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DBN1 drebrin 1 [ Homo sapiens (human) ]

Gene ID: 1627, updated on 11-Sep-2019

Summary

Official Symbol
DBN1provided by HGNC
Official Full Name
drebrin 1provided by HGNC
Primary source
HGNC:HGNC:2695
See related
Ensembl:ENSG00000113758 MIM:126660
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D0S117E
Summary
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in endometrium (RPKM 21.1), brain (RPKM 16.5) and 24 other tissues See more
Orthologs

Genomic context

See DBN1 in Genome Data Viewer
Location:
5q35.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (177456592..177480368, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176883613..176900694, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 34 member 1 Neighboring gene coagulation factor XII Neighboring gene G protein-coupled receptor kinase 6 Neighboring gene PRR7 antisense RNA 1 Neighboring gene proline rich 7, synaptic Neighboring gene PDZ and LIM domain 7 Neighboring gene docking protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Overexpression of the N-terminal region of drebrin inhibits HIV-1 Env-induced membrane fusion. Downregulation of drebrin expression by siRNA increases HIV-1 syncytia formation and viral entry PubMed
env Drebrin interacts and co-localizes with CD4 and CXCR4 during HIV-1 infection of CD4+ T cells in an Env-dependent manner PubMed
env Accumulation of drebrin at Env-induced capping areas and Env-induced cellular contacts, but not at unspecific cell to cell contacts, illustrates the specificity of drebrin recruiment by HIV-1 Env PubMed
Pr55(Gag) gag HIV-1 Gag co-localizes with drebrin in HIV-1-infected CD4+ T cells PubMed
Tat tat Drebrin 1 (DBN1) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
tat Expression of HIV-1 Tat downregulates the abundance of drebrin 1 (DBN1) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434D064

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding NAS
Non-traceable Author Statement
more info
PubMed 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cadherin binding HDA PubMed 
profilin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament organization ISS
Inferred from Sequence or Structural Similarity
more info
 
cell communication by chemical coupling IEA
Inferred from Electronic Annotation
more info
 
cell communication by electrical coupling IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic sequestering of protein IDA
Inferred from Direct Assay
more info
PubMed 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
maintenance of protein location in cell IEA
Inferred from Electronic Annotation
more info
 
neural precursor cell proliferation IEA
Inferred from Electronic Annotation
more info
 
neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of axon extension IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of dendritic spine morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of receptor localization to synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of dendrite development NAS
Non-traceable Author Statement
more info
PubMed 
regulation of neuronal synaptic plasticity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actomyosin NAS
Non-traceable Author Statement
more info
PubMed 
cortical actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cortical cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendrite NAS
Non-traceable Author Statement
more info
PubMed 
gap junction IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic cytosol IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
site of polarized growth IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
drebrin
Names
developmentally-regulated brain protein
drebrin A
drebrin E
drebrin E2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363541.1NP_001350470.1  drebrin isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini and is longer compared to isoform a.
    Source sequence(s)
    AC145098, LC369599
    Consensus CDS
    CCDS87354.1
    Related
    ENSP00000377195.1, ENST00000393565.5
    Conserved Domains (2) summary
    cd11281
    Location:4139
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    cl26464
    Location:376609
    Atrophin-1; Atrophin-1 family
  2. NM_001364151.1NP_001351080.1  drebrin isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction and contains an alternate in-frame exon compared to variant 1. The resulting isoform (d) has the same N- and C-termini and is longer compared to isoform a. Variant 4 encodes the longest isoform (d).
    Source sequence(s)
    AC145098, AK295295
    Conserved Domains (2) summary
    cd11281
    Location:4138
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    cl26464
    Location:375608
    Atrophin-1; Atrophin-1 family
  3. NM_001364152.1NP_001351081.1  drebrin isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (e) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC145098, AK295295
  4. NM_004395.3NP_004386.2  drebrin isoform a

    See identical proteins and their annotated locations for NP_004386.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (a).
    Source sequence(s)
    AC145098, BC000283, BC114553, DA245346, DR158741
    Consensus CDS
    CCDS4420.1
    UniProtKB/Swiss-Prot
    Q16643
    Related
    ENSP00000308532.5, ENST00000309007.9
    Conserved Domains (1) summary
    cd11281
    Location:4139
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
  5. NM_080881.2NP_543157.1  drebrin isoform b

    See identical proteins and their annotated locations for NP_543157.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes isoform b and has a different 5' UTR and 5' coding sequence as compared to transcript variant 1. The first 31 amino acids of this isoform differ from the first 29 amino acids of isoform a.
    Source sequence(s)
    AC145098, AL110225, BC000283, BC114553
    Consensus CDS
    CCDS4421.1
    UniProtKB/Swiss-Prot
    Q16643
    Related
    ENSP00000292385.5, ENST00000292385.9
    Conserved Domains (1) summary
    cd11281
    Location:32141
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    177456592..177480368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534447.2XP_011532749.1  drebrin isoform X3

    Conserved Domains (1) summary
    cd11281
    Location:6128
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
  2. XM_011534446.2XP_011532748.1  drebrin isoform X1

    Conserved Domains (1) summary
    cd11281
    Location:32141
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
  3. XM_006714826.2XP_006714889.1  drebrin isoform X5

    Conserved Domains (1) summary
    cl15697
    Location:176
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  4. XM_017009139.1XP_016864628.1  drebrin isoform X1

    Conserved Domains (1) summary
    cd11281
    Location:32141
    ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
  5. XM_017009140.1XP_016864629.1  drebrin isoform X4

    UniProtKB/Swiss-Prot
    Q16643
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