeast confirms its ability to function as a membrane progesterone receptor.
Title: Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in yeast confirms their ability to function as membrane progesterone receptors.
cDNAs for the mPR alpha subtypes from spotted seatrout (st-mPRalpha) and humans (hu-mPRalpha) encode progestin receptors that display many functional characteristics of G protein-coupled receptors.
Title: Steroid and G protein binding characteristics of the seatrout and human progestin membrane receptor alpha subtypes and their evolutionary origins.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

D15S1477 (e-PCR)
- UniSTS:474482

D1S1425 (e-PCR)
- UniSTS:149621

G35510 (e-PCR)
- UniSTS:44150

Homology

Homologs of the PAQR7 gene: The PAQR7 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Orthologs from Annotation Pipeline: 236 organisms have orthologs with human gene PAQR7
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
steroid binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
steroid hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
multicellular organism development	IEA Inferred from Electronic Annotation more info
oogenesis	IEA Inferred from Electronic Annotation more info
response to steroid hormone	IBA Inferred from Biological aspect of Ancestor more info	PubMed
steroid hormone mediated signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
integral component of membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: membrane progestin receptor alpha

Names: 2310021M12Rik; mPR alpha; membrane progesterone P4 receptor alpha; membrane progesterone receptor alpha; progesterone and adipoQ receptor family member 7; progestin and adipoQ receptor family member VII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178422.6 → NP_848509.1 membrane progestin receptor alpha

See identical proteins and their annotated locations for NP_848509.1

Status: VALIDATED

Source sequence(s)

AL033528

Consensus CDS

CCDS267.1

UniProtKB/Swiss-Prot

Q86WK9

Conserved Domains (1) summary

pfam03006
Location:66 → 290

HlyIII; Haemolysin-III related