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Inpp5d inositol polyphosphate-5-phosphatase D [ Mus musculus (house mouse) ]

Gene ID: 16331, updated on 5-Mar-2024

Summary

Official Symbol
Inpp5dprovided by MGI
Official Full Name
inositol polyphosphate-5-phosphatase Dprovided by MGI
Primary source
MGI:MGI:107357
See related
Ensembl:ENSMUSG00000026288 AllianceGenome:MGI:107357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SHIP; SHIP1; SHIP-1; s-SHIP; SIP-145; p150Ship
Summary
Enables phosphatase activity and protein domain specific binding activity. Acts upstream of or within several processes, including negative regulation of B cell proliferation; negative regulation of bone resorption; and regulation of hemopoiesis. Predicted to be located in actin filament; cortical cytoskeleton; and cytosol. Predicted to colocalize with plasma membrane. Is expressed in several structures, including integumental system; nervous system; respiratory system; skeleton; and spleen. Used to study Paget's disease of bone and systemic lupus erythematosus. Orthologous to human INPP5D (inositol polyphosphate-5-phosphatase D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 30.1), genital fat pad adult (RPKM 21.2) and 20 other tissues See more
Orthologs
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Genomic context

See Inpp5d in Genome Data Viewer
Location:
1 D; 1 44.44 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (87548034..87648232)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (87620312..87720510)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene neuronal guanine nucleotide exchange factor Neighboring gene predicted gene, 46099 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:89504315-89504498 Neighboring gene neuraminidase 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:89523069-89523293 Neighboring gene STARR-positive B cell enhancer ABC_E2553 Neighboring gene STARR-seq mESC enhancer starr_01618 Neighboring gene STARR-seq mESC enhancer starr_01619 Neighboring gene predicted gene, 33470 Neighboring gene STARR-seq mESC enhancer starr_01622 Neighboring gene predicted gene, 33517 Neighboring gene STARR-positive B cell enhancer ABC_E1554 Neighboring gene autophagy related 16 like 1 Neighboring gene predicted gene, 25395

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC117680

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol-1,4,5-trisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables inositol-4,5-bisphosphate 5-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immunoglobulin mediated immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of B cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of granulocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of monocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neutrophil differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of neutrophil differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of lymphocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in cortical cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Names
SH2 domain-containing inositol 5'-phosphatase 1
SH2 domain-containing inositol phosphatase 1
SH2-containing inositol phosphatase SHIP
Src homology 2 domain-containing inositol-5-phosphatase
inositol polyphosphate-5-phosphatase, 145 kDa
phosphatidylinositol-4,5-bisphosphate 5-phosphatase
NP_001103662.1
NP_001103663.1
NP_034696.2
XP_006529212.1
XP_006529213.1
XP_006529214.1
XP_006529217.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110192.2NP_001103662.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 2

    See identical proteins and their annotated locations for NP_001103662.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC102564, AC159967, AK143560, BY197864, U39203
    Consensus CDS
    CCDS48311.1
    UniProtKB/Swiss-Prot
    Q9ES52
    Related
    ENSMUSP00000044647.9, ENSMUST00000042275.15
    Conserved Domains (2) summary
    cd09100
    Location:406712
    INPP5c_SHIP1-INPP5D; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol polyphosphate 5-phosphatase-1 and related proteins
    cd10343
    Location:4105
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
  2. NM_001110193.2NP_001103663.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 3

    See identical proteins and their annotated locations for NP_001103663.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains two alternate in-frame exons in the 3' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC102564, AC159967
    Consensus CDS
    CCDS48310.1
    UniProtKB/Swiss-Prot
    Q9ES52
    Related
    ENSMUSP00000131244.2, ENSMUST00000168783.8
    Conserved Domains (2) summary
    cd09100
    Location:407713
    INPP5c_SHIP1-INPP5D; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol polyphosphate 5-phosphatase-1 and related proteins
    cd10343
    Location:4105
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
  3. NM_010566.3NP_034696.2  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform 1

    See identical proteins and their annotated locations for NP_034696.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC159967, AK143560, BY197864
    Consensus CDS
    CCDS35655.1
    UniProtKB/Swiss-Prot
    Q3UPF9, Q4U212, Q61034, Q61173, Q61181, Q9ES52, Q9JKR7, Q9JLF9, Q9JLG0, Q9QVN8, Q9WUC2
    Related
    ENSMUSP00000127941.2, ENSMUST00000169754.8
    Conserved Domains (2) summary
    cd09100
    Location:407713
    INPP5c_SHIP1-INPP5D; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol polyphosphate 5-phosphatase-1 and related proteins
    cd10343
    Location:4105
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)

RNA

  1. NR_122078.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains two alternate internal exons and uses an alternate splice in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC102564, AC159967
    Related
    ENSMUST00000072999.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    87548034..87648232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529149.3XP_006529212.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1

    Conserved Domains (2) summary
    cd09100
    Location:407713
    INPP5c_SHIP1-INPP5D; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol polyphosphate 5-phosphatase-1 and related proteins
    cd10343
    Location:4105
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
  2. XM_006529151.3XP_006529214.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X3

    Conserved Domains (2) summary
    cd09100
    Location:407713
    INPP5c_SHIP1-INPP5D; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol polyphosphate 5-phosphatase-1 and related proteins
    cd10343
    Location:4105
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
  3. XM_006529150.4XP_006529213.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X2

    Conserved Domains (2) summary
    cd09100
    Location:406712
    INPP5c_SHIP1-INPP5D; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of SH2 domain containing inositol polyphosphate 5-phosphatase-1 and related proteins
    cd10343
    Location:4105
    SH2_SHIP; Src homology 2 (SH2) domain found in SH2-containing inositol-5'-phosphatase (SHIP) and SLAM-associated protein (SAP)
  4. XM_006529154.5XP_006529217.1  phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X4

    Conserved Domains (1) summary
    cl00490
    Location:43155
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

RNA

  1. XR_003952973.2 RNA Sequence

  2. XR_001782395.2 RNA Sequence