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ECI1 enoyl-CoA delta isomerase 1 [ Homo sapiens (human) ]

Gene ID: 1632, updated on 1-Jun-2020

Summary

Official Symbol
ECI1provided by HGNC
Official Full Name
enoyl-CoA delta isomerase 1provided by HGNC
Primary source
HGNC:HGNC:2703
See related
Ensembl:ENSG00000167969 MIM:600305
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCI
Summary
This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in kidney (RPKM 39.8), colon (RPKM 22.9) and 25 other tissues See more
Orthologs

Genomic context

See ECI1 in Genome Data Viewer
Location:
16p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (2239402..2251587, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2289873..2302296, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene E4F transcription factor 1 Neighboring gene deoxyribonuclease 1 like 2 Neighboring gene uncharacterized LOC107984839 Neighboring gene RNA binding protein with serine rich domain 1 Neighboring gene uncharacterized LOC106660606 Neighboring gene microRNA 3677

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of enoyl-CoA delta isomerase 1 (ECI1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dodecenoyl-CoA delta-isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
dodecenoyl-CoA delta-isomerase activity NAS
Non-traceable Author Statement
more info
PubMed 
enoyl-CoA hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intramolecular oxidoreductase activity, transposing C=C bonds ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
fatty acid beta-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid beta-oxidation NAS
Non-traceable Author Statement
more info
PubMed 
fatty acid beta-oxidation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial matrix NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
enoyl-CoA delta isomerase 1, mitochondrial
Names
3,2 trans-enoyl-Coenzyme A isomerase
3,2-trans-enoyl-CoA isomerase, mitochondrial
D3,D2-enoyl-CoA isomerase
acetylene-allene isomerase
delta(3),Delta(2)-enoyl-CoA isomerase
dodecenoyl-CoA delta isomerase (3,2 trans-enoyl-CoA isomerase)
dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenzyme A isomerase)
epididymis secretory sperm binding protein
NP_001171500.1
NP_001910.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047046.1 RefSeqGene

    Range
    5015..17200
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178029.2NP_001171500.1  enoyl-CoA delta isomerase 1, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_001171500.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the CDS, as compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC009065, AK291127, BC002746, BQ773923
    Consensus CDS
    CCDS58410.1
    UniProtKB/Swiss-Prot
    P42126
    Related
    ENSP00000456319.1, ENST00000562238.5
    Conserved Domains (1) summary
    pfam00378
    Location:52283
    ECH_1; Enoyl-CoA hydratase/isomerase
  2. NM_001919.4NP_001910.2  enoyl-CoA delta isomerase 1, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_001910.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC009065, AK291127, BQ773923
    Consensus CDS
    CCDS10464.1
    UniProtKB/Swiss-Prot
    P42126
    Related
    ENSP00000301729.4, ENST00000301729.9
    Conserved Domains (1) summary
    pfam00378
    Location:52298
    ECH_1; Enoyl-CoA hydratase/isomerase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    2239402..2251587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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