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SPRR4 small proline rich protein 4 [ Homo sapiens (human) ]

Gene ID: 163778, updated on 5-Aug-2022

Summary

Official Symbol
SPRR4provided by HGNC
Official Full Name
small proline rich protein 4provided by HGNC
Primary source
HGNC:HGNC:23173
See related
Ensembl:ENSG00000184148 MIM:616363; AllianceGenome:HGNC:23173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in keratinization. Predicted to be located in cell cortex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in skin (RPKM 6.2) and testis (RPKM 1.2) See more
Orthologs
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Genomic context

See SPRR4 in Genome Data Viewer
Location:
1q21.3
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (152968750..152972574)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152107318..152109240)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152943124..152945050)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene IVL promoter region Neighboring gene involucrin Neighboring gene long intergenic non-protein coding RNA 1527 Neighboring gene small proline rich protein 5 Neighboring gene small proline rich protein 1A Neighboring gene small proline rich protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138375, MGC138377

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in keratinization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
small proline-rich protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173080.3NP_775103.1  small proline-rich protein 4

    See identical proteins and their annotated locations for NP_775103.1

    Status: VALIDATED

    Source sequence(s)
    AI125483, AL356867, BC112170, W77994
    Consensus CDS
    CCDS1031.1
    UniProtKB/Swiss-Prot
    Q5T522, Q96PI1
    Related
    ENSP00000332163.2, ENST00000328051.3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    152968750..152972574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000482.3XP_016855971.1  small proline-rich protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q5T522, Q96PI1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    152107318..152109240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)