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DCTD dCMP deaminase [ Homo sapiens (human) ]

Gene ID: 1635, updated on 7-Jun-2020

Summary

Official Symbol
DCTDprovided by HGNC
Official Full Name
dCMP deaminaseprovided by HGNC
Primary source
HGNC:HGNC:2710
See related
Ensembl:ENSG00000129187 MIM:607638
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 37.0), adrenal (RPKM 19.8) and 25 other tissues See more
Orthologs

Genomic context

See DCTD in Genome Data Viewer
Location:
4q35.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (182890091..182917477, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (183811244..183838630, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene chr4 t(4;18)(q35;q18) HERV-H recombination region Neighboring gene uncharacterized LOC105377576 Neighboring gene uncharacterized LOC105377577 Neighboring gene uncharacterized LOC107986327

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111062

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dCMP deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
dTMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dUMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleobase-containing small molecule interconversion TAS
Traceable Author Statement
more info
 
pyrimidine nucleotide metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
deoxycytidylate deaminase
NP_001012750.1
NP_001338672.1
NP_001338673.1
NP_001338674.1
NP_001338676.1
NP_001338677.1
NP_001338679.1
NP_001338682.1
NP_001912.2
XP_005262835.1
XP_005262838.1
XP_005262839.1
XP_006714178.1
XP_006714179.1
XP_011529976.1
XP_011529977.1
XP_011529978.1
XP_016863309.1
XP_016863311.1
XP_016863312.1
XP_016863313.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012732.1NP_001012750.1  deoxycytidylate deaminase isoform a

    See identical proteins and their annotated locations for NP_001012750.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC079766, BI544680, BQ228061, BU188090
    Consensus CDS
    CCDS34108.1
    UniProtKB/Swiss-Prot
    P32321
    Related
    ENSP00000349576.3, ENST00000357067.7
    Conserved Domains (1) summary
    cd01286
    Location:28149
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  2. NM_001351743.1NP_001338672.1  deoxycytidylate deaminase isoform b

    Status: REVIEWED

    Source sequence(s)
    AC079766, AK310788, AL539949, BC088357, BM970269, L12136
    Consensus CDS
    CCDS3831.1
    Conserved Domains (1) summary
    cd01286
    Location:17138
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  3. NM_001351744.1NP_001338673.1  deoxycytidylate deaminase isoform b

    Status: REVIEWED

    Source sequence(s)
    AC079766, AK310788, BC088357, BM970269, CB127285, DA478550, L12136
    Consensus CDS
    CCDS3831.1
    Conserved Domains (1) summary
    cd01286
    Location:17138
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  4. NM_001351745.1NP_001338674.1  deoxycytidylate deaminase isoform b

    Status: REVIEWED

    Source sequence(s)
    AC079766, BM970269, BQ431673, BU188090, CX869988, L12136
    Consensus CDS
    CCDS3831.1
    Conserved Domains (1) summary
    cd01286
    Location:17138
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  5. NM_001351747.1NP_001338676.1  deoxycytidylate deaminase isoform b

    Status: REVIEWED

    Source sequence(s)
    AC079766, AK310788, BC088357, BM554139, BM970269, BQ431673, CR998876, L12136
    Consensus CDS
    CCDS3831.1
    Conserved Domains (1) summary
    cd01286
    Location:17138
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  6. NM_001351748.1NP_001338677.1  deoxycytidylate deaminase isoform b

    Status: REVIEWED

    Source sequence(s)
    BC088357, BG702996, BI544512, BM970269, CX869988, L12136
    Consensus CDS
    CCDS3831.1
    Conserved Domains (1) summary
    cd01286
    Location:17138
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  7. NM_001351750.1NP_001338679.1  deoxycytidylate deaminase isoform b

    Status: REVIEWED

    Source sequence(s)
    BG702996, BI669414, BM970269, BU188090, CX869988, L12136
    Consensus CDS
    CCDS3831.1
    Related
    ENSP00000424017.1, ENST00000510370.5
    Conserved Domains (1) summary
    cd01286
    Location:17138
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  8. NM_001351753.1NP_001338682.1  deoxycytidylate deaminase isoform b

    Status: REVIEWED

    Source sequence(s)
    AK310788, BC088357, BG702996, BM970269, DC358949, L12136
    Consensus CDS
    CCDS3831.1
    Conserved Domains (1) summary
    cd01286
    Location:17138
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  9. NM_001921.2NP_001912.2  deoxycytidylate deaminase isoform b

    See identical proteins and their annotated locations for NP_001912.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 through 9 encode the same isoform (9).
    Source sequence(s)
    AC079766, BC001286, BQ228061, BU188090
    Consensus CDS
    CCDS3831.1
    UniProtKB/Swiss-Prot
    P32321
    Related
    ENSP00000398194.2, ENST00000438320.6
    Conserved Domains (1) summary
    cd01286
    Location:17138
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    182890091..182917477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714115.3XP_006714178.1  deoxycytidylate deaminase isoform X3

    See identical proteins and their annotated locations for XP_006714178.1

    Conserved Domains (1) summary
    cl00269
    Location:2379
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
  2. XM_005262782.3XP_005262839.1  deoxycytidylate deaminase isoform X3

    See identical proteins and their annotated locations for XP_005262839.1

    Conserved Domains (1) summary
    cl00269
    Location:2379
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
  3. XM_005262781.4XP_005262838.1  deoxycytidylate deaminase isoform X3

    See identical proteins and their annotated locations for XP_005262838.1

    Conserved Domains (1) summary
    cl00269
    Location:2379
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
  4. XM_017007822.1XP_016863311.1  deoxycytidylate deaminase isoform X2

    UniProtKB/Swiss-Prot
    P32321
    Conserved Domains (1) summary
    cd01286
    Location:17138
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  5. XM_006714116.4XP_006714179.1  deoxycytidylate deaminase isoform X3

    See identical proteins and their annotated locations for XP_006714179.1

    Conserved Domains (1) summary
    cl00269
    Location:2379
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
  6. XM_011531675.3XP_011529977.1  deoxycytidylate deaminase isoform X3

    See identical proteins and their annotated locations for XP_011529977.1

    Conserved Domains (1) summary
    cl00269
    Location:2379
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
  7. XM_017007820.2XP_016863309.1  deoxycytidylate deaminase isoform X2

    UniProtKB/Swiss-Prot
    P32321
    Conserved Domains (1) summary
    cd01286
    Location:17138
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  8. XM_011531676.3XP_011529978.1  deoxycytidylate deaminase isoform X3

    See identical proteins and their annotated locations for XP_011529978.1

    Conserved Domains (1) summary
    cl00269
    Location:2379
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
  9. XM_011531674.3XP_011529976.1  deoxycytidylate deaminase isoform X2

    See identical proteins and their annotated locations for XP_011529976.1

    UniProtKB/Swiss-Prot
    P32321
    Conserved Domains (1) summary
    cd01286
    Location:17138
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  10. XM_005262778.3XP_005262835.1  deoxycytidylate deaminase isoform X1

    Conserved Domains (1) summary
    cd01286
    Location:28149
    deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...
  11. XM_017007824.1XP_016863313.1  deoxycytidylate deaminase isoform X3

    Conserved Domains (1) summary
    cl00269
    Location:2379
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
  12. XM_017007823.1XP_016863312.1  deoxycytidylate deaminase isoform X3

    Conserved Domains (1) summary
    cl00269
    Location:2379
    cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...
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