Format

Send to:

Choose Destination

Kpnb1 karyopherin (importin) beta 1 [ Mus musculus (house mouse) ]

Gene ID: 16211, updated on 17-Oct-2018

Summary

Official Symbol
Kpnb1provided by MGI
Official Full Name
karyopherin (importin) beta 1provided by MGI
Primary source
MGI:MGI:107532
See related
Ensembl:ENSMUSG00000001440 Vega:OTTMUSG00000002303
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IPOB; Impnb; AA409963
Expression
Ubiquitous expression in CNS E11.5 (RPKM 73.8), placenta adult (RPKM 41.1) and 26 other tissues See more
Orthologs

Genomic context

See Kpnb1 in Genome Data Viewer
Location:
11; 11 D
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (97159710..97187892, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (97021024..97049206, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene T-box 21 Neighboring gene TBK1 binding protein 1 Neighboring gene microRNA 7235 Neighboring gene aminopeptidase puromycin sensitive Neighboring gene predicted gene 11592

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8315

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Hsp90 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
Ran GTPase binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
kinesin binding ISO
Inferred from Sequence Orthology
more info
 
nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Ran protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
astral microtubule organization ISO
Inferred from Sequence Orthology
more info
 
establishment of mitotic spindle localization ISO
Inferred from Sequence Orthology
more info
 
establishment of protein localization ISO
Inferred from Sequence Orthology
more info
 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
mitotic chromosome movement towards spindle pole ISO
Inferred from Sequence Orthology
more info
 
mitotic metaphase plate congression ISO
Inferred from Sequence Orthology
more info
 
mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein import into nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
ribosomal protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosomal protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ribosomal protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum tubular network ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
importin subunit beta-1
Names
PTAC97
SCG
importin beta
karyopherin subunit beta-1
nuclear factor p97
pore targeting complex 97 kDa subunit

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008379.3NP_032405.3  importin subunit beta-1

    See identical proteins and their annotated locations for NP_032405.3

    Status: VALIDATED

    Source sequence(s)
    AK147175, AL627445, BC052438
    Consensus CDS
    CCDS25316.1
    UniProtKB/Swiss-Prot
    P70168
    UniProtKB/TrEMBL
    Q3UHW8
    Related
    ENSMUSP00000001479.3, OTTMUSP00000002199, ENSMUST00000001479.4, OTTMUST00000004585
    Conserved Domains (4) summary
    COG5215
    Location:2871
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    cd00020
    Location:365479
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam03810
    Location:21101
    IBN_N; Importin-beta N-terminal domain
    sd00044
    Location:323354
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    97159710..97187892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center