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PLPPR5 phospholipid phosphatase related 5 [ Homo sapiens (human) ]

Gene ID: 163404, updated on 22-Aug-2020

Summary

Official Symbol
PLPPR5provided by HGNC
Official Full Name
phospholipid phosphatase related 5provided by HGNC
Primary source
HGNC:HGNC:31703
See related
Ensembl:ENSG00000117598 MIM:617287
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAP2; PRG5; LPPR5; PAP2D
Summary
The protein encoded by this gene is a type 2 member of the phosphatidic acid phosphatase (PAP) family. All type 2 members of this protein family contain 6 transmembrane regions, and a consensus N-glycosylation site. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 3.8), testis (RPKM 1.2) and 1 other tissue See more
Orthologs

Genomic context

See PLPPR5 in Genome Data Viewer
Location:
1p21.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (98890245..99006130, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (99355801..99470449, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1776 Neighboring gene sorting nexin 7 Neighboring gene uncharacterized LOC100129620 Neighboring gene phospholipid phosphatase related 4 Neighboring gene uncharacterized LOC107985093

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association scan of dental caries in the permanent dentition.
GeneReviews: Not available
GWAS of dental caries patterns in the permanent dentition.
GeneReviews: Not available
Identification of a genetic variant at 2q12.1 associated with blood pressure in East-Asians by genome-wide scan including gene-environment interactions.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of filopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
phospholipid phosphatase-related protein type 5
Names
PRG-5
lipid phosphate phosphatase-related protein type 5
phosphatidic acid phosphatase 2d
phosphatidic acid phosphatase type 2
phosphatidic acid phosphatase type 2d
plasticity-related gene 5 protein
plasticity-related protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010861.3NP_001010861.1  phospholipid phosphatase-related protein type 5 isoform 2

    See identical proteins and their annotated locations for NP_001010861.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as PAP2d_v2, uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a protein (isoform 2) that is shorter than isoform 1.
    Source sequence(s)
    AF131783, AY634620, BC040174, BF514931, R37934
    Consensus CDS
    CCDS30779.1
    UniProtKB/Swiss-Prot
    Q32ZL2
    Related
    ENSP00000359207.3, ENST00000370188.7
    Conserved Domains (1) summary
    cd03384
    Location:118267
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
  2. NM_001037317.2NP_001032394.1  phospholipid phosphatase-related protein type 5 isoform 1

    See identical proteins and their annotated locations for NP_001032394.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as PAP2d_v1, represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF131783, AY574039, BC040174, DR001828, R37934
    Consensus CDS
    CCDS30778.1
    UniProtKB/Swiss-Prot
    Q32ZL2
    Related
    ENSP00000263177.4, ENST00000263177.5
    Conserved Domains (1) summary
    cd03384
    Location:118267
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    98890245..99006130 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540838.3XP_011539140.1  phospholipid phosphatase-related protein type 5 isoform X3

    See identical proteins and their annotated locations for XP_011539140.1

    Conserved Domains (1) summary
    cd03384
    Location:102251
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
  2. XM_011540836.2XP_011539138.1  phospholipid phosphatase-related protein type 5 isoform X1

    See identical proteins and their annotated locations for XP_011539138.1

    Conserved Domains (1) summary
    cd03384
    Location:118267
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
  3. XM_011540837.1XP_011539139.1  phospholipid phosphatase-related protein type 5 isoform X2

    Conserved Domains (1) summary
    cd03384
    Location:118267
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
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