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CALML6 calmodulin like 6 [ Homo sapiens (human) ]

Gene ID: 163688, updated on 5-Jan-2022

Summary

Official Symbol
CALML6provided by HGNC
Official Full Name
calmodulin like 6provided by HGNC
Primary source
HGNC:HGNC:24193
See related
Ensembl:ENSG00000169885 MIM:610171
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAGLP
Summary
Predicted to enable calcium ion binding activity and enzyme regulator activity. Predicted to be involved in regulation of catalytic activity. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See CALML6 in Genome Data Viewer
Location:
1p36.33
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (1913751..1917296)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1846699..1848735)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene G protein subunit beta 1 Neighboring gene Sharpr-MPRA regulatory region 3728 Neighboring gene GNB1 divergent transcript Neighboring gene transmembrane protein 52 Neighboring gene cilia and flagella associated protein 74 Neighboring gene uncharacterized LOC107984872

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calmodulin-like protein 6
Names
EF-hand protein
calglandulin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330313.2NP_001317242.1  calmodulin-like protein 6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL109917
    Consensus CDS
    CCDS81255.1
    UniProtKB/TrEMBL
    B1AKR1
    Related
    ENSP00000367867.3, ENST00000378604.3
  2. NM_138705.4NP_619650.2  calmodulin-like protein 6 isoform 1

    See identical proteins and their annotated locations for NP_619650.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF490905, AL109917
    Consensus CDS
    CCDS30566.1
    UniProtKB/Swiss-Prot
    Q8TD86
    Related
    ENSP00000304643.3, ENST00000307786.8
    Conserved Domains (2) summary
    PTZ00184
    Location:26173
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:111173
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    1913751..1917296
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005244729.3XP_005244786.2  calmodulin-like protein 6 isoform X1

    Conserved Domains (2) summary
    PTZ00184
    Location:48195
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:133195
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
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