Format

Send to:

Choose Destination

MARCHF10 membrane associated ring-CH-type finger 10 [ Homo sapiens (human) ]

Gene ID: 162333, updated on 22-Aug-2020

Summary

Official Symbol
MARCHF10provided by HGNC
Official Full Name
membrane associated ring-CH-type finger 10provided by HGNC
Primary source
HGNC:HGNC:26655
See related
Ensembl:ENSG00000173838 MIM:613337
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF190; MARCH-X; MARCH10
Summary
MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]
Expression
Restricted expression toward testis (RPKM 20.7) See more
Orthologs

Genomic context

See MARCHF10 in Genome Data Viewer
Location:
17q23.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (62701314..62808346, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (60778675..60885705, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268202 Neighboring gene uncharacterized LOC107985020 Neighboring gene mannose receptor C type 2 Neighboring gene RNA, U6 small nuclear 446, pseudogene Neighboring gene uncharacterized LOC105371855 Neighboring gene MARCHF10 divergent transcript Neighboring gene PRELI domain containing 3B pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35757

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable E3 ubiquitin-protein ligase MARCHF10
Names
RING-type E3 ubiquitin transferase MARCH10
RING-type E3 ubiquitin transferase MARCHF10
membrane associated ring finger 10
membrane-associated RING finger protein 10
membrane-associated RING-CH protein X
membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
probable E3 ubiquitin-protein ligase MARCH10
ring finger protein 190
testis secretory sperm-binding protein Li 228n
NP_001094345.1
NP_001275708.1
NP_001275709.1
NP_689811.2
XP_005257152.2
XP_005257153.2
XP_005257154.2
XP_005257155.2
XP_005257157.2
XP_005257159.2
XP_005257160.1
XP_005257163.2
XP_011522737.1
XP_011522738.1
XP_011522739.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100875.3NP_001094345.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform 1

    See identical proteins and their annotated locations for NP_001094345.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 3. Variants 1 and 2 encode the same isoform (1), which is shorter than isoform 2.
    Source sequence(s)
    AK093076, AK122947, AW473122, BC035021
    Consensus CDS
    CCDS11635.1
    UniProtKB/Swiss-Prot
    Q8NA82
    UniProtKB/TrEMBL
    A0A140VKA1, B3KVK0
    Related
    ENSP00000416177.2, ENST00000456609.6
    Conserved Domains (1) summary
    smart00744
    Location:659715
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  2. NM_001288779.2NP_001275708.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform 2

    See identical proteins and their annotated locations for NP_001275708.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (2).
    Source sequence(s)
    AW138484, AW473122, BC035021, BX648705
    Consensus CDS
    CCDS74123.1
    UniProtKB/Swiss-Prot
    Q8NA82
    UniProtKB/TrEMBL
    J3KTN9
    Related
    ENSP00000463080.1, ENST00000583600.5
    Conserved Domains (1) summary
    smart00744
    Location:697753
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  3. NM_001288780.2NP_001275709.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform 3

    See identical proteins and their annotated locations for NP_001275709.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and contains multiple coding region differences, compared to variant 3. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AI223162, AI262871, AK122947, AW263642, BC035021, BX105355, HY010920
    Consensus CDS
    CCDS74122.1
    UniProtKB/Swiss-Prot
    Q8NA82
    UniProtKB/TrEMBL
    B3KVK0, G3V1Q5
    Related
    ENSP00000443746.2, ENST00000544856.6
    Conserved Domains (1) summary
    smart00744
    Location:658714
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  4. NM_152598.4NP_689811.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform 1

    See identical proteins and their annotated locations for NP_689811.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 5' coding region, compared to variant 3. Variants 1 and 2 encode the same isoform (1), which is shorter than isoform 2.
    Source sequence(s)
    AK093076, AK122947, AW473122, BC035021
    Consensus CDS
    CCDS11635.1
    UniProtKB/Swiss-Prot
    Q8NA82
    UniProtKB/TrEMBL
    A0A140VKA1, B3KVK0
    Related
    ENSP00000311496.5, ENST00000311269.10
    Conserved Domains (1) summary
    smart00744
    Location:659715
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    62701314..62808346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257102.3XP_005257159.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X5

    Conserved Domains (1) summary
    smart00744
    Location:658714
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  2. XM_005257100.3XP_005257157.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X4

    See identical proteins and their annotated locations for XP_005257157.2

    Conserved Domains (1) summary
    smart00744
    Location:659715
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  3. XM_005257098.3XP_005257155.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X2

    Conserved Domains (1) summary
    smart00744
    Location:696752
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  4. XM_011524435.2XP_011522737.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X3

    Conserved Domains (1) summary
    smart00744
    Location:696752
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  5. XM_005257095.3XP_005257152.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X1

    See identical proteins and their annotated locations for XP_005257152.2

    Conserved Domains (1) summary
    smart00744
    Location:697753
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  6. XM_011524436.1XP_011522738.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X4

    See identical proteins and their annotated locations for XP_011522738.1

    Conserved Domains (1) summary
    smart00744
    Location:659715
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  7. XM_005257096.2XP_005257153.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X1

    See identical proteins and their annotated locations for XP_005257153.2

    Conserved Domains (1) summary
    smart00744
    Location:697753
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  8. XM_005257097.3XP_005257154.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X1

    See identical proteins and their annotated locations for XP_005257154.2

    Conserved Domains (1) summary
    smart00744
    Location:697753
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  9. XM_005257106.4XP_005257163.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X8

    Related
    ENSP00000464220.1, ENST00000580520.5
    Conserved Domains (1) summary
    smart00744
    Location:586642
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  10. XM_011524437.2XP_011522739.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X6

    Conserved Domains (1) summary
    smart00744
    Location:658714
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
  11. XM_005257103.2XP_005257160.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X7

    See identical proteins and their annotated locations for XP_005257160.1

    UniProtKB/TrEMBL
    G3V1Q5
    Conserved Domains (1) summary
    smart00744
    Location:658714
    RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

RNA

  1. XR_934406.3 RNA Sequence

Support Center