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SDE2 SDE2 telomere maintenance homolog [ Homo sapiens (human) ]

Gene ID: 163859, updated on 23-Nov-2021

Summary

Official Symbol
SDE2provided by HGNC
Official Full Name
SDE2 telomere maintenance homologprovided by HGNC
Primary source
HGNC:HGNC:26643
See related
Ensembl:ENSG00000143751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1orf55; dJ671D7.1
Expression
Ubiquitous expression in bone marrow (RPKM 11.6), thyroid (RPKM 7.7) and 25 other tissues See more
Orthologs
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Genomic context

See SDE2 in Genome Data Viewer
Location:
1q42.12
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (225982702..225999343, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (226170403..226187044, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene left-right determination factor 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 3 Neighboring gene H3.3 histone A Neighboring gene long intergenic non-protein coding RNA 1703

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35382

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables damaged DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitotic G1 DNA damage checkpoint signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
replication stress response regulator SDE2
Names
UPF0667 protein C1orf55
protein SDE2 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152608.4NP_689821.3  replication stress response regulator SDE2

    See identical proteins and their annotated locations for NP_689821.3

    Status: VALIDATED

    Source sequence(s)
    AL133288, BC016290, CB140971
    Consensus CDS
    CCDS41473.1
    UniProtKB/Swiss-Prot
    Q6IQ49
    Related
    ENSP00000272091.7, ENST00000272091.8
    Conserved Domains (2) summary
    pfam13297
    Location:385444
    Telomere_Sde2_2; Telomere stability C-terminal
    cl00155
    Location:69144
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    225982702..225999343 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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