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Ins2 insulin II [ Mus musculus (house mouse) ]

Gene ID: 16334, updated on 26-Jun-2024

Summary

Official Symbol
Ins2provided by MGI
Official Full Name
insulin IIprovided by MGI
Primary source
MGI:MGI:96573
See related
Ensembl:ENSMUSG00000000215 AllianceGenome:MGI:96573
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mody; Ins-2; InsII; Mody4
Summary
This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. The encoded precursor protein undergoes proteolytic cleavage to produce a disulfide-linked heterodimeric functional protein that is stored in secretory granules. An increase in blood glucose levels, among others, induces the release of insulin from the secretory granules. Mice deficient in the functional hormone encoded by this gene develop diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Expression
Biased expression in duodenum adult (RPKM 64.4), colon adult (RPKM 9.2) and 2 other tissues See more
Orthologs
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Genomic context

See Ins2 in Genome Data Viewer
Location:
7 F5; 7 88.0 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (142232393..142233463, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (142678656..142679726, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor 2 Neighboring gene microRNA 483 Neighboring gene insulin-like growth factor 2, opposite strand Neighboring gene predicted gene, 39116 Neighboring gene STARR-positive B cell enhancer mm9_chr7:149922840-149923140 Neighboring gene ribosomal protein L13 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables receptor ligand activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables zinc ion binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within ER overload response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
involved_in acute-phase response ISO
Inferred from Sequence Orthology
more info
 
involved_in alpha-beta T cell activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucose transmembrane transport TAS
Traceable Author Statement
more info
PubMed 
involved_in insulin processing IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in insulin processing ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within myoblast fusion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within myotube differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of NAD(P)H oxidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glycogen catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of respiratory burst involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron projection maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in nitric oxide-cGMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of lipid kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of respiratory burst ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_positive_effect receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cellular amino acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with secretory granule ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 
part_of sno(s)RNA-containing ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185083.2NP_001172012.1  insulin-2 preproprotein

    See identical proteins and their annotated locations for NP_001172012.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    BC099934, BP775562
    Consensus CDS
    CCDS22034.1
    UniProtKB/Swiss-Prot
    P01326
    UniProtKB/TrEMBL
    D0EY27, Q5EEX1
    Related
    ENSMUSP00000101552.2, ENSMUST00000105932.2
    Conserved Domains (1) summary
    cd04367
    Location:26110
    IlGF_insulin_like; IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and ...
  2. NM_001185084.2NP_001172013.1  insulin-2 preproprotein

    See identical proteins and their annotated locations for NP_001172013.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AY899305, BC099934, BP775562
    Consensus CDS
    CCDS22034.1
    UniProtKB/Swiss-Prot
    P01326
    UniProtKB/TrEMBL
    D0EY27, Q5EEX1
    Related
    ENSMUSP00000101553.2, ENSMUST00000105933.8
    Conserved Domains (1) summary
    cd04367
    Location:26110
    IlGF_insulin_like; IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and ...
  3. NM_008387.5NP_032413.1  insulin-2 preproprotein

    See identical proteins and their annotated locations for NP_032413.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK007612, BC099934, BP775562
    Consensus CDS
    CCDS22034.1
    UniProtKB/Swiss-Prot
    P01326
    UniProtKB/TrEMBL
    D0EY27, Q5EEX1
    Related
    ENSMUSP00000000220.3, ENSMUST00000000220.3
    Conserved Domains (1) summary
    cd04367
    Location:26110
    IlGF_insulin_like; IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    142232393..142233463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)