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Itgal integrin alpha L [ Mus musculus (house mouse) ]

Gene ID: 16408, updated on 8-Feb-2024

Summary

Official Symbol
Itgalprovided by MGI
Official Full Name
integrin alpha Lprovided by MGI
Primary source
MGI:MGI:96606
See related
Ensembl:ENSMUSG00000030830 AllianceGenome:MGI:96606
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cd11a; LFA-1; Ly-15; Ly-21; (p180); LFA-1A
Summary
Predicted to enable ICAM-3 receptor activity and cell adhesion molecule binding activity. Involved in cell-cell adhesion. Acts upstream of or within several processes, including activated T cell proliferation; positive regulation of T cell proliferation; and positive regulation of calcium-mediated signaling. Located in cell-cell junction; external side of plasma membrane; and immunological synapse. Is expressed in heart; hemolymphoid system; and vault of skull. Orthologous to human ITGAL (integrin subunit alpha L). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 94.8), spleen adult (RPKM 38.1) and 2 other tissues See more
Orthologs
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Genomic context

See Itgal in Genome Data Viewer
Location:
7 F3; 7 69.44 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126895404..126934309)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127296139..127335137)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene selenophosphate synthetase 2 Neighboring gene STARR-positive B cell enhancer ABC_E6606 Neighboring gene ribosomal protein, large, P1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134439631-134439814 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134439816-134439925 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134452009-134452210 Neighboring gene STARR-positive B cell enhancer ABC_E9709 Neighboring gene STARR-positive B cell enhancer ABC_E11368 Neighboring gene zinc finger protein 768 Neighboring gene ferredoxin 1-like pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ICAM-3 receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within leukocyte cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in memory T cell extravasation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phagocytosis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor clustering ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
part_of integrin alphaL-beta2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
integrin alpha-L
Names
CD11 antigen-like family member A
alpha L integrin
leukocyte adhesion glycoprotein LFA-1 alpha chain
leukocyte function-associated molecule 1 alpha chain
lymphocyte antigen 15
lymphocyte function associated antigen 1, alpha polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253872.1NP_001240801.1  integrin alpha-L isoform 1 precursor

    See identical proteins and their annotated locations for NP_001240801.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC133494
    Consensus CDS
    CCDS57589.1
    UniProtKB/Swiss-Prot
    E9Q5M7, E9QNL8, P24063, Q3U159
    UniProtKB/TrEMBL
    Q9WTV4
    Related
    ENSMUSP00000101913.3, ENSMUST00000106306.9
    Conserved Domains (2) summary
    smart00191
    Location:515567
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cl00057
    Location:152321
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  2. NM_001253873.1NP_001240802.1  integrin alpha-L isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC133494, AK171389
    Consensus CDS
    CCDS57588.1
    UniProtKB/TrEMBL
    Q9WTV4
    Related
    ENSMUSP00000113946.2, ENSMUST00000117762.8
    Conserved Domains (3) summary
    smart00191
    Location:515567
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:610997
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:152321
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  3. NM_001253874.1NP_001240803.1  integrin alpha-L isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AC133494
    UniProtKB/TrEMBL
    B7ZN91
    Conserved Domains (3) summary
    smart00191
    Location:515567
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:610998
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:152321
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  4. NM_008400.3NP_032426.2  integrin alpha-L isoform 2 precursor

    See identical proteins and their annotated locations for NP_032426.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an two alternate in-frame splice sites in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC133494, BC145096
    UniProtKB/TrEMBL
    B7ZN92, Q9WTV4
    Conserved Domains (3) summary
    smart00191
    Location:515567
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:610997
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:152321
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126895404..126934309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507393.5XP_006507456.1  integrin alpha-L isoform X1

    Conserved Domains (3) summary
    smart00191
    Location:515567
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:610740
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:152321
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...