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DCK deoxycytidine kinase [ Homo sapiens (human) ]

Gene ID: 1633, updated on 7-Dec-2018

Summary

Official Symbol
DCKprovided by HGNC
Official Full Name
deoxycytidine kinaseprovided by HGNC
Primary source
HGNC:HGNC:2704
See related
Ensembl:ENSG00000156136 MIM:125450
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 50.3), appendix (RPKM 23.2) and 22 other tissues See more
Orthologs

Genomic context

See DCK in Genome Data Viewer
Location:
4q13.3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (70993548..71030914)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (71859265..71896631)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 891, pseudogene Neighboring gene MOB kinase activator 1B Neighboring gene solute carrier family 4 member 4 Neighboring gene probable UDP-sugar transporter protein SLC35A4 Neighboring gene lactate dehydrogenase A like 6E, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117410, MGC138632

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
deoxycytidine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
deoxycytidine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
deoxynucleoside kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleoside kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
deoxyribonucleoside monophosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
purine-containing compound salvage TAS
Traceable Author Statement
more info
 
pyrimidine nucleoside salvage TAS
Traceable Author Statement
more info
 
pyrimidine nucleotide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
deoxycytidine kinase
Names
deoxynucleoside kinase
NP_000779.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023303.1 RefSeqGene

    Range
    5001..42367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000788.3NP_000779.1  deoxycytidine kinase

    See identical proteins and their annotated locations for NP_000779.1

    Status: REVIEWED

    Source sequence(s)
    BC103764, BI601939, CD014016
    Consensus CDS
    CCDS3548.1
    UniProtKB/Swiss-Prot
    P27707
    UniProtKB/TrEMBL
    F5CTF3
    Related
    ENSP00000286648.5, ENST00000286648.9
    Conserved Domains (1) summary
    pfam01712
    Location:24258
    dNK; Deoxynucleoside kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    70993548..71030914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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