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ZNF846 zinc finger protein 846 [ Homo sapiens (human) ]

Gene ID: 162993, updated on 23-Nov-2021

Summary

Official Symbol
ZNF846provided by HGNC
Official Full Name
zinc finger protein 846provided by HGNC
Primary source
HGNC:HGNC:27260
See related
Ensembl:ENSG00000196605 Ensembl:ENSG00000267370
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in prostate (RPKM 2.6), brain (RPKM 2.1) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF846 in Genome Data Viewer
Location:
19p13.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (9748619..9786160, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9862669..9896836, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372270 Neighboring gene zinc finger protein 562 pseudogene Neighboring gene ubiquitin conjugating enzyme E2 L4 (pseudogene) Neighboring gene uncharacterized LOC100505555 Neighboring gene F-box and leucine rich repeat protein 12 Neighboring gene ribosomal protein L10 pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 846
Names
zinc finger protein 420 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077624.3NP_001071092.1  zinc finger protein 846 isoform 1

    See identical proteins and their annotated locations for NP_001071092.1

    Status: VALIDATED

    Source sequence(s)
    AC008752
    Consensus CDS
    CCDS42496.1
    UniProtKB/Swiss-Prot
    Q147U1
    Related
    ENSP00000380999.1, ENST00000397902.6
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:106496
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:368388
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:338360
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:845
    KRAB; KRAB box
    pfam13465
    Location:464489
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001353798.2NP_001340727.1  zinc finger protein 846 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008752
    Conserved Domains (2) summary
    COG5048
    Location:2367
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:239259
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001353799.2NP_001340728.1  zinc finger protein 846 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008752
    Conserved Domains (3) summary
    smart00349
    Location:866
    KRAB; krueppel associated box
    COG5048
    Location:105495
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:367387
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001353800.3NP_001340729.1  zinc finger protein 846 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) initiates at an upstream alternate promoter and differs at both the 5' and 3' ends compared to variant 1. The encoded isoform (4) has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (3) summary
    smart00349
    Location:866
    KRAB; krueppel associated box
    COG5189
    Location:249327
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:227247
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001395830.1NP_001382759.1  zinc finger protein 846 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (3) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5189
    Location:250328
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:228248
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001395831.1NP_001382760.1  zinc finger protein 846 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (3) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5189
    Location:250328
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:228248
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. NM_001395832.1NP_001382761.1  zinc finger protein 846 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (3) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5189
    Location:250328
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:228248
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. NM_001395833.1NP_001382762.1  zinc finger protein 846 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (2) summary
    COG5189
    Location:214292
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:192212
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. NM_001395834.1NP_001382763.1  zinc finger protein 846 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (2) summary
    COG5189
    Location:214292
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:192212
    ZF_C2H2; C2H2 Zn finger [structural motif]
  10. NM_001395835.1NP_001382764.1  zinc finger protein 846 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (3) summary
    COG5189
    Location:213291
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:191211
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cl02581
    Location:130
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  11. NM_001395836.1NP_001382765.1  zinc finger protein 846 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (2) summary
    COG5189
    Location:193271
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:171191
    ZF_C2H2; C2H2 Zn finger [structural motif]
  12. NM_001395837.1NP_001382766.1  zinc finger protein 846 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (2) summary
    COG5189
    Location:193271
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:171191
    ZF_C2H2; C2H2 Zn finger [structural motif]
  13. NM_001395838.1NP_001382767.1  zinc finger protein 846 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (2) summary
    COG5189
    Location:151229
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:129149
    ZF_C2H2; C2H2 Zn finger [structural motif]
  14. NM_001395839.1NP_001382768.1  zinc finger protein 846 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (2) summary
    COG5189
    Location:121199
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:99119
    ZF_C2H2; C2H2 Zn finger [structural motif]
  15. NM_001395840.1NP_001382769.1  zinc finger protein 846 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (2) summary
    COG5189
    Location:121199
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:99119
    ZF_C2H2; C2H2 Zn finger [structural motif]
  16. NM_001395841.1NP_001382770.1  zinc finger protein 846 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (2) summary
    COG5189
    Location:121199
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:99119
    ZF_C2H2; C2H2 Zn finger [structural motif]
  17. NM_001395842.1NP_001382771.1  zinc finger protein 846 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (2) summary
    COG5189
    Location:121199
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:99119
    ZF_C2H2; C2H2 Zn finger [structural motif]
  18. NM_001395843.1NP_001382772.1  zinc finger protein 846 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
    Conserved Domains (2) summary
    COG5189
    Location:121199
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:99119
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_172869.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
  2. NR_172870.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
  3. NR_172871.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
  4. NR_172872.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759
  5. NR_172873.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008752, AC008759

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    9748619..9786160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_024149.1: Suppressed sequence

    Description
    NG_024149.1: This RefSeq was removed because it is primarily UTR sequence.
  2. NR_148544.1: Suppressed sequence

    Description
    NR_148544.1: This RefSeq was removed because currently there is no support for the transcript.
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