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ZNF579 zinc finger protein 579 [ Homo sapiens (human) ]

Gene ID: 163033, updated on 17-Jun-2024

Summary

Official Symbol
ZNF579provided by HGNC
Official Full Name
zinc finger protein 579provided by HGNC
Primary source
HGNC:HGNC:26646
See related
Ensembl:ENSG00000218891 AllianceGenome:HGNC:26646
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables RNA binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney (RPKM 3.1), stomach (RPKM 2.8) and 24 other tissues See more
Orthologs
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Genomic context

See ZNF579 in Genome Data Viewer
Location:
19q13.42
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (55576774..55580848, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (58672701..58677500, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56088140..56092214, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56042573-56043073 Neighboring gene SH3 domain binding kinase family member 2 Neighboring gene Sharpr-MPRA regulatory region 3421 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56056311-56057147 Neighboring gene Sharpr-MPRA regulatory region 14522 Neighboring gene SH3 domain binding kinase family member 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:56064283-56064783 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11043 Neighboring gene Sharpr-MPRA regulatory region 13032 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11045 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:56110254-56111128 Neighboring gene FLT3 interacting zinc finger 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:56111129-56112002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:56113981-56114531 Neighboring gene zinc finger protein 524

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat is identified to have a physical interaction with zinc finger protein 579 (ZNF579) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152600.3NP_689813.2  zinc finger protein 579

    See identical proteins and their annotated locations for NP_689813.2

    Status: VALIDATED

    Source sequence(s)
    AC008735, AK092772, AW003562, CN340494, CX781546
    Consensus CDS
    CCDS12927.1
    UniProtKB/Swiss-Prot
    Q8NAF0
    Related
    ENSP00000320188.3, ENST00000325421.7
    Conserved Domains (3) summary
    COG5048
    Location:70119
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:386406
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:5883
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    55576774..55580848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026411.3XP_016881900.1  zinc finger protein 579 isoform X3

  2. XM_017026410.3XP_016881899.1  zinc finger protein 579 isoform X2

  3. XM_017026409.3XP_016881898.1  zinc finger protein 579 isoform X1

  4. XM_047438318.1XP_047294274.1  zinc finger protein 579 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    58672701..58677500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320059.1XP_054176034.1  zinc finger protein 579 isoform X4