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Inhba inhibin beta-A [ Mus musculus (house mouse) ]

Gene ID: 16323, updated on 5-Apr-2024

Summary

Official Symbol
Inhbaprovided by MGI
Official Full Name
inhibin beta-Aprovided by MGI
Primary source
MGI:MGI:96570
See related
Ensembl:ENSMUSG00000041324 AllianceGenome:MGI:96570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Homozygous knockout mice for this gene lack whiskers and exhibit tooth and palate defects, leading to neonatal lethality. [provided by RefSeq, Aug 2016]
Expression
Biased expression in ovary adult (RPKM 8.8), liver E18 (RPKM 1.2) and 5 other tissues See more
Orthologs
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Genomic context

See Inhba in Genome Data Viewer
Location:
13 A1; 13 5.85 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (16178841..16206194)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (16004256..16031609)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A530046M15 gene Neighboring gene U1 small nuclear ribonucleoprotein 1C pseudogene Neighboring gene STARR-seq mESC enhancer starr_33739 Neighboring gene predicted gene, 31450 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:16104285-16104394 Neighboring gene predicted gene, 22628 Neighboring gene predicted gene 6562

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine activity ISO
Inferred from Sequence Orthology
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables type II activin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in GABAergic neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac fibroblast cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cholesterol ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to follicle-stimulating hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in endodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in eyelid development in camera-type eye IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of hair follicle development ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in hair follicle development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in hemoglobin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in male gonad development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mesoderm formation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mesodermal cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of hair follicle development ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in odontogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ovulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in progesterone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of follicle-stimulating hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in roof of mouth development ISO
Inferred from Sequence Orthology
more info
 
involved_in striatal medium spiny neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of activin A complex ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of inhibin A complex ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
inhibin beta A chain
Names
activin A
activin beta-A chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008380.2NP_032406.1  inhibin beta A chain preproprotein

    See identical proteins and their annotated locations for NP_032406.1

    Status: REVIEWED

    Source sequence(s)
    AC154742, AC161586, AK134991, BP759054
    Consensus CDS
    CCDS26251.1
    UniProtKB/Swiss-Prot
    Q04998
    UniProtKB/TrEMBL
    Q3UY39, Q4FJM4
    Related
    ENSMUSP00000047894.7, ENSMUST00000042603.14
    Conserved Domains (2) summary
    pfam00688
    Location:56291
    TGFb_propeptide; TGF-beta propeptide
    cd19404
    Location:317424
    TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    16178841..16206194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244285.3XP_011242587.1  inhibin beta A chain isoform X1

    See identical proteins and their annotated locations for XP_011242587.1

    UniProtKB/Swiss-Prot
    Q04998
    UniProtKB/TrEMBL
    Q3UY39, Q4FJM4
    Related
    ENSMUSP00000132085.2, ENSMUST00000164993.2
    Conserved Domains (2) summary
    pfam00688
    Location:56291
    TGFb_propeptide; TGF-beta propeptide
    cd19404
    Location:317424
    TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins
  2. XM_006516559.4XP_006516622.1  inhibin beta A chain isoform X1

    See identical proteins and their annotated locations for XP_006516622.1

    UniProtKB/Swiss-Prot
    Q04998
    UniProtKB/TrEMBL
    Q3UY39, Q4FJM4
    Conserved Domains (2) summary
    pfam00688
    Location:56291
    TGFb_propeptide; TGF-beta propeptide
    cd19404
    Location:317424
    TGF_beta_INHBA; transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins