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CITED4 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 [ Homo sapiens (human) ]

Gene ID: 163732, updated on 1-Jun-2020

Summary

Official Symbol
CITED4provided by HGNC
Official Full Name
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4provided by HGNC
Primary source
HGNC:HGNC:18696
See related
Ensembl:ENSG00000179862 MIM:606815
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors. [provided by RefSeq, Aug 2011]
Orthologs

Genomic context

See CITED4 in Genome Data Viewer
Location:
1p34.2; 1p35-p34
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (40861054..40862363, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (41326728..41328018, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily Q member 4 Neighboring gene GATA motif-containing MPRA enhancers 242 and 247 Neighboring gene uncharacterized LOC105378676 Neighboring gene protein phosphatase 2 catalytic subunit alpha pseudogene Neighboring gene ubiquitin conjugating enzyme E2 V1 pseudogene 8

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
positive regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
response to estrogen ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cbp/p300-interacting transactivator 4
Names
MRG-2
MSG1-related protein 2
transcriptional co-activator 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133467.3NP_597724.1  cbp/p300-interacting transactivator 4

    See identical proteins and their annotated locations for NP_597724.1

    Status: VALIDATED

    Source sequence(s)
    AC119677, BC052559
    Consensus CDS
    CCDS458.1
    UniProtKB/Swiss-Prot
    Q96RK1
    Related
    ENSP00000361721.2, ENST00000372638.4
    Conserved Domains (1) summary
    pfam04487
    Location:1184
    CITED; CITED

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    40861054..40862363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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