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Kpnb1 karyopherin (importin) beta 1 [ Mus musculus (house mouse) ]

Gene ID: 16211, updated on 5-Feb-2023

Summary

Official Symbol
Kpnb1provided by MGI
Official Full Name
karyopherin (importin) beta 1provided by MGI
Primary source
MGI:MGI:107532
See related
Ensembl:ENSMUSG00000001440 AllianceGenome:MGI:107532
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IPOB; Impnb
Summary
Enables Hsp90 protein binding activity; importin-alpha family protein binding activity; and nuclear import signal receptor activity. Acts upstream of or within ribosomal protein import into nucleus. Located in cytoplasmic stress granule. Part of protein-containing complex. Is expressed in brain; gonad; liver; neural retina; and pancreas. Orthologous to human KPNB1 (karyopherin subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 73.8), placenta adult (RPKM 41.1) and 26 other tissues See more
Orthologs
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Genomic context

See Kpnb1 in Genome Data Viewer
Location:
11; 11 D
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97050536..97078718, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97159710..97187892, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene T-box 21 Neighboring gene TBK1 binding protein 1 Neighboring gene microRNA 7235 Neighboring gene aminopeptidase puromycin sensitive Neighboring gene predicted gene 11592

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8315

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp90 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables importin-alpha family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear import signal receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in Ran protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in astral microtubule organization ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of mitotic spindle localization ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic chromosome movement towards spindle pole ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic metaphase plate congression ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein import into nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ribosomal protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ribosomal protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of NLS-dependent protein nuclear import complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol NAS
Non-traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum tubular network ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
importin subunit beta-1
Names
PTAC97
SCG
importin beta
karyopherin subunit beta-1
nuclear factor p97
pore targeting complex 97 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008379.3NP_032405.3  importin subunit beta-1

    See identical proteins and their annotated locations for NP_032405.3

    Status: VALIDATED

    Source sequence(s)
    AK147175, AL627445, BC052438
    Consensus CDS
    CCDS25316.1
    UniProtKB/Swiss-Prot
    P70168, Q6GTI5
    UniProtKB/TrEMBL
    A0A8C6HHT3, Q3UHW8
    Related
    ENSMUSP00000001479.4, ENSMUST00000001479.5
    Conserved Domains (2) summary
    COG5215
    Location:2871
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    sd00044
    Location:323354
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    97050536..97078718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)