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Ins1 insulin I [ Mus musculus (house mouse) ]

Gene ID: 16333, updated on 22-Nov-2020

Summary

Official Symbol
Ins1provided by MGI
Official Full Name
insulin Iprovided by MGI
Primary source
MGI:MGI:96572
See related
Ensembl:ENSMUSG00000035804
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ins-1; Ins2-rs1
Summary
This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. The encoded precursor protein undergoes proteolytic cleavage to produce a disulfide-linked heterodimeric functional protein that is stored in secretory granules. An increase in blood glucose levels, among others, induces the release of insulin from the secretory granules. Mice deficient in the functional hormone encoded by this gene develop diabetes mellitus. [provided by RefSeq, Aug 2015]
Expression
Biased expression in duodenum adult (RPKM 26.6), small intestine adult (RPKM 6.5) and 2 other tissues See more

Genomic context

See Ins1 in Genome Data Viewer
Location:
19 D2; 19 46.76 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (52252735..52253453)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (52264297..52265015)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (52338813..52339966)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31, pseudogene 18 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene predicted gene, 41860 Neighboring gene expressed sequence AA387883

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hormone activity IEA
Inferred from Electronic Annotation
more info
 
insulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
activation of MAPK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
endocrine pancreas development TAS
Traceable Author Statement
more info
 
glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
glucose transmembrane transport TAS
Traceable Author Statement
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to organic substance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
colocalizes_with cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
secretory granule lumen TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008386.4NP_032412.3  insulin-1 preproprotein

    See identical proteins and their annotated locations for NP_032412.3

    Status: REVIEWED

    Source sequence(s)
    AC163452, AK008358, BP773571, BQ126282
    Consensus CDS
    CCDS29898.1
    UniProtKB/Swiss-Prot
    P01325
    Related
    ENSMUSP00000049095.4, ENSMUST00000039652.5
    Conserved Domains (1) summary
    cd04367
    Location:26108
    IlGF_insulin_like; IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    52252735..52253453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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