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Inhba inhibin beta-A [ Mus musculus (house mouse) ]

Gene ID: 16323, updated on 7-Aug-2018

Summary

Official Symbol
Inhbaprovided by MGI
Official Full Name
inhibin beta-Aprovided by MGI
Primary source
MGI:MGI:96570
See related
Ensembl:ENSMUSG00000041324
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Homozygous knockout mice for this gene lack whiskers and exhibit tooth and palate defects, leading to neonatal lethality. [provided by RefSeq, Aug 2016]
Expression
Biased expression in ovary adult (RPKM 8.8), liver E18 (RPKM 1.2) and 5 other tissues See more
Orthologs

Genomic context

See Inhba in Genome Data Viewer
Location:
13 A1; 13 5.85 cM
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (16007743..16027723)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (16106308..16119044)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A530046M15 gene Neighboring gene U1 small nuclear ribonucleoprotein 1C pseudogene Neighboring gene predicted gene, 31450 Neighboring gene predicted gene 6562 Neighboring gene predicted gene, 31711

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine activity ISO
Inferred from Sequence Orthology
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
hormone activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
inhibin binding ISO
Inferred from Sequence Orthology
more info
 
peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
type II activin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
GABAergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to cholesterol ISO
Inferred from Sequence Orthology
more info
 
cellular response to follicle-stimulating hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
endodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
eyelid development in camera-type eye IGI
Inferred from Genetic Interaction
more info
PubMed 
hair follicle development ISO
Inferred from Sequence Orthology
more info
 
hematopoietic progenitor cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
hemoglobin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
male gonad development ISO
Inferred from Sequence Orthology
more info
 
mesoderm formation IDA
Inferred from Direct Assay
more info
PubMed 
mesodermal cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of hair follicle development ISO
Inferred from Sequence Orthology
more info
PubMed 
odontogenesis ISO
Inferred from Sequence Orthology
more info
 
ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ovulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
progesterone secretion ISO
Inferred from Sequence Orthology
more info
 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of follicle-stimulating hormone secretion ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
response to drug ISO
Inferred from Sequence Orthology
more info
 
roof of mouth development ISO
Inferred from Sequence Orthology
more info
 
striatal medium spiny neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
activin A complex ISO
Inferred from Sequence Orthology
more info
 
extracellular region ISO
Inferred from Sequence Orthology
more info
 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
inhibin A complex ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
inhibin beta A chain
Names
activin A
activin beta-A chain

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008380.2NP_032406.1  inhibin beta A chain preproprotein

    See identical proteins and their annotated locations for NP_032406.1

    Status: REVIEWED

    Source sequence(s)
    AC154742, AC161586, AK134991, BP759054
    Consensus CDS
    CCDS26251.1
    UniProtKB/Swiss-Prot
    Q04998
    UniProtKB/TrEMBL
    Q3UY39
    Related
    ENSMUSP00000132085.1, ENSMUST00000164993.1
    Conserved Domains (2) summary
    smart00204
    Location:319424
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:56291
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

    Range
    16007743..16027723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244285.2XP_011242587.1  inhibin beta A chain isoform X1

    See identical proteins and their annotated locations for XP_011242587.1

    UniProtKB/Swiss-Prot
    Q04998
    UniProtKB/TrEMBL
    Q3UY39
    Conserved Domains (2) summary
    smart00204
    Location:319424
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:56291
    TGFb_propeptide; TGF-beta propeptide
  2. XM_011244286.1XP_011242588.1  inhibin beta A chain isoform X1

    See identical proteins and their annotated locations for XP_011242588.1

    UniProtKB/Swiss-Prot
    Q04998
    UniProtKB/TrEMBL
    Q3UY39
    Conserved Domains (2) summary
    smart00204
    Location:319424
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:56291
    TGFb_propeptide; TGF-beta propeptide
  3. XM_006516559.2XP_006516622.1  inhibin beta A chain isoform X1

    See identical proteins and their annotated locations for XP_006516622.1

    UniProtKB/Swiss-Prot
    Q04998
    UniProtKB/TrEMBL
    Q3UY39
    Conserved Domains (2) summary
    smart00204
    Location:319424
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:56291
    TGFb_propeptide; TGF-beta propeptide
  4. XM_006516558.2XP_006516621.1  inhibin beta A chain isoform X1

    See identical proteins and their annotated locations for XP_006516621.1

    UniProtKB/Swiss-Prot
    Q04998
    UniProtKB/TrEMBL
    Q3UY39
    Related
    ENSMUSP00000047894.6, ENSMUST00000042603.13
    Conserved Domains (2) summary
    smart00204
    Location:319424
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:56291
    TGFb_propeptide; TGF-beta propeptide
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