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ZNF600 zinc finger protein 600 [ Homo sapiens (human) ]

Gene ID: 162966, updated on 10-Oct-2019

Summary

Official Symbol
ZNF600provided by HGNC
Official Full Name
zinc finger protein 600provided by HGNC
Primary source
HGNC:HGNC:30951
See related
Ensembl:ENSG00000189190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KR-ZNF1
Expression
Ubiquitous expression in small intestine (RPKM 4.5), spleen (RPKM 4.0) and 25 other tissues See more
Orthologs

Genomic context

See ZNF600 in Genome Data Viewer
Location:
19q13.41
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (52764184..52786825, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53268747..53290034, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 611 Neighboring gene uncharacterized LOC105372452 Neighboring gene uncharacterized LOC105372451 Neighboring gene poly(A) binding protein nuclear 1 pseudogene Neighboring gene zinc finger protein 28 Neighboring gene zinc finger protein 468

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
NHGRI GWA Catalog

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686F06123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 600
Names
zinc finger protein KR-ZNF1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321866.2NP_001308795.1  zinc finger protein 600 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008813, BX640933, DB158392
    UniProtKB/Swiss-Prot
    Q6ZNG1
    Conserved Domains (6) summary
    smart00349
    Location:2471
    KRAB; krueppel associated box
    COG5048
    Location:341748
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:317337
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:707729
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2460
    KRAB; KRAB box
    pfam13465
    Location:357382
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001321867.2NP_001308796.1  zinc finger protein 600 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008813, BX640933, DB158392
    UniProtKB/Swiss-Prot
    Q6ZNG1
    Related
    ENSP00000497540.1, ENST00000648973.1
    Conserved Domains (6) summary
    smart00349
    Location:2471
    KRAB; krueppel associated box
    COG5048
    Location:341748
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:317337
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:707729
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2460
    KRAB; KRAB box
    pfam13465
    Location:357382
    zf-H2C2_2; Zinc-finger double domain
  3. NM_198457.4NP_940859.3  zinc finger protein 600 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC008813, AK131231, BX640933, DB158392
    Consensus CDS
    CCDS12856.1
    UniProtKB/Swiss-Prot
    Q6ZNG1
    Related
    ENSP00000344791.2, ENST00000338230.3
    Conserved Domains (4) summary
    COG5048
    Location:272679
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:248268
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:638660
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:288313
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    52764184..52786825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026391.1XP_016881880.1  zinc finger protein 600 isoform X1

    Conserved Domains (6) summary
    smart00349
    Location:2471
    KRAB; krueppel associated box
    COG5048
    Location:341748
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:317337
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:707729
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2460
    KRAB; KRAB box
    pfam13465
    Location:357382
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017026390.1XP_016881879.1  zinc finger protein 600 isoform X1

    Conserved Domains (6) summary
    smart00349
    Location:2471
    KRAB; krueppel associated box
    COG5048
    Location:341748
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:317337
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:707729
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2460
    KRAB; KRAB box
    pfam13465
    Location:357382
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017026392.1XP_016881881.1  zinc finger protein 600 isoform X1

    Conserved Domains (6) summary
    smart00349
    Location:2471
    KRAB; krueppel associated box
    COG5048
    Location:341748
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:317337
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:707729
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2460
    KRAB; KRAB box
    pfam13465
    Location:357382
    zf-H2C2_2; Zinc-finger double domain
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