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ZNF383 zinc finger protein 383 [ Homo sapiens (human) ]

Gene ID: 163087, updated on 21-Aug-2021

Summary

Official Symbol
ZNF383provided by HGNC
Official Full Name
zinc finger protein 383provided by HGNC
Primary source
HGNC:HGNC:18609
See related
Ensembl:ENSG00000188283 MIM:619499
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSD17; Zfp383
Summary
The protein encoded by this gene is a KRAB-related zinc finger protein that inhibits the transcription of some MAPK signaling pathway genes. The repressor activity resides in the KRAB domain of the encoded protein. [provided by RefSeq, Sep 2016]
Expression
Ubiquitous expression in thyroid (RPKM 1.1), ovary (RPKM 1.1) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF383 in Genome Data Viewer
Location:
19q13.12
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (37217243..37248740)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37709116..37739642)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 585A Neighboring gene Sharpr-MPRA regulatory region 11816 Neighboring gene zinc finger protein 585B Neighboring gene long intergenic non-protein coding RNA 1535 Neighboring gene uncharacterized LOC284412

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genetics of coronary artery calcification among African Americans, a meta-analysis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35863

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001345947.2NP_001332876.1  zinc finger protein 383

    Status: REVIEWED

    Source sequence(s)
    AC012309, AC016590, KC877738
    Consensus CDS
    CCDS12501.1
    UniProtKB/Swiss-Prot
    Q8NA42
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:231475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:170192
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:212237
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001345948.2NP_001332877.1  zinc finger protein 383

    Status: REVIEWED

    Source sequence(s)
    AC012309, AC016590, KC877738
    Consensus CDS
    CCDS12501.1
    UniProtKB/Swiss-Prot
    Q8NA42
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:231475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:170192
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:212237
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001345949.3NP_001332878.1  zinc finger protein 383

    Status: REVIEWED

    Source sequence(s)
    AC012309, AC016590, KC877738
    Consensus CDS
    CCDS12501.1
    UniProtKB/Swiss-Prot
    Q8NA42
    Related
    ENSP00000464871.1, ENST00000589413.5
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:231475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:170192
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:212237
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001387593.1NP_001374522.1  zinc finger protein 383

    Status: REVIEWED

    Source sequence(s)
    AC012309, AC016590, KC877738
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:231475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:170192
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:212237
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001387594.1NP_001374523.1  zinc finger protein 383

    Status: REVIEWED

    Source sequence(s)
    AC012309, AC016590, KC877738
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:231475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:170192
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:212237
    zf-H2C2_2; Zinc-finger double domain
  6. NM_001387595.1NP_001374524.1  zinc finger protein 383

    Status: REVIEWED

    Source sequence(s)
    AC012309, AC016590, KC877738
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:231475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:170192
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:212237
    zf-H2C2_2; Zinc-finger double domain
  7. NM_001387596.1NP_001374525.1  zinc finger protein 383

    Status: REVIEWED

    Source sequence(s)
    AC012309, AC016590, KC877738
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:231475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:170192
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:212237
    zf-H2C2_2; Zinc-finger double domain
  8. NM_001387597.1NP_001374526.1  zinc finger protein 383

    Status: REVIEWED

    Source sequence(s)
    AC012309, AC016590, KC877738
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:231475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:170192
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:212237
    zf-H2C2_2; Zinc-finger double domain
  9. NM_001387598.1NP_001374527.1  zinc finger protein 383

    Status: REVIEWED

    Source sequence(s)
    AC012309, AC016590, KC877738
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:231475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:170192
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:212237
    zf-H2C2_2; Zinc-finger double domain
  10. NM_001387599.1NP_001374528.1  zinc finger protein 383

    Status: REVIEWED

    Source sequence(s)
    AC012309, AC016590, KC877738
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:231475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:170192
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:212237
    zf-H2C2_2; Zinc-finger double domain
  11. NM_001387600.1NP_001374529.1  zinc finger protein 383

    Status: REVIEWED

    Source sequence(s)
    AC012309, AC016590, KC877738
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:231475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:170192
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:212237
    zf-H2C2_2; Zinc-finger double domain
  12. NM_001387601.1NP_001374530.1  zinc finger protein 383

    Status: REVIEWED

    Source sequence(s)
    AC012309, AC016590, KC877738
    Related
    ENSP00000507972.1, ENST00000684119.1
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:231475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:170192
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:212237
    zf-H2C2_2; Zinc-finger double domain
  13. NM_001387602.1NP_001374531.1  zinc finger protein 383

    Status: REVIEWED

    Source sequence(s)
    AC012309, AC016590, KC877738
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:231475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:170192
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:212237
    zf-H2C2_2; Zinc-finger double domain
  14. NM_152604.3NP_689817.1  zinc finger protein 383

    See identical proteins and their annotated locations for NP_689817.1

    Status: REVIEWED

    Source sequence(s)
    AC012309, AC016590, AK122892, AY438646, KC877738
    Consensus CDS
    CCDS12501.1
    UniProtKB/Swiss-Prot
    Q8NA42
    Related
    ENSP00000340132.2, ENST00000352998.7
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:231475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:170192
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:212237
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    37217243..37248740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526587.3XP_011524889.1  zinc finger protein 383 isoform X1

    See identical proteins and their annotated locations for XP_011524889.1

    UniProtKB/Swiss-Prot
    Q8NA42
    Related
    ENSP00000466101.1, ENST00000590503.5
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:231475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:170192
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:212237
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011526590.3XP_011524892.1  zinc finger protein 383 isoform X1

    See identical proteins and their annotated locations for XP_011524892.1

    UniProtKB/Swiss-Prot
    Q8NA42
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:231475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:170192
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:212237
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017026424.2XP_016881913.1  zinc finger protein 383 isoform X1

    UniProtKB/Swiss-Prot
    Q8NA42
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:231475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:170192
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:212237
    zf-H2C2_2; Zinc-finger double domain
  4. XM_011526588.3XP_011524890.1  zinc finger protein 383 isoform X1

    See identical proteins and their annotated locations for XP_011524890.1

    UniProtKB/Swiss-Prot
    Q8NA42
    Conserved Domains (5) summary
    smart00349
    Location:666
    KRAB; krueppel associated box
    COG5048
    Location:231475
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:312332
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:170192
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:212237
    zf-H2C2_2; Zinc-finger double domain
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