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Ins2 insulin II [ Mus musculus (house mouse) ]

Gene ID: 16334, updated on 12-Jun-2018
Official Symbol
Ins2provided by MGI
Official Full Name
insulin IIprovided by MGI
Primary source
MGI:MGI:96573
See related
Ensembl:ENSMUSG00000000215 Vega:OTTMUSG00000018794
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mody; Ins-2; InsII; Mody4; AA986540
Summary
This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. The encoded precursor protein undergoes proteolytic cleavage to produce a disulfide-linked heterodimeric functional protein that is stored in secretory granules. An increase in blood glucose levels, among others, induces the release of insulin from the secretory granules. Mice deficient in the functional hormone encoded by this gene develop diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Expression
Biased expression in duodenum adult (RPKM 64.4), colon adult (RPKM 9.2) and 2 other tissues See more
Orthologs
See Ins2 in Genome Data Viewer
Location:
7 F5; 7 88.0 cM
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (142678656..142679726, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (149864561..149865613, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene insulin-like growth factor 2 Neighboring gene microRNA 483 Neighboring gene insulin-like growth factor 2, opposite strand Neighboring gene predicted gene, 46005 Neighboring gene predicted gene, 39116 Neighboring gene ribosomal protein L13 pseudogene

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hormone activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
insulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
protease binding ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
ER overload response IMP
Inferred from Mutant Phenotype
more info
PubMed 
G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
NOT activation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of MAPK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of MAPK activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
acute-phase response ISO
Inferred from Sequence Orthology
more info
 
alpha-beta T cell activation ISO
Inferred from Sequence Orthology
more info
 
canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid homeostasis ISO
Inferred from Sequence Orthology
more info
 
glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose transmembrane transport TAS
Traceable Author Statement
more info
PubMed 
insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
myoblast fusion IGI
Inferred from Genetic Interaction
more info
PubMed 
myotube differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of NAD(P)H oxidase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glycogen catabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein oligomerization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of respiratory burst involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection maintenance ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendritic spine maintenance ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glucose import in response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glycogen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric oxide mediated signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of respiratory burst ISO
Inferred from Sequence Orthology
more info
 
regulation of cellular amino acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
regulation of phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
regulation of transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
response to glucose IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to insulin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to nutrient levels IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to organic substance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
COLOCALIZES_WITH cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with secretory granule ISO
Inferred from Sequence Orthology
more info
 
small nucleolar ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185083.2NP_001172012.1  insulin-2 preproprotein

    See identical proteins and their annotated locations for NP_001172012.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    BC099934, BP775562
    Consensus CDS
    CCDS22034.1
    UniProtKB/Swiss-Prot
    P01326
    UniProtKB/TrEMBL
    Q5EEX1
    Related
    ENSMUSP00000101552.1, OTTMUSP00000020355, ENSMUST00000105932.1, OTTMUST00000045251
    Conserved Domains (1) summary
    cd04367
    Location:26110
    IlGF_insulin_like; IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and ...
  2. NM_001185084.2NP_001172013.1  insulin-2 preproprotein

    See identical proteins and their annotated locations for NP_001172013.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AY899305, BC099934, BP775562
    Consensus CDS
    CCDS22034.1
    UniProtKB/Swiss-Prot
    P01326
    UniProtKB/TrEMBL
    Q5EEX1
    Related
    ENSMUSP00000101553.1, OTTMUSP00000020352, ENSMUST00000105933.7, OTTMUST00000045248
    Conserved Domains (1) summary
    cd04367
    Location:26110
    IlGF_insulin_like; IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and ...
  3. NM_008387.5NP_032413.1  insulin-2 preproprotein

    See identical proteins and their annotated locations for NP_032413.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK007612, BC099934, BP775562
    Consensus CDS
    CCDS22034.1
    UniProtKB/Swiss-Prot
    P01326
    UniProtKB/TrEMBL
    Q5EEX1
    Related
    ENSMUSP00000000220.2, OTTMUSP00000020351, ENSMUST00000000220.2, OTTMUST00000045247
    Conserved Domains (1) summary
    cd04367
    Location:26110
    IlGF_insulin_like; IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    142678656..142679726 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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