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PHOSPHO1 phosphoethanolamine/phosphocholine phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 162466, updated on 24-Nov-2020

Summary

Official Symbol
PHOSPHO1provided by HGNC
Official Full Name
phosphoethanolamine/phosphocholine phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:16815
See related
Ensembl:ENSG00000173868
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 17.3), bone marrow (RPKM 8.3) and 3 other tissues See more
Orthologs

Genomic context

See PHOSPHO1 in Genome Data Viewer
Location:
17q21.32
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (49223366..49230787, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47300728..47309009, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene G protein subunit gamma transducin 2 Neighboring gene ABI family member 3 Neighboring gene uncharacterized LOC105371816 Neighboring gene uncharacterized FLJ40194 Neighboring gene microRNA 6129

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphocholine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
phosphoethanolamine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
pyrophosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
bone mineralization involved in bone maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
endochondral ossification IEA
Inferred from Electronic Annotation
more info
 
phosphatidylcholine biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylethanolamine biosynthetic process TAS
Traceable Author Statement
more info
 
regulation of bone mineralization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
extracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphoethanolamine/phosphocholine phosphatase
Names
phosphatase, orphan 1
NP_001137276.1
NP_848595.1
XP_016879760.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143804.2NP_001137276.1  phosphoethanolamine/phosphocholine phosphatase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC004797, AJ457189, BC029931
    Consensus CDS
    CCDS45726.1
    UniProtKB/Swiss-Prot
    Q8TCT1
    Related
    ENSP00000406909.1, ENST00000413580.5
    Conserved Domains (2) summary
    pfam00702
    Location:53241
    Hydrolase; haloacid dehalogenase-like hydrolase
    pfam06888
    Location:52289
    Put_Phosphatase; Putative Phosphatase
  2. NM_178500.4NP_848595.1  phosphoethanolamine/phosphocholine phosphatase isoform 2

    See identical proteins and their annotated locations for NP_848595.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site, compared to variant 1, that results in the use of an upstream start codon. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.
    Source sequence(s)
    AC004797, AJ457189
    Consensus CDS
    CCDS11547.1
    UniProtKB/Swiss-Prot
    Q8TCT1
    Related
    ENSP00000311925.4, ENST00000310544.8
    Conserved Domains (1) summary
    pfam06888
    Location:27264
    Put_Phosphatase; Putative Phosphatase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    49223366..49230787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024271.1XP_016879760.1  phosphoethanolamine/phosphocholine phosphatase isoform X1

    Conserved Domains (2) summary
    pfam00702
    Location:111299
    Hydrolase; haloacid dehalogenase-like hydrolase
    pfam06888
    Location:110347
    Put_Phosphatase; Putative Phosphatase
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