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ZFP1 ZFP1 zinc finger protein [ Homo sapiens (human) ]

Gene ID: 162239, updated on 21-Dec-2019

Summary

Official Symbol
ZFP1provided by HGNC
Official Full Name
ZFP1 zinc finger proteinprovided by HGNC
Primary source
HGNC:HGNC:23328
See related
Ensembl:ENSG00000184517 MIM:617230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF475
Summary
This gene belongs to the zinc finger protein family. Some members of this family bind to DNA by zinc-mediated secondary structures called zinc fingers, and are involved in transcriptional regulation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in brain (RPKM 6.0), thyroid (RPKM 4.0) and 24 other tissues See more
Orthologs

Genomic context

See ZFP1 in Genome Data Viewer
Location:
16q23.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (75126285..75172234)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (75182392..75206132)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene zinc and ring finger 1 Neighboring gene lactate dehydrogenase D Neighboring gene RPS4Y1 pseudogene 1 Neighboring gene chymotrypsinogen B2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34243

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 1 homolog
Names
zinc finger protein 475

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318469.2NP_001305398.1  zinc finger protein 1 homolog isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK091562, BC033774, BC064604, BP219674, DC388176
    Consensus CDS
    CCDS10914.2
    UniProtKB/Swiss-Prot
    Q6P2D0
    Related
    ENSP00000377080.2, ENST00000393430.6
    Conserved Domains (3) summary
    COG5048
    Location:146403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:326346
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:747
    KRAB; KRAB box
  2. NM_001318471.2NP_001305400.1  zinc finger protein 1 homolog isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK091562, BC033774, BC064604, BP219674, DC402593
    Consensus CDS
    CCDS82013.1
    UniProtKB/Swiss-Prot
    Q6P2D0
    UniProtKB/TrEMBL
    J3KNQ1
    Conserved Domains (2) summary
    COG5048
    Location:113370
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:293313
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001318472.2NP_001305401.1  zinc finger protein 1 homolog isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK091562, AK308134, BC033774, BC064604, BP219674, DC388176
    Consensus CDS
    CCDS82013.1
    UniProtKB/Swiss-Prot
    Q6P2D0
    UniProtKB/TrEMBL
    J3KNQ1
    Related
    ENSP00000333192.4, ENST00000332307.4
    Conserved Domains (2) summary
    COG5048
    Location:113370
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:293313
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001318473.2NP_001305402.1  zinc finger protein 1 homolog isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 5 and 6 encode the same isoform (3), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK091562, BC033774, BC064604, BP219674, DA781502, DC388176
    UniProtKB/Swiss-Prot
    Q6P2D0
    Conserved Domains (4) summary
    COG5048
    Location:91348
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:271291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:269291
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:171196
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001318474.2NP_001305403.1  zinc finger protein 1 homolog isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 5 and 6 encode the same isoform (3), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK091562, BC033774, BC064604, BP219674, DC371394
    UniProtKB/Swiss-Prot
    Q6P2D0
    Conserved Domains (4) summary
    COG5048
    Location:91348
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:271291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:269291
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:171196
    zf-H2C2_2; Zinc-finger double domain
  6. NM_001318475.1NP_001305404.1  zinc finger protein 1 homolog isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate splice site in the coding region, resulting in a frameshift and an early stop codon, compared to variant 1. Variants 7 and 8 encode the same isoform (4), which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK091562, AK094761, BC033774, BC064604, BP219674, BX647144, DB075594
    Consensus CDS
    CCDS82012.1
    UniProtKB/Swiss-Prot
    Q6P2D0
    UniProtKB/TrEMBL
    H3BV40
    Related
    ENSP00000455627.1, ENST00000567481.1
    Conserved Domains (1) summary
    pfam01352
    Location:748
    KRAB; KRAB box
  7. NM_001318476.2NP_001305405.1  zinc finger protein 1 homolog isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site in the coding region, resulting in a frameshift and an early stop codon, compared to variant 1. Variants 7 and 8 encode the same isoform (4), which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK091562, AK094761, BC033774, BC064604, BP219674, BX647144, DC388176
    Consensus CDS
    CCDS82012.1
    UniProtKB/Swiss-Prot
    Q6P2D0
    UniProtKB/TrEMBL
    H3BV40
    Related
    ENSP00000457941.1, ENST00000464850.5
    Conserved Domains (1) summary
    pfam01352
    Location:748
    KRAB; KRAB box
  8. NM_153688.4NP_710155.2  zinc finger protein 1 homolog isoform 1

    See identical proteins and their annotated locations for NP_710155.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK091562, AK296560, BC033774, BC064604, BP219674, DC388176
    Consensus CDS
    CCDS10914.2
    UniProtKB/Swiss-Prot
    Q6P2D0
    Related
    ENSP00000457044.1, ENST00000570010.6
    Conserved Domains (3) summary
    COG5048
    Location:146403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:326346
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:747
    KRAB; KRAB box

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    75126285..75172234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522921.2XP_011521223.1  zinc finger protein 1 homolog isoform X2

    Conserved Domains (6) summary
    smart00349
    Location:3474
    KRAB; krueppel associated box
    COG5048
    Location:172429
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:352372
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:350372
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:3473
    KRAB; KRAB box
    pfam13465
    Location:252277
    zf-H2C2_2; Zinc-finger double domain
  2. XM_024450168.1XP_024305936.1  zinc finger protein 1 homolog isoform X4

    Conserved Domains (1) summary
    pfam01352
    Location:748
    KRAB; KRAB box
  3. XM_017022986.1XP_016878475.1  zinc finger protein 1 homolog isoform X3

    UniProtKB/TrEMBL
    J3KNQ1
    Conserved Domains (2) summary
    COG5048
    Location:113370
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:293313
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_017022984.1XP_016878473.1  zinc finger protein 1 homolog isoform X3

    UniProtKB/Swiss-Prot
    Q6P2D0
    Conserved Domains (3) summary
    COG5048
    Location:146403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:326346
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:747
    KRAB; KRAB box
  5. XM_017022983.1XP_016878472.1  zinc finger protein 1 homolog isoform X1

  6. XM_017022985.1XP_016878474.1  zinc finger protein 1 homolog isoform X3

    UniProtKB/Swiss-Prot
    Q6P2D0
    Conserved Domains (3) summary
    COG5048
    Location:146403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:326346
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:747
    KRAB; KRAB box
  7. XM_017022987.1XP_016878476.1  zinc finger protein 1 homolog isoform X3

    UniProtKB/Swiss-Prot
    Q6P2D0
    Conserved Domains (4) summary
    COG5048
    Location:91348
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:271291
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:269291
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:171196
    zf-H2C2_2; Zinc-finger double domain

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654723.1 Reference GRCh38.p13 PATCHES

    Range
    1..2424
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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