U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Incenp inner centromere protein [ Mus musculus (house mouse) ]

Gene ID: 16319, updated on 27-Nov-2024

Summary

Official Symbol
Incenpprovided by MGI
Official Full Name
inner centromere proteinprovided by MGI
Primary source
MGI:MGI:1313288
See related
Ensembl:ENSMUSG00000024660 AllianceGenome:MGI:1313288
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C130081E20; 2700067E22Rik
Summary
Predicted to enable molecular function activator activity. Predicted to be involved in meiotic spindle midzone assembly; metaphase chromosome alignment; and mitotic cytokinesis. Located in several cellular components, including chromocenter; midbody; and synaptonemal complex. Is expressed in brain ventricular layer; cerebral cortex subventricular zone; and heart. Orthologous to human INCENP (inner centromere protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver E14 (RPKM 26.8), CNS E11.5 (RPKM 25.6) and 19 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Incenp in Genome Data Viewer
Location:
19 A; 19 6.1 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (9849659..9876853, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (9872295..9899489, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45524 Neighboring gene syntaxin-binding protein 3, pseudogene Neighboring gene STARR-seq mESC enhancer starr_45526 Neighboring gene STARR-seq mESC enhancer starr_45527 Neighboring gene STARR-seq mESC enhancer starr_45528 Neighboring gene STARR-seq mESC enhancer starr_45529 Neighboring gene STARR-seq mESC enhancer starr_45530 Neighboring gene STARR-seq mESC enhancer starr_45531 Neighboring gene secretoglobin, family 2A, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E1972 Neighboring gene STARR-seq mESC enhancer starr_45534 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene predicted gene, 50340 Neighboring gene STARR-positive B cell enhancer ABC_E5686 Neighboring gene predicted gene, 36913 Neighboring gene predicted gene, 41806

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular function activator activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
 
involved_in chromosome segregation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in meiotic spindle midzone assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in metaphase chromosome alignment IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mitotic cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitotic cytokinesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mitotic spindle midzone assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mitotic spindle organization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of mitotic cytokinesis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of mitotic sister chromatid separation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in central element IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromocenter IDA
Inferred from Direct Assay
more info
PubMed 
part_of chromosome passenger complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of chromosome passenger complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in chromosome, centromeric region ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lateral element IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in meiotic spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in pericentric heterochromatin ISO
Inferred from Sequence Orthology
more info
 
located_in pericentric heterochromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 
located_in spindle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synaptonemal complex IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369356.1NP_001356285.1  inner centromere protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132253
    Consensus CDS
    CCDS89338.1
    UniProtKB/Swiss-Prot
    Q7TN28, Q8BGN4, Q8CGI4, Q9WU62
    Related
    ENSMUSP00000157547.2, ENSMUST00000237439.2
    Conserved Domains (3) summary
    PTZ00121
    Location:513656
    PTZ00121; MAEBL; Provisional
    pfam03941
    Location:795849
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:641
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
  2. NM_016692.4NP_057901.2  inner centromere protein isoform 2

    See identical proteins and their annotated locations for NP_057901.2

    Status: VALIDATED

    Source sequence(s)
    AC132253
    Consensus CDS
    CCDS37912.1
    UniProtKB/Swiss-Prot
    Q9WU62
    Related
    ENSMUSP00000025562.8, ENSMUST00000025562.9
    Conserved Domains (4) summary
    pfam03941
    Location:795846
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam12178
    Location:641
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
    cd16269
    Location:588599
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:515619
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    9849659..9876853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526708.2XP_006526771.2  inner centromere protein isoform X2

    Conserved Domains (4) summary
    PTZ00121
    Location:503659
    PTZ00121; MAEBL; Provisional
    pfam03941
    Location:798852
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam09726
    Location:394595
    Macoilin; Macoilin family
    pfam12178
    Location:1348
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
  2. XM_006526710.2XP_006526773.2  inner centromere protein isoform X4

    Conserved Domains (4) summary
    PTZ00121
    Location:520625
    PTZ00121; MAEBL; Provisional
    pfam03941
    Location:762816
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam09726
    Location:394582
    Macoilin; Macoilin family
    pfam12178
    Location:1348
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
  3. XM_011247154.1XP_011245456.1  inner centromere protein isoform X3

    Conserved Domains (4) summary
    PTZ00121
    Location:516663
    PTZ00121; MAEBL; Provisional
    pfam03941
    Location:782836
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam09726
    Location:394599
    Macoilin; Macoilin family
    pfam12178
    Location:1348
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
  4. XM_006526707.2XP_006526770.2  inner centromere protein isoform X1

    Conserved Domains (4) summary
    PTZ00121
    Location:520663
    PTZ00121; MAEBL; Provisional
    pfam03941
    Location:802856
    INCENP_ARK-bind; Inner centromere protein, ARK binding region
    pfam09726
    Location:394599
    Macoilin; Macoilin family
    pfam12178
    Location:1348
    INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal