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DENND2C DENN domain containing 2C [ Homo sapiens (human) ]

Gene ID: 163259, updated on 4-May-2020

Summary

Official Symbol
DENND2Cprovided by HGNC
Official Full Name
DENN domain containing 2Cprovided by HGNC
Primary source
HGNC:HGNC:24748
See related
Ensembl:ENSG00000175984
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ1156J9.1
Expression
Biased expression in esophagus (RPKM 11.0), skin (RPKM 6.6) and 10 other tissues See more
Orthologs

Genomic context

See DENND2C in Genome Data Viewer
Location:
1p13.2
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (114582850..114670049, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (115127155..115212732, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378913 Neighboring gene uncharacterized LOC105378914 Neighboring gene BCAS2 pre-mRNA processing factor Neighboring gene adenosine monophosphate deaminase 1 Neighboring gene RNA, 7SL, cytoplasmic 432, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: BCAS2

Potential readthrough

Included gene: AMPD1

Homology

Clone Names

  • FLJ37099, DKFZp686G0351, DKFZp686N1631, DKFZp779P1149

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rab guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rab guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DENN domain-containing protein 2C
Names
DENN/MADD domain containing 2C
RP5-1156J9.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256404.2NP_001243333.1  DENN domain-containing protein 2C isoform 1

    See identical proteins and their annotated locations for NP_001243333.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer variant and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AL096773, AL133382, AL390241, BX647950
    Consensus CDS
    CCDS58018.1
    UniProtKB/Swiss-Prot
    Q68D51
    Related
    ENSP00000376955.1, ENST00000393274.6
    Conserved Domains (3) summary
    smart00801
    Location:815881
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:487576
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:586770
    DENN; DENN (AEX-3) domain
  2. NM_198459.4NP_940861.3  DENN domain-containing protein 2C isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons in the 5' UTR and in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
    Source sequence(s)
    AL133382, AL390241, BC063894, BX647950, DB071246
    Consensus CDS
    CCDS875.1
    UniProtKB/Swiss-Prot
    Q68D51
    Related
    ENSP00000376957.3, ENST00000393276.7
    Conserved Domains (3) summary
    smart00801
    Location:758824
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:430519
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    pfam02141
    Location:529713
    DENN; DENN (AEX-3) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    114582850..114670049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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