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Itga4 integrin alpha 4 [ Mus musculus (house mouse) ]

Gene ID: 16401, updated on 8-Dec-2022

Summary

Official Symbol
Itga4provided by MGI
Official Full Name
integrin alpha 4provided by MGI
Primary source
MGI:MGI:96603
See related
Ensembl:ENSMUSG00000027009 AllianceGenome:MGI:96603
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD49D; Itga4B
Summary
Enables fibronectin binding activity. Acts upstream of or within several processes, including chorio-allantoic fusion; face development; and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in cell-cell junction and external side of plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; embryo mesenchyme; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in autism spectrum disorder and pancreatic cancer. Orthologous to human ITGA4 (integrin subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 10.1), liver E14.5 (RPKM 9.6) and 17 other tissues See more
Orthologs
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Genomic context

See Itga4 in Genome Data Viewer
Location:
2 C3; 2 47.38 cM
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (79084767..79163458)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (79255426..79333114)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene heat shock protein 1 (chaperonin) pseudogene 14 Neighboring gene predicted gene, 39866 Neighboring gene predicted gene, 35813 Neighboring gene ceramide kinase-like Neighboring gene predicted gene, 22606 Neighboring gene tubulin, beta 6 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to C-X3-C chemokine binding ISO
Inferred from Sequence Orthology
more info
 
enables antigen binding ISO
Inferred from Sequence Orthology
more info
 
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables fibronectin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein antigen binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonogenesis involved in innervation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell adhesion TAS
Traceable Author Statement
more info
PubMed 
involved_in cell-cell adhesion in response to extracellular stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-matrix adhesion TAS
Traceable Author Statement
more info
PubMed 
involved_in cell-matrix adhesion involved in ameboidal cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chorio-allantoic fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in clathrin-dependent extracellular exosome endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in diapedesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within face development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in import into cell ISO
Inferred from Sequence Orthology
more info
 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
 
involved_in mesenchyme development TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection extension ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pericyte cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vascular associated smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in visceral serous pericardium development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface TAS
Traceable Author Statement
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
part_of integrin alpha4-beta7 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
integrin alpha-4
Names
CD49 antigen-like family member D
LPAM subunit alpha
VLA-4 receptor, alpha 4 subunit
VLA-4 subunit alpha
integrin alpha-IV
integrin alpha4B
lymphocyte Peyer patch adhesion molecules subunit alpha

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010576.4NP_034706.3  integrin alpha-4 precursor

    See identical proteins and their annotated locations for NP_034706.3

    Status: VALIDATED

    Source sequence(s)
    AL844590
    Consensus CDS
    CCDS16168.1
    UniProtKB/Swiss-Prot
    Q00651
    UniProtKB/TrEMBL
    Q792F9, Q8BQ25
    Related
    ENSMUSP00000099718.4, ENSMUST00000099972.5
    Conserved Domains (2) summary
    smart00191
    Location:366418
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:463902
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    79084767..79163458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158647.1XP_036014540.1  integrin alpha-4 isoform X1

    Conserved Domains (2) summary
    smart00191
    Location:366418
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:463565
    Integrin_alpha2; Integrin alpha