Sign in to NCBI
Format

Send to:

Choose Destination

ZNF320 zinc finger protein 320 [ Homo sapiens (human) ]

Gene ID: 162967, updated on 17-Jun-2019

Summary

Go to the top of the page Help
Official Symbol
ZNF320provided by HGNC
Official Full Name
zinc finger protein 320provided by HGNC
Primary source
HGNC:HGNC:13842
See related
Ensembl:ENSG00000182986 Ensembl:ENSG00000204604 MIM:606427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFPL
Summary
ZNF320 encodes a Kruppel-like zinc finger protein. Members of this protein family are involved in activation or repression of transcription.[supplied by OMIM, Jul 2002]
Expression
Ubiquitous expression in urinary bladder (RPKM 3.5), thyroid (RPKM 3.3) and 25 other tissues See more
Orthologs
all

Genomic context

Go to the top of the page Help
See ZNF320 in Genome Data Viewer
Location:
19q13.41
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (52859491..52897727, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53379425..53394599, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein nuclear 1 pseudogene Neighboring gene zinc finger protein 28 Neighboring gene zinc finger protein 468 Neighboring gene zinc finger protein 888 Neighboring gene ZNF816-ZNF321P readthrough Neighboring gene zinc finger protein 321, pseudogene Neighboring gene zinc finger protein 816

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells. Chernova OB, et al. Oncogene, 2001 Aug 30. PMID 11536051
  2. Genome-wide association study of Alzheimer's disease with psychotic symptoms. Hollingworth P, et al. Mol Psychiatry, 2012 Dec. PMID 22005930, Free PMC Article
  3. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article
  4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Genome-wide association study of Alzheimer's disease with psychotic symptoms.
NHGRI GWA Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from BioSystems

Go to the top of the page Help
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • DKFZp686G16228

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
  
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
metal ion binding IEA
Inferred from Electronic Annotation
more info
  
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 320
Names
zinc finger gene 320
zinc finger protein like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351773.1 → NP_001338702.1  zinc finger protein 320 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein (isoform 1).
    Source sequence(s)
    AC010487, AI344388, AK096348, BC131555, DA025391, DA742339
    Consensus CDS
    CCDS33095.1
    Related
    ENSP00000375660.2, ENST00000391781.6
    Conserved Domains (4) summary
    COG5048
    Location:147 → 483
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:25 → 216
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:303 → 323
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box

  2. NM_001351774.2 → NP_001338703.1  zinc finger protein 320 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein (isoform 1).
    Source sequence(s)
    AC010487, AI344388, AK096348, BC105738, BC131555, DA742339, DA852671
    Consensus CDS
    CCDS33095.1
    Related
    ENSP00000473091.1, ENST00000595635.5
    Conserved Domains (4) summary
    COG5048
    Location:147 → 483
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:25 → 216
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:303 → 323
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box

  3. NM_001351775.2 → NP_001338704.1  zinc finger protein 320 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein (isoform 1).
    Source sequence(s)
    AC010487, AI344388, AK096348, BC105738, BC131555, DA742339, DA852671
    Consensus CDS
    CCDS33095.1
    Conserved Domains (4) summary
    COG5048
    Location:147 → 483
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:25 → 216
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:303 → 323
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box

  4. NM_001351776.2 → NP_001338705.1  zinc finger protein 320 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-5 encode the same protein (isoform 1).
    Source sequence(s)
    AC010487, AI344388, AK096348, BC131555, DA742339, DA852671
    Consensus CDS
    CCDS33095.1
    Conserved Domains (4) summary
    COG5048
    Location:147 → 483
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:25 → 216
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:303 → 323
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box

  5. NM_001351777.1 → NP_001338706.1  zinc finger protein 320 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains two alternate exons in the 3' coding region, including an alternate terminal exon, compared to variant 1. The encoded isoform (2) is significantly shorter, and contains a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC008813, AC010487, CA425481, DA025391, DA415801, DA742339, DC418794
    Conserved Domains (1) summary
    pfam01352
    Location:7 → 48
    KRAB; KRAB box

  6. NM_207333.3 → NP_997216.2  zinc finger protein 320 isoform 1

    See identical proteins and their annotated locations for NP_997216.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-5 encode the same protein (isoform 1).
    Source sequence(s)
    AC010487, AI344388, AK096348, BC131555, DA025391, DA742339
    Consensus CDS
    CCDS33095.1
    UniProtKB/Swiss-Prot
    A2RRD8
    Conserved Domains (4) summary
    COG5048
    Location:147 → 483
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:25 → 216
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:303 → 323
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    52859491..52897727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451397.1 → XP_024307165.1  zinc finger protein 320 isoform X1

    Conserved Domains (3) summary
    sd00017
    Location:155 → 175
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:168 → 191
    zf-H2C2_2; Zinc-finger double domain

  2. XM_024451396.1 → XP_024307164.1  zinc finger protein 320 isoform X1

    Conserved Domains (3) summary
    sd00017
    Location:155 → 175
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 48
    KRAB; KRAB box
    pfam13465
    Location:168 → 191
    zf-H2C2_2; Zinc-finger double domain

  3. XM_024451398.1 → XP_024307166.1  zinc finger protein 320 isoform X2

    Conserved Domains (1) summary
    pfam01352
    Location:7 → 48
    KRAB; KRAB box

  4. XM_024451399.1 → XP_024307167.1  zinc finger protein 320 isoform X3

    Conserved Domains (1) summary
    pfam01352
    Location:7 → 48
    KRAB; KRAB box

RNA

  1. XR_002958277.1 RNA Sequence

  2. XR_002958275.1 RNA Sequence

  3. XR_002958279.1 RNA Sequence

  4. XR_001753616.2 RNA Sequence

  5. XR_002958276.1 RNA Sequence

  6. XR_002958278.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_024200.2: Suppressed sequence

    Description
    NG_024200.2: This RefSeq was removed because there is now support for transcription in this region.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2RRD8.1 GenPept UniProtKB/Swiss-Prot:A2RRD8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous
You are here: NCBI > Genes & Expression > Gene
Support Center