U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Itga2b integrin alpha 2b [ Mus musculus (house mouse) ]

Gene ID: 16399, updated on 27-Nov-2024

Summary

Official Symbol
Itga2bprovided by MGI
Official Full Name
integrin alpha 2bprovided by MGI
Primary source
MGI:MGI:96601
See related
Ensembl:ENSMUSG00000034664 AllianceGenome:MGI:96601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD41; CD41B; GpIIb; alphaIIb
Summary
Enables extracellular matrix binding activity. Acts upstream of or within cell-matrix adhesion. Located in external side of plasma membrane and focal adhesion. Is expressed in several structures, including early conceptus; hematopoietic system; liver; mesenchyme derived from splanchnopleure; and umbilical blood vessel. Used to study platelet-type bleeding disorder 16. Human ortholog(s) of this gene implicated in Glanzmann's thrombasthenia; platelet-type bleeding disorder 16; thrombocytopenia; and von Willebrand's disease 1. Orthologous to human ITGA2B (integrin subunit alpha 2b). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in spleen adult (RPKM 19.1), liver E14.5 (RPKM 14.7) and 16 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Itga2b in Genome Data Viewer
Location:
11 D; 11 66.29 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102344134..102360570, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102453297..102469883, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancers ABC_E9375 and ABC_E8457 Neighboring gene family with sequence similarity 171, member A2 Neighboring gene granulin Neighboring gene STARR-positive B cell enhancer ABC_E7070 Neighboring gene G patch domain containing 8 Neighboring gene cytochrome b-c1 complex subunit 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30811 Neighboring gene midkine pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables fibrinogen binding IEA
Inferred from Electronic Annotation
more info
 
enables fibrinogen binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-matrix adhesion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in integrin-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of leukocyte migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
part_of integrin alphaIIb-beta3 complex ISO
Inferred from Sequence Orthology
more info
 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
integrin alpha-IIb
Names
GP IIb
GPalpha IIb
alpha IIb
platelet glycoprotein IIb of IIb/II Ia complex
platelet membrane glycoprotein IIb

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010575.3NP_034705.2  integrin alpha-IIb precursor

    See identical proteins and their annotated locations for NP_034705.2

    Status: VALIDATED

    Source sequence(s)
    AL596258
    Consensus CDS
    CCDS25500.1
    UniProtKB/Swiss-Prot
    Q3U3R7, Q64229, Q9QUM0, Q9Z2M0
    UniProtKB/TrEMBL
    B2RPR7
    Related
    ENSMUSP00000099375.4, ENSMUST00000103086.4
    Conserved Domains (2) summary
    smart00191
    Location:383437
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:480916
    Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    102344134..102360570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)