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KRT28 keratin 28 [ Homo sapiens (human) ]

Gene ID: 162605, updated on 26-Nov-2021

Summary

Official Symbol
KRT28provided by HGNC
Official Full Name
keratin 28provided by HGNC
Primary source
HGNC:HGNC:30842
See related
Ensembl:ENSG00000173908 MIM:616677
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KRT25D; K25IRS4
Summary
This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See KRT28 in Genome Data Viewer
Location:
17q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (40792196..40799959, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38948448..38956211, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 26 Neighboring gene keratin 27 Neighboring gene uncharacterized LOC105371776 Neighboring gene KRT10 antisense RNA 1 Neighboring gene keratin 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin, type I cytoskeletal 28
Names
CK-28
K25D
K28
cytokeratin-28
keratin 28, type I
keratin-25D
type I inner root sheath specific keratin 25 irs4
type I inner root sheath-specific keratin-K25irs4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012419.1 RefSeqGene

    Range
    5001..12764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_181535.3NP_853513.2  keratin, type I cytoskeletal 28

    See identical proteins and their annotated locations for NP_853513.2

    Status: REVIEWED

    Source sequence(s)
    AC090283, AK129827
    Consensus CDS
    CCDS11376.1
    UniProtKB/Swiss-Prot
    Q7Z3Y7
    Related
    ENSP00000305263.7, ENST00000306658.8
    Conserved Domains (1) summary
    pfam00038
    Location:85396
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    40792196..40799959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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