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PAQR7 progestin and adipoQ receptor family member 7 [ Homo sapiens (human) ]

Gene ID: 164091, updated on 17-Sep-2024

Summary

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Official Symbol
PAQR7provided by HGNC
Official Full Name
progestin and adipoQ receptor family member 7provided by HGNC
Primary source
HGNC:HGNC:23146
See related
Ensembl:ENSG00000182749 MIM:607779; AllianceGenome:HGNC:23146
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mSR; MPRA; PGLP
Summary
Predicted to enable steroid binding activity and steroid hormone receptor activity. Predicted to be involved in response to steroid hormone. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney (RPKM 22.0), testis (RPKM 21.9) and 22 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
1p36.11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (25861484..25875708, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (25698915..25713139, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26187975..26202199, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 467 Neighboring gene uncharacterized LOC646471 Neighboring gene mitochondrial fission regulator 1 like Neighboring gene aurora kinase A and ninein interacting protein Neighboring gene hESC enhancers GRCh37_chr1:26185603-26186228 and GRCh37_chr1:26186229-26186854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26189139-26189908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26196207-26196708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 470 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26201379-26201878 Neighboring gene stathmin 1 Neighboring gene small nuclear ribonucleoprotein polypeptide F pseudogene 2 Neighboring gene ribosomal protein L39 pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Progesterone exerts a neuroprotective action in a Parkinson's disease human cell model through membrane progesterone receptor α (mPRα/PAQR7). Castelnovo LF, et al. Front Endocrinol (Lausanne), 2023. PMID 36967764, Free PMC Article
  2. Membrane Progesterone Receptor α (mPRα/PAQR7) Promotes Survival and Neurite Outgrowth of Human Neuronal Cells by a Direct Action and Through Schwann Cell-like Stem Cells. Castelnovo LF, et al. J Mol Neurosci, 2022 Oct. PMID 35974286
  3. Establishment of a steroid binding assay for membrane progesterone receptor alpha (PAQR7) by using graphene quantum dots (GQDs). Jyoti MMS, et al. Biochem Biophys Res Commun, 2022 Feb 12. PMID 35007844
  4. Role of mPRα (PAQR7) in progesterone-induced Ca2+ decrease in human vascular smooth muscle cells. Pang Y, et al. J Mol Endocrinol, 2019 Oct. PMID 31416049
  5. Progestin functions in vertebrate gametes mediated by membrane progestin receptors (mPRs): Identification of mPRalpha on human sperm and its association with sperm motility. Thomas P, et al. Steroids, 2009 Jul. PMID 19071147

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice.
    Title: Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice.
  2. Membrane progesterone receptors on the cell membrane: A review highlighting potential export motifs in mPRalpha regulating its trafficking to the cell surface.
    Title: Membrane progesterone receptors on the cell membrane: A review highlighting potential export motifs in mPRα regulating its trafficking to the cell surface.
  3. Progesterone exerts a neuroprotective action in a Parkinson's disease human cell model through membrane progesterone receptor alpha (mPRalpha/PAQR7).
    Title: Progesterone exerts a neuroprotective action in a Parkinson's disease human cell model through membrane progesterone receptor α (mPRα/PAQR7).
  4. Membrane Progesterone Receptor alpha (mPRalpha/PAQR7) Promotes Survival and Neurite Outgrowth of Human Neuronal Cells by a Direct Action and Through Schwann Cell-like Stem Cells.
    Title: Membrane Progesterone Receptor α (mPRα/PAQR7) Promotes Survival and Neurite Outgrowth of Human Neuronal Cells by a Direct Action and Through Schwann Cell-like Stem Cells.
  5. Establishment of a steroid binding assay for membrane progesterone receptor alpha (PAQR7) by using graphene quantum dots (GQDs).
    Title: Establishment of a steroid binding assay for membrane progesterone receptor alpha (PAQR7) by using graphene quantum dots (GQDs).
  6. Membrane progesterone receptor alpha (mPRalpha/PAQR7) promotes migration, proliferation and BDNF release in human Schwann cell-like differentiated adipose stem cells.
    Title: Membrane progesterone receptor α (mPRα/PAQR7) promotes migration, proliferation and BDNF release in human Schwann cell-like differentiated adipose stem cells.
  7. The results suggest that progesterone induces vascular smooth muscle cell relaxation by reducing cellular calcium levels through mPRalpha-induced alterations in multiple signaling pathways.
    Title: Role of mPRα (PAQR7) in progesterone-induced Ca2+ decrease in human vascular smooth muscle cells.
  8. Utilizing both genetic and pharmacologic approaches, the authors establish that sex steroid effects on human melanin synthesis are mediated by the membrane-bound, steroid hormone receptors G protein-coupled estrogen receptor (GPER), and progestin and adipoQ receptor 7 (PAQR7).
    Title: Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors.
  9. The effects of progesterone treatment on the expression levels of progesterone receptor membrane component 1 (PGRMC1), plasminogen activator inhibitor 1 RNA-binding protein (PAIRBP1), and progestin and adipoQ receptor 7 (PAQR7) on both mRNA and protein levels were investigated in spheroids derived from human glioma cell lines U-87 MG and LN-229.
    Title: Expression of Progesterone Receptor Membrane Component 1 (PGRMC1), Progestin and AdipoQ Receptor 7 (PAQPR7), and Plasminogen Activator Inhibitor 1 RNA-Binding Protein (PAIRBP1) in Glioma Spheroids In Vitro.
  10. Data show abundant mPRalpha (PAQR7), mPRbeta (PAQR8), and mPRgamma (PAQR5), but not classical nuclear PR (A or B isoforms) mRNA expression and mPRalpha protein expression in a panel of commonly used ovarian cancer cell lines.
    Title: Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nuclear steroid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables steroid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in oogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in response to steroid hormone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in steroid hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
membrane progestin receptor alpha
Names
2310021M12Rik
mPR alpha
membrane progesterone P4 receptor alpha
membrane progesterone receptor alpha
progesterone and adipoQ receptor family member 7
progestin and adipoQ receptor family member VII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178422.6 → NP_848509.1  membrane progestin receptor alpha

    See identical proteins and their annotated locations for NP_848509.1

    Status: VALIDATED

    Source sequence(s)
    AL033528
    Consensus CDS
    CCDS267.1
    UniProtKB/Swiss-Prot
    A2A2D3, Q5XKF9, Q86VE4, Q86WK9
    Related
    ENSP00000502514.1, ENST00000675840.1
    Conserved Domains (1) summary
    pfam03006
    Location:66 → 290
    HlyIII; Haemolysin-III related

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    25861484..25875708 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245746.4 → XP_005245803.1  membrane progestin receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_005245803.1

    UniProtKB/Swiss-Prot
    A2A2D3, Q5XKF9, Q86VE4, Q86WK9
    Conserved Domains (1) summary
    pfam03006
    Location:66 → 290
    HlyIII; Haemolysin-III related

  2. XM_011540862.3 → XP_011539164.1  membrane progestin receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_011539164.1

    UniProtKB/Swiss-Prot
    A2A2D3, Q5XKF9, Q86VE4, Q86WK9
    Conserved Domains (1) summary
    pfam03006
    Location:66 → 290
    HlyIII; Haemolysin-III related

  3. XM_047447964.1 → XP_047303920.1  membrane progestin receptor alpha isoform X1

    UniProtKB/Swiss-Prot
    A2A2D3, Q5XKF9, Q86VE4, Q86WK9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    25698915..25713139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334782.1 → XP_054190757.1  membrane progestin receptor alpha isoform X1

    UniProtKB/Swiss-Prot
    A2A2D3, Q5XKF9, Q86VE4, Q86WK9

  2. XM_054334783.1 → XP_054190758.1  membrane progestin receptor alpha isoform X1

    UniProtKB/Swiss-Prot
    A2A2D3, Q5XKF9, Q86VE4, Q86WK9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86WK9.1 GenPept UniProtKB/Swiss-Prot:Q86WK9

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